Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation

Coppieters, Iris; Cagnie, Barbara; Pauw, Robby De; Meeus, Mira; Timmers, Inge

doi:10.1016/j.nicl.2021.102638

Cited by 12 publications

(16 citation statements)

References 109 publications

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“…Regarding the FC of the right precentral, we found that the connection with the precuneus, cingulate, and left paracentral lobule increased. Our results support previous research, these brain areas play an important role in chronic pain-related diseases ( 37 , 45 – 47 ). The cingulate gyrus is related to various cognitive, social, and emotional functioning ( 45 ).…”

Section: Discussionsupporting

confidence: 93%

“…However, we cannot confirm this view because the emotional/cognitive ability of patients was not measured in this study. The precuneus is part of a group of areas related to the neurological characteristics of pain ( 36 ) and acts as an antinociceptive region ( 37 ) and increased FC in the precentral gyrus with the superior parietal cortex in patients with CNP ( 47 ). However, in present results, no brain areas with FC were reported with left precentral, it is reasonable to speculate that there may also exist functional asymmetry in the precentral gyrus in patients with CSP.…”

Section: Discussionmentioning

confidence: 99%

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Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain

Wei

Shi

et al. 2022

Front. Neurol.

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ObjectiveThe purpose of this study was to explore the structural and functional asymmetry of precentral and postcentral gyrus in patients with unilateral chronic shoulder pain (CSP) utilizing MRI.Patients and MethodsWe collected structural and resting-state functional MRI (rs-fMRI) data in 22 left-sided, 15 patients with right-sided CSP, and 24 healthy controls (HCs). Here, we performed the structural asymmetry and seed-based functional connectivity (FC) analyses. We extracted regional cortical thickness and surface area measurements from T1-weighted MRI images, using asymmetry indexes (AIs) to assess asymmetries. We used Data Processing and Analysis for Brain Imaging software for seed-based FC analysis and selected unilateral-precentral and postcentral as the regions of interest. Then, we performed group comparisons of the neuroimaging metrics, and also explored the relationships between brain asymmetry and clinical variables.ResultsWe found significant differences in surface area AIs of the precentral among three groups, the AI values were negatively correlated with the visual analog scale score and positively correlated with Constant–Murley scores (CMS) in the left-sided CSP group. Further, FC of left postcentral with cingulate gyrus and left paracentral lobule showed significant group differences; FC of right postcentral with left caudate, left paracentral, and left postcentral were different among groups; FC of right precentral with the cingulate gyrus, precuneus, and left paracentral revealed significant group differences. Besides, there was a positive correlation between right precentral-cingulate gyrus FC and CMS in the right-sided CSP group.ConclusionSurface area and FC patterns asymmetry exist in precentral and postcentral gyrus in patients with unilateral CSP. Asymmetry trend is associated with pain severity and shoulder joint function impairment. Brain structural and functional asymmetry may be an important indicator for understanding the potential mechanism of chronic pain.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain

Wei

Shi

et al. 2022

Front. Neurol.

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“…These patients also had more efficient CPM responses. 7 Because of different focus points, findings across these rsFC studies are quite heterogenous. At first sight, however, findings seem in line with findings of the studies that assessed brain function during the CPM response.…”

Section: Resting-state Functional Connectivity In Relation To the Con...mentioning

confidence: 99%

Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies

Nahman‐Averbuch

Timmers

2022

Pain

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Processing spatially distributed nociceptive information is critical for survival. The conditioned pain modulation (CPM) response has become a common psychophysical test to examine pain modulation capabilities related to spatial filtering of nociceptive information. Neuroimaging studies have been conducted to elucidate the neural mechanisms underlying the CPM response in health and chronic pain states, yet their findings have not been critically reviewed and synthesized before. This narrative review presents a simplified overview of MRI methodology in relation to CPM assessments and summarizes the findings of neuroimaging studies on the CPM response. The summary includes functional MRI studies assessing CPM responses during scanning as well as functional and structural MRI studies correlating indices with CPM responses assessed outside of the scanner. The findings are discussed in relation to the suggested mechanisms for the CPM response. A better understanding of neural mechanisms underlying spatial processing of nociceptive information could advance both pain research and clinical use of the CPM response as a marker or a treatment target.

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“…Their findings indicated that preoperative endogenous pain modulation deficiency might be associated with axial pain after posterior cervical decompression [9]. It is not surprising that DCM patients developed abnormal pain modulation system, considering most of the patients experienced chronic pain that is associated with modifications of the central nervous system, such as central sensitization, which is responsible for alterations in pain sensitivity in acute and chronic pain situations [26][27][28]. We also found that preoperative pain threshold was negatively correlated with pre/post-operative pain intensity and preoperative pain intensity was positively correlated with postoperative pain intensity in DCM patients.…”

Section: Discussionmentioning

confidence: 99%

Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study

Chu

et al. 2023

Insights Imaging

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Objective To test whether preoperative pain sensitivity is associated with the postoperative axial pain (PAP) in degenerative cervical myelopathy (DCM) and to explore its underlying brain mechanism. Methods Clinical data and resting-state fMRI data of 62 DCM patients along with 60 age/gender matched healthy participants were collected and analysed. Voxel-wise amplitude of low frequency fluctuation (ALFF) was computed and compared between DCM patients and healthy controls. Correlation analyses were performed to reveal the association between the clinical metrics and brain alterations. Clinical data and ALFF were also compared between DCM patients with PAP and without PAP. Results (1) Relative to healthy participants, DCM patients exhibited significantly lower preoperative pain threshold which is associated with the PAP intensity; (2) Relative to patients without PAP, PAP patients exhibited increased ALFF in mid-cingulate cortex (MCC) and lower preoperative pain threshold; (3) Further, multivariate pattern analysis revealed that MCC ALFF provide additional value for PAP vs. non-PAP classification. Conclusion In conclusion, our findings suggest that preoperative pain hypersensitivity may be associated with postoperative axial pain in degenerative cervical myelopathy patients. This finding may inspire new therapeutic ideas for patients with preoperative axial pain.

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Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation

Cited by 12 publications

References 109 publications

Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain

Structural and Functional Asymmetry in Precentral and Postcentral Gyrus in Patients With Unilateral Chronic Shoulder Pain

Neural mechanisms underlying the conditioned pain modulation response: a narrative review of neuroimaging studies

Preoperative pain hypersensitivity is associated with axial pain after posterior cervical spinal surgeries in degenerative cervical myelopathy patients: a preliminary resting-state fMRI study

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