2022
DOI: 10.1101/2022.08.16.504081
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ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

Abstract: In addition to their cell-autonomous activities, a number of homeoprotein transcription factors transfer between cells and regulate gene expression, protein translation and chromatin organization in a non-cell autonomous way. ENGRAILED-1 is one such homeoprotein and is expressed in spinal V1 interneurons that synapse on α-motoneurons. Neutralizing extracellular ENGRAILED-1 by expressing a secreted single chain antibody blocks its capture by spinal motoneurons and induces the loss of neuromuscular strength and … Show more

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