1972
DOI: 10.1002/jps.2600610316
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Enhanced Absorption and Dissolution of Reserpine from Reserpine-Polyvinylpyrrolidone Coprecipitates

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Cited by 45 publications
(12 citation statements)
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“…The samples were centrifuged at 5000 rpm for 15 min in order to remove fine particles. The supernatants from each sample were taken, diluted and subjected for the quantification of reserpine content using UV-Visible spectrophotometer at 268 nm [17]. The proposed spectrophotometric method was observed linear over the concentration range of (2 to 20) lg Á g À1 .…”
Section: Measurement Of Reserpine Solubilitymentioning
confidence: 99%
See 1 more Smart Citation
“…The samples were centrifuged at 5000 rpm for 15 min in order to remove fine particles. The supernatants from each sample were taken, diluted and subjected for the quantification of reserpine content using UV-Visible spectrophotometer at 268 nm [17]. The proposed spectrophotometric method was observed linear over the concentration range of (2 to 20) lg Á g À1 .…”
Section: Measurement Of Reserpine Solubilitymentioning
confidence: 99%
“…Recently, 2-(2-ethoxyethoxy)ethanol (Transcutol Ò ) has been investigated as an efficient co-solvent for solubility enhancement of several poorly water-soluble drugs [9][10][11][12][13][14][15]. Various attempts via co-precipitation, solid dispersion and co-solvency approach have been made in order to enhance solubility and dissolution rate enhancement of reserpine [7,8,[16][17][18]. However, the thermodynamics of solubility of reserpine in various {2-(2-ethoxyethoxy)ethanol + water} mixed solvent systems have not been reported in literature.…”
Section: Introductionmentioning
confidence: 99%
“…The mechanisms of increased dissolution rates of drugs solid dispersed in povidone carriers were reviewed (10). Additional studies supported the significance of the solid dispersion technique (11)(12)(13)(14)(15)(16)(17)(18)(19).The concept of glass solutions was introduced recently to increase dissolution rates (14). This concept also was discussed in an extensive review of the pharmaceutical applications of solid dispersions (20).…”
mentioning
confidence: 90%
“…The mechanisms of increased dissolution rates of drugs solid dispersed in povidone carriers were reviewed (10). Additional studies supported the significance of the solid dispersion technique (11)(12)(13)(14)(15)(16)(17)(18)(19).…”
mentioning
confidence: 92%
“…Class II drugs are considered the best candidates for intervention by formulation, and several methods have been developed to overcome their low aqueous solubility. Salt formation, pH adjustment, and complexation are wellknown strategies for solubility enhancement, though their use is restricted to a considerably small group of molecules (4,5). Stupak and Bates (6) have reported other ways to improve drug dissolution in aqueous media that include particle size reduction and the addition of solubilizing agents that can promote wettability and increase drug saturation solubility locally.…”
mentioning
confidence: 99%