Enhanced activity of Ellagic acid in lipid nanoparticles (EA-liposomes) against Acinetobacter baumannii in immunosuppressed mice

Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

“…The bronchoalveolar fluid (BALF) from infected mice contained greater quantities of IL-6, IL-1b, and TNF-a, which were significantly alleviated in mice treated with EA. These results support the possible implication of EA-liposomes in the treatment of A. baumannii infection, especially in immunocompromised mice [244].…”

Investigating the anti-growth, anti-resistance, and anti-virulence activities of Schoepfia schreberi J.F.Gmel. against the superbug Acinetobacter baumannii

“…Recent studies have shown that EA, is effective against A. baumannii and can be used into lipid nanoparticles. Results from an immunocompromised mouse model showed improved survival and reduced bacterial load in the lungs, indicating that EA liposomes may provide better treatment for A. baumannii infections than commonly used antibiotics [ 47 ]. Ble-González et al (2022) reported that leaves extract of Acalypha arvensis which contained EA was active against S. aureus , K. pneumoniae and P. aeruginosa [ 48 ].…”

“…Sherif et al reported that GA sub-growth-inhibitory concentrations (660–1055 μg/mL) inhibited biofilm formation (36.34–90.67 %) in a group of clinical isolates of A. baumannii [ 64 ]. Additionally, EA, both in its pure form and in a liposomal formulation at a concentration of 32 μg/mL, effectively inhibited biofilm formation by A. baumannii ATCC-19606 by 72.3 % and 60 %, respectively [ 47 ]. These discrepancies in activity may be attributed to the strain tested, as it has been previously established that the anti-biofilm activity of a compound can vary among different bacteria [ 64 ].…”