Enhance the Bioactivity and Osseointegration of the Polyethylene‐Terephthalate‐Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

Abstract

The objective of this study is to study the bioactivity and osseointegration of polyethyleneterephthalate-based artificial ligament coated with mesoporous bioactive glass (MBG) via polydopamine (PDA) in vitro and in vivo. In vitro, the OD value of MC3T3-E1 cells on PDA-MBG modified grafts is around 108% higher than that on pure PET after 5 days of culturing. The ALP activity of the PDA-MBG group is about 1.5 times higher than that of the control group after 7 days of culturing. In the in vivo study, the results demonstrated that more newly formed bone tissue was found and the ultimate failure load increased in the PDA-MBG coating group. In conclusion, PDA and MBG coating improves the surface bioactivity of the polyethylene-terephthalate-based artificial ligament and enhances the osseointegration within a bone tunnel.

Evaluation of bone marrow stem cell response to PLA scaffolds manufactured by 3D printing and coated with polydopamine and type I collagen

“…Several studies point to PDA coating as a tool to enhance osteogenesis in different scaffold systems . The increase in ALP production by MSCs seeded onto the DOPA COL scaffolds is in general agreement with the literature and indicates that, although there is no significant difference in cell proliferation and ECM compound deposition from PLA scaffolds, the PDA and COL coating can stimulate the early stages of osteogenic differentiation, acting as a key to stimulate bone tissue regeneration …”

“…PDA functionalization is proposed as a simple and robust platform for covalent immobilization of proteins and other biomolecules on to the surface of printed scaffolds. As observed in Figure , the PDA layer was easily created on the surface of PLA scaffolds, and it was possible to observe the same behavior of carbon distribution as that observed by Cheng et al (2016) for PCL scaffolds immobilized with PDA. The differences in the relative areas of C1s deconvoluted peaks for PDA coated scaffolds are related to the large amount of hydroxyl groups of dopamine and the expressive increase in the peak 3 (C–O) area for DOPA COL.…”

Is it Possible to Use Rolling Methods to Improve Textures on Fe–Mn–Si Shape Memory Alloys?

“…A feature of stress‐induced martensite is the curved shape of the plates. Such an aspect distinguishes this martensitic form from thermal martensite, where the plates stop at the grain boundaries and the austenite‐martensite interface is more strongly defined . The refined plate morphology corresponds to a matrix with a high defect density, as it will be seen in TEM images.…”

“…Looking for shear texture, many authors studied the effect of various rolling techniques as symmetric, asymmetric, continuous, snake, and reversed rolling in different materials . Equal Channel Angular Extrusion (ECAE), is also a fundamentally shearing deformation process, used for developing characteristic textures on many metals and alloys …”

Organosilicon polymer-derived ceramics: An overview

“…3D printing is a good choice to fabricate special structured materials due to the precise design and control for the architecture and structure by computer aided design (CAD) and computer aided manufacturing (CAM) [75][76][77][78][79][80][81][82], which has been utilized in fabricating polymer-derived ceramics in recent years due to its ability to control the architecture or porous structure precisely. According to the different shaping principles, 3D printing technique can be divided into six modes, which include modeling (FDM), stereolithography (SLA), selective laser sintering (SLS), powder-based printing (PB), inkjet printing (IP), and direct ink writing (DIW).…”