The use of blended concrete has widely gained industrial importance owing to the CO2 gas emissions and carbon footprint resulting from the production of ordinary Portland cement (OPC). Despite the advancements, the deterioration of concrete structures raises a significant threat to their long term durability and service life in aggressive conditions. In this work, the long-term antifouling, strength and durability properties of a blended eco-friendly concrete with OPC, fly ash, nanoparticles, and corrosion inhibitor is evaluated in natural seawater for one year. The biofouling attachment, total viability count (TVC), mechanical strength, alkalinity and free chloride contents were measured and the results were compared with OPC concrete. A four-order reduction in the total biomass and total bacterial density is observed on the surface of the blended concrete. Further, a significantly lower chloride and water penetration depth, free chloride content, compact and smooth surface morphology devoid of cracks and high C-S-H content are observed in blended concrete, compared to the OPC concrete, after exposure in seawater for one year. From the results, it is seen that the blended concrete mix is promising for applications in seawater environments because of its superior biofouling resistance, mechanical properties and durability.