2023
DOI: 10.1021/acsnano.3c01994
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Engineering U1-Based Tetracycline-Inducible Riboswitches to Control Gene Expression in Mammals

Eric Rovira,
Beatriz Moreno,
Nerea Razquin
et al.

Abstract: Synthetic riboswitches are promising regulatory devices due to their small size, lack of immunogenicity, and ability to fine-tune gene expression in the absence of exogenous trans-acting factors. Based on a gene inhibitory system developed at our lab, termed U1snRNP interference (U1i), we developed tetracycline (TC)-inducible riboswitches that modulate mRNA polyadenylation through selective U1 snRNP recruitment. First, we engineered different TC-U1i riboswitches, which repress gene expression unless TC is adde… Show more

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