Engineering the surface functionality of 45S5 bioactive glass-based scaffolds by the heterogeneous nucleation and growth of silver particles

Meincke, Thomas; Pacheco, Valentina Miguez; Hoffmann, Daniel; Boccaccını, Aldo R.; Taylor, Robin N. Klupp

doi:10.1007/s10853-017-0877-0

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Surface modification was assessed by FTIR analysis. In vitro results confirmed that the silver coating does not interfere with the apatite-formation process, since a typical cauliflower-like HA layer was observed on the surface of the scaffolds after soaking for 3 days in Simulated Body Fluid (SBF) [ 34 ].…”

Section: Bgs: a Historical Overviewmentioning

confidence: 84%

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Fiume

Barberi

Verné

et al. 2018

JFB

230

100

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Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide. Moreover, recent studies show the effectiveness of BGs in the regeneration of soft tissues, too. Often, surgical criteria do not match the engineering ones and, thus, a compromise is required for getting closer to an ideal outcome in terms of good regeneration, mechanical support, and biocompatibility in contact with living tissues. The aim of the present review is providing a general overview of BGs, with particular reference to their use in clinics over the last decades and the latest synthesis/processing methods. Recent advances in the use of BGs in tissue engineering are outlined, where the use of porous scaffolds is gaining growing importance thanks to the new possibilities given by technological progress extended to both manufacturing processes and functionalization techniques.

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Section: Bgs: a Historical Overviewmentioning

confidence: 84%

Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies

Fiume

Barberi

Verné

et al. 2018

JFB

230

100

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“…Various approaches for tuning the dissolution rate of glasses are currently being investigated, such as intrinsic composition optimization involving growth of silver particles, rare-earth introduction, and substitution of elements. − However, around 3/5 of the atoms in most oxide glasses are oxygens and the possibilities for property tuning are thus relatively limited. Many efforts are therefore also focusing on various post-treatment methods, such as cold and hot solution treatment, fire polishing, gaseous-reagent treatment, coating with polymers as grafting-from method, coating with metal, and SO 2 surface treatment .…”

Section: Introductionmentioning

confidence: 99%

Dissolution Kinetics of Hot Compressed Oxide Glasses

et al. 2017

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The chemical durability of oxide glasses is an important property for a wide range of applications and can in some cases be tuned through composition optimization. However, these possibilities are relatively limited because around 3/5 of the atoms in most oxide glasses are oxygens. An alternative approach involves post-treatment of the glass. In this work, we focus on the effect of hot compression on dissolution kinetics because it is known to improve, for example, elastic moduli and hardness, whereas its effect on chemical durability is poorly understood. Specifically, we study the bulk glass dissolution rate of phosphate, silicophosphate, borophosphate, borosilicate, and aluminoborosilicate glasses, which have been compressed at 0.5, 1.0, and 2.0 GPa at the glass transition temperature (T). We perform weight loss and supplementary modifier leaching measurements of bulk samples immersed in acid (pH 2) and neutral (pH 7) solutions. Compression generally improves the chemical durability as measured from weight loss, but the effect is highly composition- and pressure-dependent. As such, we show that the dissolution mechanisms depend on the topological changes induced by permanent densification, which in turn are a function of the changes in the number of nonbridging oxygens and the network cross-linking. We also demonstrate a direct relationship between the chemical durability and the number of chemical topological constraints per atom (n) acting within the molecular network.

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“…Bioactive glasses are frequently combined with other materials to form composites or hybrids for a broad range of applications. Such composite systems are also featured in other papers within this special section, for example bioactive glass-biopolymer composites [24][25][26], hybrids [27], Ag-coated bioactive glass scaffolds [28] and antibiotic-releasing biopolymer-bioactive glass films [29]. Bioactive glasses are considered as coating materials for different substrates to provide surface bioactivity, and this aspect is covered in papers describing different coating methods involving bioactive glasses on a variety of substrates [30][31][32][33][34].…”

Section: ó Springer Science+businessmentioning

confidence: 99%