2013
DOI: 10.1371/journal.pone.0075459
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Engineering Salidroside Biosynthetic Pathway in Hairy Root Cultures of Rhodiola crenulata Based on Metabolic Characterization of Tyrosine Decarboxylase

Abstract: Tyrosine decarboxylase initializes salidroside biosynthesis. Metabolic characterization of tyrosine decarboxylase gene from Rhodiola crenulata (RcTYDC) revealed that it played an important role in salidroside biosynthesis. Recombinant 53 kDa RcTYDC converted tyrosine into tyramine. RcTYDC gene expression was induced coordinately with the expression of RcUDPGT (the last gene involved in salidroside biosynthesis) in SA/MeJA treatment; the expression of RcTYDC and RcUDPGT was dramatically upregulated by SA, respe… Show more

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Cited by 55 publications
(52 citation statements)
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“…TyrDC has a genotype and tissue dependent expression. Its expression is significantly higher in the roots than in leaves, stems or flowers in R. rosea and R. crenulata, which is in accordance with the high salidroside content it the roots Lan et al 2013). The salidroside content is significantly higher in transgenic hairy roots of the same species (Lan et al 2013), as well as in R.…”
Section: Para-coumaricsupporting
confidence: 66%
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“…TyrDC has a genotype and tissue dependent expression. Its expression is significantly higher in the roots than in leaves, stems or flowers in R. rosea and R. crenulata, which is in accordance with the high salidroside content it the roots Lan et al 2013). The salidroside content is significantly higher in transgenic hairy roots of the same species (Lan et al 2013), as well as in R.…”
Section: Para-coumaricsupporting
confidence: 66%
“…These challenges could be overcome by developing biotechnological methods to improve the production of R. rosea secondary metabolites through in vitro culture systems (Lan et al 2013;Mirmazloum et al 2014). However, the in vitro produced metabolites are in lower engineering is possible but dependent on the discovery of the genes expressing the relevant enzymes (Lan et al 2013).…”
Section: Rhodiola Rosea L (Synonymsmentioning
confidence: 99%
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