Engineering repeat proteins of the immune system

McCord, Jennifer P.; Grove, Tijana Ž.

doi:10.1002/bip.23348

Cited by 2 publications

(1 citation statement)

References 106 publications

(150 reference statements)

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“…Based on these surviving repeats, we identify malleable regions of immune genes. The availability of highthroughput genome editing technologies provides a new avenue to synthesize genes with protein repeats of various lengths and compositions 95,96 . Such synthetic biology approaches will be able to provide a comprehensive picture or tness landscape of which regions of what genes can tolerate repeats and how such repeats affect their functions.…”

Section: Discussionmentioning

confidence: 99%

Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

2022

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Functional diversi cation, a higher evolutionary rate, and intense positive selection help a limited number of immune genes interact with many continuously evolving pathogens. Repeats in protein-coding regions are a well-known source of rapid functional diversi cation, adaptive variation, and evolutionary novelty.Repeats play a crucial role in biochemical functions like functional diversi cation of transcription regulation, protein kinases, cell adhesion, signaling pathways, morphogenesis, DNA repair, recombination, and RNA processing. Repeat length variation can change the associated protein's interaction, e cacy, and overall protein network. Repeats have an intrinsic unstable nature and can potentially evolve rapidly and expedite the acquisition of complex phenotypic traits and functions. Because of their ability to generate rapid, adaptive variations over short evolutionary distances, repeats are considered "tuning knobs." Repeat length variation in speci c genes, like RUNX2 and ALX4, is associated with morphological and physiological changes across vertebrates. Here we study repeat length variation as a potent source of species-speci c immune diversi cation across several clades of tetrapods. Moreover, we provide a clade-wise comprehensive list of immune genes with repeat types for future studies of morphological/evolutionary changes within species groups. We observe signi cant repeat length variation of FASLG in Rodentia and C1QC in Primates' contrasting species groups.

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Section: Discussionmentioning

confidence: 99%

Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

2022

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Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

Vijay¹,

Teekas²,

Sharma

2022

Preprint

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Functional diversification, a higher evolutionary rate, and intense positive selection help a limited number of immune genes interact with many continuously evolving pathogens. Repeats in protein-coding regions are a well-known source of rapid functional diversification, adaptive variation, and evolutionary novelty. Repeats play a crucial role in biochemical functions like functional diversification of transcription regulation, protein kinases, cell adhesion, signaling pathways, morphogenesis, DNA repair, recombination, and RNA processing. Repeat length variation can change the associated protein's interaction, efficacy, and overall protein network. Repeats have an intrinsic unstable nature and can potentially evolve rapidly and expedite the acquisition of complex phenotypic traits and functions. Because of their ability to generate rapid, adaptive variations over short evolutionary distances, repeats are considered "tuning knobs." Repeat length variation in specific genes, like RUNX2 and ALX4, is associated with morphological and physiological changes across vertebrates. Here we study repeat length variation as a potent source of species-specific immune diversification across several clades of tetrapods. Moreover, we provide a clade-wise comprehensive list of immune genes with repeat types for future studies of morphological/evolutionary changes within species groups. We observe significant repeat length variation of FASLG in Rodentia and C1QC in Primates' contrasting species groups.

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Engineering repeat proteins of the immune system

Cited by 2 publications

References 106 publications

Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

Lineage-specific protein repeat expansions and contractions reveal malleable regions of immune genes

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