Enhanced Anti-Inflammatory Activity of Tilianin Based on the Novel Amorphous Nanocrystals
Min Sun,
Mengran Guo,
Zhongshan He
et al.
Abstract:Tilianin (Til), a flavonoid glycoside, is well-known for its therapeutic promise in treating inflammatory disorders. Its poor water solubility and permeability limit its clinical applicability. In order to overcome these restrictions, an antisolvent precipitation and ultrasonication technique was used to prepare amorphous tilianin nanocrystals (Til NCs). We have adjusted the organic solvents, oil-to-water ratio, stabilizer composition, and ultrasonic power and time by combining single-factor and central compos… Show more
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