Enhanced anesthetic propofol biochips by modifying molecularly imprinted nanocavities of biosensors

Hong, Chien-Chong; Lin, Chih‐Chung; Hong, Chian-Lang; Chang, Po Hsiang

doi:10.1007/s10544-011-9620-9

Cited by 13 publications

(4 citation statements)

References 20 publications

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“…Microfluidics, also known as lab-on-a-chip systems, is the technology that processes small amounts of liquids with channels of tens to hundreds of micrometer sizes [93]. Molecularly imprinted polymers have been successfully integrated with lab-on-a-chip systems for a wide variety of applications [94,95]. Despite the conventional microfluidic strategies, the molecularly imprinted polymers have been leveraging the performance of these systems by increasing chemical reactivity; providing higher surface area; creating specific binding regions to target molecules; increasing the binding capacity; and forming homogeneous spherical geometry [96].…”

Section: Lab-on-a-chip Systemsmentioning

confidence: 99%

Advances in Biomimetic Systems for Molecular Recognition and Biosensing

et al. 2020

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Understanding the fundamentals of natural design, structure, and function has pushed the limits of current knowledge and has enabled us to transfer knowledge from the bench to the market as a product. In particular, biomimicry―one of the crucial strategies in this respect―has allowed researchers to tackle major challenges in the disciplines of engineering, biology, physics, materials science, and medicine. It has an enormous impact on these fields with pivotal applications, which are not limited to the applications of biocompatible tooth implants, programmable drug delivery systems, biocompatible tissue scaffolds, organ-on-a-chip systems, wearable platforms, molecularly imprinted polymers (MIPs), and smart biosensors. Among them, MIPs provide a versatile strategy to imitate the procedure of molecular recognition precisely, creating structural fingerprint replicas of molecules for biorecognition studies. Owing to their affordability, easy-to-fabricate/use features, stability, specificity, and multiplexing capabilities, host-guest recognition systems have largely benefitted from the MIP strategy. This review article is structured with four major points: (i) determining the requirement of biomimetic systems and denoting multiple examples in this manner; (ii) introducing the molecular imprinting method and reviewing recent literature to elaborate the power and impact of MIPs on a variety of scientific and industrial fields; (iii) exemplifying the MIP-integrated systems, i.e., chromatographic systems, lab-on-a-chip systems, and sensor systems; and (iv) closing remarks.

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Section: Lab-on-a-chip Systemsmentioning

confidence: 99%

Advances in Biomimetic Systems for Molecular Recognition and Biosensing

et al. 2020

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“…Furthermore, microfluidic systems have been frequently used for the nanoparticle and nanofilm immobilization. These nanomaterials have exclusively been used in MIP-based microfluidic systems for different applications, such as quartz crystal microbalances, surface plasmon resonance, and colorimetric and fluorescence sensors [41,42].…”

Section: Integrations Of Mips With Microfluidic Systemsmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Microfluidic Systems for Point-of-Care Applications

Saylan

Deni̇zli̇

2019

Micromachines

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Fast progress has been witnessed in the field of microfluidic systems and allowed outstanding approaches to portable, disposable, low-cost, and easy-to-operate platforms especially for monitoring health status and point-of-care applications. For this purpose, molecularly imprinted polymer (MIP)-based microfluidics systems can be synthesized using desired templates to create specific and selective cavities for interaction. This technique guarantees a wide range of versatility to imprint diverse sets of biomolecules with different structures, sizes, and physical and chemical features. Owing to their physical and chemical robustness, cost-friendliness, high stability, and reusability, MIP-based microfluidics systems have become very attractive modalities. This review is structured according to the principles of MIPs and microfluidic systems, the integration of MIPs with microfluidic systems, the latest strategies and uses for point-of-care applications and, finally, conclusions and future perspectives.

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“…Molecular imprinting is an effective technique to produce specific recognition sites that are chemically and sterically complementary in shape, size and functionality to the target molecules in polymer networks. Owing to the advantages, such as good physical, chemical, and thermal stability, high selectivity, and strong affinity, molecular imprinted technology have been applied in wide fields, including bioseparation, 1 solid phase extraction, 2 biosensors, 3,4 chromatography, 5,6 and drug delivery. 7,8 So far, molecular imprinted technology has been successfully applied for the analysis, detection, and separation of a wide range of small molecules.…”

Section: Introductionmentioning

confidence: 99%