2020
DOI: 10.1186/s12935-020-1145-y
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Engrailed 2 (EN2) acts as a glioma suppressor by inhibiting tumor proliferation/invasion and enhancing sensitivity to temozolomide

Abstract: Background: Glioma is one of the most malignant brain tumors and accounts for the majority of brain cancer related death. Despite progress on mechanistic studies, current understandings of the initiation and progression of glioma are still incomplete. Previous studies demonstrate that Engrailed-2 (EN2), a homeobox-containing transcription factor, is associated with tumorigenesis in a range of cancers heterogeneously, however, the profiles of EN2 expression and its potential functions in gliomas remain unclear.… Show more

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Cited by 14 publications
(8 citation statements)
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“…Patients with LGGs have a more favorable prognosis than those with GBM, but many advances to higher-grade gliomas, resulting in recurrence and poor survival, posing a therapeutic challenge to physicians ( 37 39 ).Despite standard treatment of maximally safe surgical resection followed by radiotherapy and adjuvant chemotherapy with temozolomide, the prognosis of glioma, particularly glioblastoma, remains poor and almost all patients relapse inevitably ( 40 , 41 ). Identifying new prognostic markers of LGGs at an early stage of the tumor, thus, can successfully predict and enhance the clinical prognosis of glioma patients.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with LGGs have a more favorable prognosis than those with GBM, but many advances to higher-grade gliomas, resulting in recurrence and poor survival, posing a therapeutic challenge to physicians ( 37 39 ).Despite standard treatment of maximally safe surgical resection followed by radiotherapy and adjuvant chemotherapy with temozolomide, the prognosis of glioma, particularly glioblastoma, remains poor and almost all patients relapse inevitably ( 40 , 41 ). Identifying new prognostic markers of LGGs at an early stage of the tumor, thus, can successfully predict and enhance the clinical prognosis of glioma patients.…”
Section: Discussionmentioning
confidence: 99%
“…EN2 overexpression impedes the multiplication and metastasis of NSCLC cells [ 30 ]. EN2 is under-expressed in gliomas, and elevated EN2 expression restrains cell multiplication, enhances tumor sensitivity to temozolomide, and blocks tumor cell invasion by repressing MMP9 expression [ 31 ]. Conversely, in ovarian cancer, high EN2 expression predicts the adverse prognosis of the patients [ 18 ].…”
Section: Discussionmentioning
confidence: 99%
“…To detect the effect of MTCH2 on cell migration of glioma cells, we performed scratch wound healing assay as previous described (Li et al 2020 ). Briefly, glioma cells were seeded in 6-wells plate overnight, and then siRNA MTCH2 were transfected into cells when cells reached at least 90% density.…”
Section: Methodsmentioning
confidence: 99%