Engineering pancreatic islets

Soria, Bernat; Andreu, Etelvina; Berná, Genoveva; Fuentes, Esther; Gil, Amparo; León–Quinto, Trinidad; Martı́n, Franz; Montanya, Eduard; Nadal, Ángel; Reig, Juan A.; Ripoll, Cristina; Roche, Enrique; Sánchez-Andrés, Juan Vicente; Segura, Javier

doi:10.1007/s004240051016

Cited by 23 publications

(40 citation statements)

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“…A third approach to overcome the limited donor tissue supply is to make use of gene therapy for engineering pancreatic islets [116][117][118][119][120][121][122]. The principal advantage of this approach is that autologous tissue and cells can be used and the problems with graft rejection and disease recurrence would probably no longer exist.…”

Section: Tolerance Inductionmentioning

confidence: 99%

Islet cell transplantation today

Bretzel

Jahr

Eckhard

et al. 2007

Langenbecks Arch Surg

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Section: Tolerance Inductionmentioning

confidence: 99%

Islet cell transplantation today

Bretzel

Jahr

Eckhard

et al. 2007

Langenbecks Arch Surg

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“…Glucose homeostasis is mainly regulated by the secretory response of the islet of Langerhans (7)(8)(9). The integral function of this endocrine unit depends on the interaction and secretion of different cell types, mainly ␣-and ␤-cells (7)(8)(9)(10). When extracellular glucose concentrations become low, ␣-cells release the hyperglycemic hormone glucagon, whereas in the presence of high concentrations of sugar, ␤-cells secrete insulin to restore normal glucose levels (7,(11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

Glucose Induces Opposite Intracellular Ca2+ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans

et al. 2006

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Homeostasis of blood glucose is mainly regulated by the coordinated secretion of glucagon and insulin from ␣-and ␤-cells within the islets of Langerhans. ] i signals in ␣-cells. These Ca 2؉ signals were synchronic among ␤-cells grouped in clusters within the islet, although they were not coordinated among the whole ␤-cell population. The response of ␣-cells was totally asynchronic. Therefore, both the ␣-and ␤-cell populations within human islets did not work as a syncitium in response to glucose. A deeper knowledge of ␣-and ␤-cell behavior within intact human islets is important to better understand the physiology of the human endocrine pancreas and may be useful to select high-quality islets for transplantation.

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“…Another aim is to construct insulin pumps that follow the dynamics of the natural pancreas more closely, for example, with respect to derivative control and pulsatile secretion. For such an ''artificial pancreas'', it would be important to include paracrine interactions between a-, b-and d-cells in the models (Soria et al 2000). Modeling of b-cells will likely move closer to clinical applications, where it can be expected to play an important role, as it continues to do in the understanding of the complex oscillatory phenomena observed in b-cells and islets.…”

Section: Modeling Of Insulin Secretionmentioning

confidence: 97%

Modeling Mechanisms of Cell Secretion

et al. 2010

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Secretion is a fundamental cellular process involving the regulated release of intracellular products from cells. Physiological functions such as neurotransmission, or the release of hormones and digestive enzymes, are all governed by cell secretion. Anomalies in the processes involved in secretion contribute to the development and progression of diseases such as diabetes and other hormonal disorders. To unravel the mechanisms that govern such diseases, it is essential to understand how hormones, growth factors and neurotransmitters are synthesized and processed, and how their signals are recognized, amplified and transmitted by intracellular signaling pathways in the target cells. Here, we discuss diverse aspects of the detailed mechanisms involved in secretion based on mathematical models. The models range from stochastic ones describing the trafficking of secretory vesicles to deterministic ones investigating the regulation of cellular processes that underlie hormonal secretion. In all cases, the models are closely related to experimental results and suggest theoretical predictions for the secretion mechanisms.

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Engineering pancreatic islets

Cited by 23 publications

References 0 publications

Islet cell transplantation today

Islet cell transplantation today

Glucose Induces Opposite Intracellular Ca2+ Concentration Oscillatory Patterns in Identified α- and β-Cells Within Intact Human Islets of Langerhans

Modeling Mechanisms of Cell Secretion

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