Engineering polymeric Janus particles for drug delivery using microfluidic solvent dissolution approach

Sundararajan, Pavithra; Wang, Jianbin; Rosen, Lawrence; Procopio, Adam; Rosenberg, Kenneth J.

doi:10.1016/j.ces.2017.12.013

Cited by 44 publications

(12 citation statements)

References 33 publications

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“…Compound sessile drops have gained considerable attention due to their potential uses in pharmaceutical formulations (Zarzar et al 2015), drug delivery (Sundararajan et al 2017) and inkjet printing (Keller et al 2018). Here, the compound sessile drops refer to the drops comprised of two or more immiscible fluids and sticking to a plate substrate.…”

Section: Introductionmentioning

confidence: 99%

On the compound sessile drops: configuration boundaries and transitions

Zhang

Gao

et al. 2021

J. Fluid Mech.

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Section: Introductionmentioning

confidence: 99%

On the compound sessile drops: configuration boundaries and transitions

Zhang

Gao

et al. 2021

J. Fluid Mech.

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“…PS‐ and PLA‐containing copolymers are emerging biomaterials due to their excellent biocompatibility and/or biodegradability . In this study, the proof of concept of using the newly developed Janus star‐like copolymer (PLLA) 8 ‐ b‐ (PS) 8 as therapeutic nanocarriers is also demonstrated.…”

Section: Methodsmentioning

confidence: 94%

Precise Synthesis of PS‐PLA Janus Star‐Like Copolymer

Fan

Win

et al. 2018

Macromol. Rapid Commun.

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In this work, an efficient strategy is designed for the precise synthesis of novel Janus star-like copolymer (polystyrene) -b-(poly(l-lactide)) , (PLLA) -b-(PS) , consisting of two types of chemically distinct polymer arms, PS and PLLA, in an asymmetric structure. During the synthesis, PLLA hemisphere carrying protected hydroxyl groups at the focal point was first synthesized via a combined reactions of esterification, light-induced "Click" chemistry, and ring opening polymerization (ROP) using a specially designed dendron as initiator. After removing the protecting moiety, the terminal hydroxyl groups on the dendron segment is increased fourfold and further modified into bromopropionate-based macroinitiator through a two-step end group transformation reaction, followed by atom transfer radical polymerization (ATRP) of styrene to obtain the desired (PLLA) -b-(PS) Janus star-like copolymer. The versatility and efficiency of the designed synthetic strategy are demonstrated by the well-defined molecular characteristics and high yields of the targeted product. In addition to the controlled degradation behavior of the PLLA segments, the remaining bromide groups located at the distal end of PS arms could allow for further fabrication of diverse building blocks through consecutive ATRP of various monomers. This work signifies the first time for facile and precise synthesis of Janus star-like copolymer with unique biphasic structure and function control.

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“…Subsequent post polymerization in the off‐chip procedures generates polymeric particles with monodisperse distribution and anisotropic shapes. Up to now, many Janus particles with different compositions and architectures have been produced via the microfluidic method . This technique possesses the advantage that the phase ratio in the Janus particles can be conveniently adjusted across a wide range by varying the flow rate of the two phases .…”

Section: Synthetic Strategies Of Polymeric Janus Nanoparticlesmentioning

confidence: 99%

Polymeric Janus Nanoparticles: Recent Advances in Synthetic Strategies, Materials Properties, and Applications

Fan

Yang

Loh

et al. 2018

Macromol. Rapid Commun.

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Polymeric Janus nanoparticles with two sides of incompatible chemistry have received increasing attention due to their tunable asymmetric structure and unique material characteristics. Recently, with the rapid progress in controlled polymerization combined with novel fabrication techniques, a large array of functional polymeric Janus particles are diversified with sophisticated architecture and applications. In this review, the most recently developed strategies for controlled synthesis of polymeric Janus nanoparticles with well-defined size and complex superstructures are summarized. In addition, the pros and cons of each approach in mediating the anisotropic shapes of polymeric Janus particles as well as their asymmetric spatial distribution of chemical compositions and functionalities are discussed and compared. Finally, these newly developed structural nanoparticles with specific shapes and surface functions orientated applications in different domains are also discussed, followed by the perspectives and challenges faced in the further advancement of polymeric Janus nanoparticles as high performance materials.

show abstract

Engineering polymeric Janus particles for drug delivery using microfluidic solvent dissolution approach

Cited by 44 publications

References 33 publications

On the compound sessile drops: configuration boundaries and transitions

On the compound sessile drops: configuration boundaries and transitions

Precise Synthesis of PS‐PLA Janus Star‐Like Copolymer

Polymeric Janus Nanoparticles: Recent Advances in Synthetic Strategies, Materials Properties, and Applications

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