Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy

Liang, Jing; Qiao, Xiaohui; Qiu, Luping; Xu, Huning; Xiang, Huijing; Ding, Hong; Chen, Yu

doi:10.1002/advs.202305392

Cited by 13 publications

(2 citation statements)

References 162 publications

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“…Nanocarriers can be designed to simultaneously carry sonosensitizers and immunostimulatory molecules, such as CpG oligodeoxynucleotides. This design aims to kill tumor cells through SDT while activating toll-like receptor 9 with CpG, further activating DCs and T cells to enhance the anti-tumor immune response [86]. Lin et al developed a multifaceted nanosonosensitizer, TiO 2 -Ce6-CpG, by amalgamating titanium dioxide (TiO 2 ) NPs with the sonosensitizer Ce6 and immune adjuvant CpG oligodeoxynucleotides.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

Advances in Nanodynamic Therapy for Cancer Treatment

Zhang,

Huang,

Huang

2024

Nanomaterials

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Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity by leveraging the tumor microenvironment (TME) and mechanisms that boost anti-tumor immune responses. It also minimizes damage to surrounding healthy tissues and enhances cytotoxicity in tumor cells, showing promise in cancer treatment, with significant potential. This review covers the research progress in five major nanodynamic therapies: photodynamic therapy (PDT), electrodynamic therapy (EDT), sonodynamic therapy (SDT), radiodynamic therapy (RDT), and chemodynamic therapy (CDT), emphasizing the significant role of advanced nanotechnology in the development of NDT for anti-tumor purposes. The mechanisms, effects, and challenges faced by these NDTs are discussed, along with their respective solutions for enhancing anti-tumor efficacy, such as pH response, oxygen delivery, and combined immunotherapy. Finally, this review briefly addresses challenges in the clinical translation of NDT.

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Section: Sonodynamic Therapymentioning

confidence: 99%

Advances in Nanodynamic Therapy for Cancer Treatment

Zhang,

Huang,

Huang

2024

Nanomaterials

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“…The favorable properties of nanobubbles (NBs), such as their size and ease of modification, have now been exploited to implement a theranostic platform for cancer treatment. [1][2][3][4] NB backbone-based nanotechnologies are focusing on their fabrication as an ideal tool due to their capacity for passive targeting via the enhanced permeability and retention (EPR) effect 5,6 and active targeting by functionalizing specific targeting ligands on the surfaces of NBs while transporting and controlling drug or gene delivery, thereby offering therapeutic potential. [7][8][9][10] However, when applied as ultrasound contrast agents (UCA), NBs commonly exhibit lower contrast signals compared to microbubbles due to the reduced scattering cross-section of a single bubble.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Tumor-Targeting Nanobubble with Multiple Scattering Interfaces and its Enhancement of Ultrasound Imaging

Ma,

Zhang,

Zhu

et al. 2024

IJN

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Introduction:Recently, nanobubbles (NBs) have gained significant traction in the field of tumor diagnosis and treatment owing to their distinctive advantages. However, the application of NBs is limited due to their restricted size and singular reflection section, resulting in low ultrasonic reflection. Methods: We synthesized a nano-scale ultrasound contrast agent (IR783-SiO 2 NPs@NB) by encapsulating SiO 2 nanoparticles in an IR783-labeled lipid shell using an improved film hydration method. We characterized its physicochemical properties, examined its microscopic morphology, evaluated its stability and cytotoxicity, and assessed its contrast-enhanced ultrasound imaging capability both in vitro and in vivo. Results:The results show that IR783-SiO 2 NPs@NB had a "donut-type" composite microstructure, exhibited uniform particle size distribution (637.2 ± 86.4 nm), demonstrated excellent stability (30 min), high biocompatibility, remarkable tumor specific binding efficiency (99.78%), and an exceptional contrast-enhanced ultrasound imaging capability. Conclusion: Our newly developed multiple scattering NBs with tumor targeting capacity have excellent contrast-enhanced imaging capability, and they show relatively long contrast enhancement duration in solid tumors, thus providing a new approach to the structural design of NBs.

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Flying‐Saucer‐Shaped Nanoheterojunctions with Enhanced Colorectal Tumor Accumulation for Increased Oxidative Stress and Immunometabolic Regulation

Ma,

Cao,

et al. 2024

Adv Funct Materials

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The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions by coating copper oxide (CuxO) onto the surface of PEGylated zinc oxide (ZnO) nanoparticles are constructed. When exposed to ultrasound, the resultant CuxO@ZnO nanoheterojunctions exhibit increased locomotor activities, facilitating colorectal mucus infiltration, deep tumor penetration, and tumor cell internalization. The decoration of CuxO suppresses the rapid recombination of electrons and holes in CuxO@ZnO exposed to ultrasound, promoting the production of singlet oxygen and hydroxyl radical, which are generated by CuxO through a Fenton‐like chemodynamic reaction and CuxO@ZnO through sonodynamic reaction. After rectal administration, the sono‐chemodynamic CuxO@ZnO plus PD‐L1 antibodies effectively inhibit the growth of orthotopic and distant tumors. It elicits immunometabolic responses by inducing immunogenic cell death, activating the interferon genes signaling pathway stimulator, and inhibiting glucose transport and the glycolytic signaling pathways. This combined modality also increases the proportion of beneficial microbes (e.g., Bifidobacterium) and decreases the abundance of harmful microorganisms (e.g., Romboutsia) in the intestine. This treatment modality (CuxO@ZnO plus ultrasound and PD‐L1 antibodies) is a promising strategy for the synergistic treatment of colorectal cancer.

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Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy

Cited by 13 publications

References 162 publications

Advances in Nanodynamic Therapy for Cancer Treatment

Advances in Nanodynamic Therapy for Cancer Treatment

Construction of a Tumor-Targeting Nanobubble with Multiple Scattering Interfaces and its Enhancement of Ultrasound Imaging

Flying‐Saucer‐Shaped Nanoheterojunctions with Enhanced Colorectal Tumor Accumulation for Increased Oxidative Stress and Immunometabolic Regulation

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