Engineering the future with hydrogels: advancements in energy storage devices and biomedical technologies

Sharma, Amit Kumar; Sharma, Reetu; Pani, Balaram; Sarkar, Anjana; Tripathi, Mamta

doi:10.1039/d4nj00881b

New J. Chem.

2024

DOI: 10.1039/d4nj00881b

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Engineering the future with hydrogels: advancements in energy storage devices and biomedical technologies

Amit Kumar Sharma,

Reetu Sharma,

Balaram Pani

et al.

Abstract: Hydrogels, polymer networks with versatile applications in both energy-related devices and biomedicine, fall into three categories: natural, synthetic, and hybrid hydrogels. Natural variants like alginate and collagen boast biocompatibility, while...

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Cited by 3 publications

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A novel symmetrical mononuclear zinc complex: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculations, and application in a supercapacitor electrode

Lakhdari-Idir,

Ait Ramdane-Terbouche,

Terbouche

et al. 2024

New J. Chem.

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A novel symmetrical mononuclear zinc complex: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculations, and application in a supercapacitor electrode

Lakhdari-Idir,

Ait Ramdane-Terbouche,

Terbouche

et al. 2024

New J. Chem.

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Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing

Liu,

Sharma,

et al. 2024

Pharmaceutics

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Background: Skin ageing, driven predominantly by oxidative stress from reactive oxygen species (ROS) induced by environmental factors like ultraviolet A (UVA) radiation, accounts for approximately 80% of extrinsic skin damage. L-glutathione (GSH), a potent antioxidant, holds promise in combating UVA-induced oxidative stress. However, its instability and limited penetration through the stratum corneum hinder its topical application. This study introduces a novel solid lipid nanoparticle (SLN)-enriched hydrogel designed to enhance GSH stability, skin penetration, and sustained release for anti-ageing applications. Methods: GSH-loaded SLNs were prepared via a double-emulsion technique and optimized using factorial design. These SLNs were incorporated into 1–3% (w/v) Carbopol hydrogels to produce a semi-solid formulation. The hydrogel’s characteristics, including morphology, mechanical and rheological properties, drug release, stability, antioxidant activity, cytotoxicity, and skin penetration, were evaluated. Results: SEM and FTIR confirmed the uniform dispersion of SLNs within the hydrogel. The formulation exhibited desirable properties, including gel strength (5.1 ± 0.5 g), spreadability (33.6 ± 1.9 g·s), pseudoplasticity, and elasticity. In vitro studies revealed a biphasic GSH release profile, with sustained release over 72 h and over 70% cumulative release. The hydrogel significantly improved antioxidant capacity, protecting human fibroblasts from UVA-induced oxidative stress and enhancing cell viability. Stability studies indicated that 4 °C was optimal for storage over three months. Notably, the hydrogel enhanced GSH penetration through the stratum corneum by 3.7-fold. Conclusions: This SLN-enriched hydrogel effectively improves GSH topical delivery and antioxidant efficacy, providing a promising platform for anti-ageing and other bioactive compounds with similar delivery challenges.

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Influence of High Strain Dynamic Loading on HEMA–DMAEMA Hydrogel Storage Modulus and Time Dependence

Cook-Chennault,

Anaokar,

Medina Vázquez

et al. 2024

Polymers

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Hydrogels have been extensively studied for biomedical applications such as drug delivery, tissue-engineered scaffolds, and biosensors. There is a gap in the literature pertaining to the mechanical properties of hydrogel materials subjected to high-strain dynamic-loading conditions even though empirical data of this type are needed to advance the design of innovative biomedical designs and inform numerical models. For this work, HEMA–DMAEMA hydrogels are fabricated using a photopolymerization approach. Hydrogels are subjected to high-compression oscillatory dynamic mechanical loading at strain rates equal to 50%, 60%, and 70%, and storage and loss moduli are observed over time, e.g., 72 h and 5, 10, and 15 days. As expected, the increased strains resulted in lower storage and loss moduli, which could be attributed to a breakdown in the hydrogel network attributed to several mechanisms, e.g., increased network disruption, chain scission or slippage, and partial plastic deformation. This study helps to advance our understanding of hydrogels subjected to high strain rates to understand their viscoelastic behavior, i.e., strain rate sensitivity, energy dissipation mechanisms, and deformation kinetics, which are needed for the accurate modeling and prediction of hydrogel behavior in real-world applications.

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Engineering the future with hydrogels: advancements in energy storage devices and biomedical technologies

Abstract: Hydrogels, polymer networks with versatile applications in both energy-related devices and biomedicine, fall into three categories: natural, synthetic, and hybrid hydrogels. Natural variants like alginate and collagen boast biocompatibility, while...

Cited by 3 publications

References 185 publications

A novel symmetrical mononuclear zinc complex: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculations, and application in a supercapacitor electrode

A novel symmetrical mononuclear zinc complex: synthesis, crystal structure, Hirshfeld surface analysis, DFT calculations, and application in a supercapacitor electrode

Innovative Solid Lipid Nanoparticle-Enriched Hydrogels for Enhanced Topical Delivery of L-Glutathione: A Novel Approach to Anti-Ageing

Influence of High Strain Dynamic Loading on HEMA–DMAEMA Hydrogel Storage Modulus and Time Dependence

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