Enhanced antibacterial activity and superior biocompatibility of cobalt-deposited titanium discs for possible use in implant dentistry

Madiwal, Vaibhav; Khairnar, Bhushan; Rajwade, Jyutika

doi:10.1016/j.isci.2024.108827

Cited by 7 publications

(3 citation statements)

References 84 publications

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Section: Antibacterial Activitymentioning

confidence: 81%

“…100% against both bacteria. Compared to the reported Ti-PDA/BP/ZnO, TiO2/MoS2/PDA/RGD, CpTi-SiO2-3Cu, and Ti-Co15 coatings, the good antibacterial result of PDA/Cu-Ov-Co3O4 was speculated to be attributed to the ROS, localized hyperthermia, and metal ion release effects [8,[40][41][42]. Basically, in order to kill E. coli, the direct heating temperature should not be lower than 50 °C; otherwise, there is no substantial threat to the viability of E. coli.…”

Section: Antibacterial Activitymentioning

confidence: 88%

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Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Qi,

Yu,

Liu

et al. 2024

Materials

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Medical titanium-based (Ti-based) implants in the human body are prone to infection by pathogenic bacteria, leading to implantation failure. Constructing antibacterial nanocoatings on Ti-based implants is one of the most effective strategies to solve bacterial contamination. However, single antibacterial function was not sufficient to efficiently kill bacteria, and it is necessary to develop multifunctional antibacterial methods. This study modifies medical Ti foils with Cu-doped Co3O4 rich in oxygen vacancies, and improves their biocompatibility by polydopamine (PDA/Cu-Ov-Co3O4). Under near-infrared (NIR) irradiation, nanocoatings can generate •OH and 1O2 due to Cu+ Fenton-like activity and a photodynamic effect of Cu-Ov-Co3O4, and the total reactive oxygen species (ROS) content inside bacteria significantly increases, causing oxidative stress of bacteria. Further experiments prove that the photothermal process enhances the bacterial membrane permeability, allowing the invasion of ROS and metal ions, as well as the protein leakage. Moreover, PDA/Cu-Ov-Co3O4 can downregulate ATP levels and further reduce bacterial metabolic activity after irradiation. This coating exhibits sterilization ability against both Escherichia coli and Staphylococcus aureus with an antibacterial rate of ca. 100%, significantly higher than that of bare medical Ti foils (ca. 0%). Therefore, multifunctional synergistic antibacterial nanocoating will be a promising strategy for preventing bacterial contamination on medical Ti-based implants.

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Section: Antibacterial Activitymentioning

confidence: 81%

Section: Antibacterial Activitymentioning

confidence: 88%

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Qi,

Yu,

Liu

et al. 2024

Materials

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“…The biological activity of Ti can be rapidly improved by applying an active coating on its Ti using various spraying techniques, including plasma spraying and sputtering. , An electron-enriched bactericidal effect can be achieved by spraying graphene nanomaterials (GNS) in a TiO 2 matrix . However, the GNS coatings usually lack uniformity in terms of composition, thickness, and surface morphology, producing thick films (50–200 μm) that tend to undergo fracture and delamination .…”

Section: Static Modification Strategymentioning

confidence: 99%

The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

Cui,

Zhao,

Bai

et al. 2024

ACS Biomater. Sci. Eng.

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Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these biomaterials possess stable properties and good biocompatibility, the high elastic modulus and low surface activity of Ti implants have often been associated with infection, inflammation, and poor osteogenesis. Therefore, there is an urgent need to modify the surface of Ti implants, where changes in surface morphology or coatings loading can confer specific functions to help them adapt to the osseointegration formation phase and resist bacterial infection. This can further ensure a healthy microenvironment for bone regeneration as well as the promotion of immunomodulation, angiogenesis, and osteogenesis. Therefore, in this review, we evaluated various functional Ti implants after surface modification, both in terms of static modifications and dynamic response strategies, mainly focusing on the synergistic effects of antimicrobial activities and functionalized osteogenic. Finally, the current challenges and future perspectives are summarized to provide innovative and effective solutions for osseointegration and bone defect repair.

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Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants

Xu,

Lin,

Xiao

et al. 2024

Adv Healthcare Materials

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Enabling minimally invasive and precise control of liquid release in dental implants is crucial for therapeutic functions such as delivering antibiotics to prevent biofilm formation, infusing stem cells to promote osseointegration, and administering other biomedicines. However, achieving controllable liquid cargo release in dental implants remains challenging due to the lack of wireless and miniaturized fluidic control mechanisms. Here wireless miniature pumps and valves that allow remote activation of liquid cargo delivery in dental implants, actuated and controlled by external magnetic fields (<65 mT), are reported. A magnet‐screw mechanism in a fluidic channel to function as a piston pump, alongside a flexible magnetic valve designed to open and close the fluidic channel, is proposed. The mechanisms are showcased by storing and releasing of liquid up to 52 µL in a dental implant. The liquid cargos are delivered directly to the implant–bone interface, a region traditionally difficult to access. On‐demand liquid delivery is further showed by a metal implant inside both dental phantoms and porcine jawbones. The mechanisms are promising for controllable liquid release after implant placement with minimal invasion, paving the way for implantable devices that enable long‐term and targeted delivery of therapeutic agents in various bioengineering applications.

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Enhanced antibacterial activity and superior biocompatibility of cobalt-deposited titanium discs for possible use in implant dentistry

Cited by 7 publications

References 84 publications

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

Polydopamine-Coated Copper-Doped Co3O4 Nanosheets Rich in Oxygen Vacancy on Titanium and Multimodal Synergistic Antibacterial Study

The Effect of Antibacterial-Osteogenic Surface Modification on the Osseointegration of Titanium Implants: A Static and Dynamic Strategy

Wirelessly Actuated Microfluidic Pump and Valve for Controlled Liquid Delivery in Dental Implants

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