Engineering small molecule nanodrugs to overcome barriers for cancer therapy

Ma, Yuan; Mou, Quanbing; Yan, Deyue; Zhu, Xinyuan

doi:10.1002/viw.20200062

Cited by 28 publications

(17 citation statements)

References 129 publications

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“…Therefore, preventive strategies should be considered. For instance the use of nanodrugs or Janus particles have been described to allow for a better drug delivery and drug distribution across tumor tissue to avoid suboptimal local drug dosing and a subsequent selection of resistant clones (Su et al, 2019;Ma et al, 2020). In addition, the combination of anti-metabolic strategies with treatment modalities such as photodynamic or sonodynamic therapy using a different anti-neoplastic mechanism may add further therapeutic benefits and counteract therapeutic resistance (Wu et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

Dwucet¹,

Pruss²,

Cao³

et al. 2021

Front. Cell Dev. Biol.

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The purpose of this study was to examine whether the imipridone ONC201/TIC10 affects the metabolic and proliferative activity of medulloblastoma cells in vitro. Preclinical drug testing including extracellular flux analyses (agilent seahorse), MTT assays and Western blot analyses were performed in high and low c-myc-expressing medulloblastoma cells. Our data show that treatment with the imipridone ONC201/TIC10 leads to a significant inihibitory effect on the cellular viability of different medulloblastoma cells independent of c-myc expression. This effect is enhanced by glucose starvation. While ONC201/TIC10 decreases the oxidative consumption rates in D458 (c-myc high) and DAOY (c-myc low) cells extracellular acidification rates experienced an increase in D458 and a decrease in DAOY cells. Combined treatment with ONC201/TIC10 and the glycolysis inhibitor 2-Deoxyglucose led to a synergistic inhibitory effect on the cellular viability of medulloblastoma cells including spheroid models. In conclusion, our data suggest that ONC201/TIC10 has a profound anti-proliferative activity against medulloblastoma cells independent of c-myc expression. Metabolic targeting of medulloblastoma cells by ONC201/TIC10 can be significantly enhanced by an additional treatment with the glycolysis inhibitor 2-Deoxyglucose. Further investigations are warranted.

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Section: Discussionmentioning

confidence: 99%

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

Dwucet¹,

Pruss²,

Cao³

et al. 2021

Front. Cell Dev. Biol.

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“…Diverse types of nanomaterials have been prepared for the therapeutic use, serving as theranostic nanoplatforms, [ 188–190 ] assisting gene therapy [ 191,192 ] and ion‐interference therapy, [ 193,194 ] and acting as nanodrugs. [ 195,196 ] Biomass carbon materials stand out among the materials as a result of their excellent selectivity and high load effect, which are considered as the primary candidates for satisfied therapeutic effect in practical use. The natural carbon materials, such as porphyrins, perylenequinone, and curcumin, have been applied in photodynamic therapy (PDT) and sonodynamic therapy (SDT).…”

Section: The Application Of Sustainable Carbon Materials In Catalysismentioning

confidence: 99%

Sustainable Carbon Materials toward Emerging Applications

Lan

Yang

et al. 2021

Small Methods

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It is desirable for a sustainable society that the production and utilization of renewable materials are net‐zero in terms of carbon emissions. Carbon materials with emerging applications in CO2 utilization, renewable energy storage and conversion, and biomedicine have attracted much attention both academically and industrially. However, the preparation process of some new carbon materials suffers from energy consumption and environmental pollution issues. Therefore, the development of low‐cost, scalable, industrially and economically attractive, sustainable carbon material preparation methods are required. In this regard, the use of biomass and its derivatives as a precursor of carbon materials is a major feature of sustainability. Recent advances in the synthetic strategy of sustainable carbon materials and their emerging applications are summarized in this short review. Emphasis is made on the discussion of the original intentions and various sustainable strategies for producing sustainable carbon materials. This review provides basic insights and significant guidelines for the further design of sustainable carbon materials and their emerging applications in catalysis and the biomedical field.

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“…Therefore, the design of small molecules self-assembling into NPs to activate T 1 -weighted MR signals in response to specific biological stimuli has emerged. 75 Liang et al 76 took advantage of the controllable condensation reaction between 1,2-aminothiol and CBT dis-cussed above and designed a new activatable probe 1. In their work, when probes entered into locations rich in GSH, a condensation reaction was initiated, followed by the formation of gadolinium-containing NPs (Gd NPs).…”

Section: 22mentioning

confidence: 99%

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

Jin

Yang

et al. 2021

VIEW

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Magnetic resonance imaging (MRI) is a highly valuable diagnostic tool as it is a noninvasive technique that offers high spatial resolution. The use of contrast agents (CAs) can enhance the precision and specificity of MRI for disease diagnosis, but their imaging signals are "always on" regardless of whether they interact with target tissues or cells. Hence, a poor target-to-background signal ratio (TBR) is inevitably produced. In contrast, activatable CAs with high performance have been used to significantly improve the TBR, thus these CAs have also received extensive attention and undergone in-depth research. In this review, we summarized the recent advances in design strategies and principles of activatable MR CAs, including ion conversion, self-assembly, and disassembly. Additionally, we analyzed the advantages of these strategies in biomedical applications from in vitro biodetection to in vivo disease diagnosis compared to the outcomes of conventional MR CAs. Finally, we discussed the potential limitations, proposed solutions, and future perspectives of these activatable CAs. K E Y W O R D Sactivatable MR imaging, design strategies, target-to-background signal ratio, relaxivity, biomedical applications 1This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Engineering small molecule nanodrugs to overcome barriers for cancer therapy

Cited by 28 publications

References 129 publications

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

Sustainable Carbon Materials toward Emerging Applications

Emerging strategies of activatable MR imaging probes and their advantages for biomedical applications

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