Enhanced antibacterial nanocomposite mats by coaxial electrospinning of polycaprolactone fibers loaded with Zn-based nanoparticles

Prado-Prone, Gina; Silva-Bermúdez, Phaedra; Almaguer‐Flores, Argelia; García-Macedo, Jorge A.; García, Victor I.; Rodil, Sandra E.; Ibarra, Clemente; Velasquillo, Cristina

doi:10.1016/j.nano.2018.04.005

Cited by 36 publications

(20 citation statements)

References 30 publications

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“…For example, tetracycline hydrochloride encapsulated into electrospun core–shell nanofibers showed a sustained release, and exhibited great antibacterial capability, as shown in Escherichia coli growth-inhibiting tests [28]. ZnO and Zn acetate nanoparticles were embedded in polycaprolactone coaxial-fiber and uniaxial-fiber matrices to develop potential antibacterial nanocomposite wound dressings [29]. In order to guide tissue regeneration in an infectious environment, coaxial electrospinning was firstly conducted to fabricate dual drug-loaded fiber mats with a core/shell structure.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

et al. 2019

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Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic the natural extracellular matrix (ECM). Tissue engineering aims to fabricate functional biomaterials for the repairment and regeneration of defective tissue. In addition to the structural simulation for accelerating the repair process and achieving a high-quality regeneration, the combination of biomaterials and bioactive molecules is required for an ideal tissue-engineering scaffold. Due to the diversity in materials and method selection for electrospinning, a great flexibility in drug delivery systems can be achieved. Various drugs including antibiotic agents, vitamins, peptides, and proteins can be incorporated into electrospun scaffolds using different electrospinning techniques and drug-loading methods. This is a review of recent research on electrospun nanofibrous scaffolds for tissue-engineering applications, the development of preparation methods, and the delivery of various bioactive molecules. These studies are based on the fabrication of electrospun biomaterials for the repair of blood vessels, nerve tissues, cartilage, bone defects, and the treatment of aneurysms and skin wounds, as well as their applications related to oral mucosa and dental fields. In these studies, due to the optimal selection of drugs and loading methods based on electrospinning, in vitro and in vivo experiments demonstrated that these scaffolds exhibited desirable effects for the repair and treatment of damaged tissue and, thus, have excellent potential for clinical application.

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Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

et al. 2019

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“…Membranes for water decontamination should possess high porosity and wide distribution of pore size to provide sufficient surface area to interact with the contaminant, regardless its nature. [36][37][38][39][40] Polymers with high chemical resistance and excellent mechanical performance are preferred for the manufacture of purification devices with longer lifetime. Moreover, the addition of inorganic nanoparticles has been conducted for the development of composite polymer membranes foreseen for the elimination of a wide range of contaminants.…”

Section: Introductionmentioning

confidence: 99%

Core–sheath nanofibrous membranes based on poly(acrylonitrile‐butadiene‐styrene), polyacrylonitrile, and zinc oxide nanoparticles for photoreduction of Cr(VI) ions in aqueous solutions

Castro‐Ruíz¹,

Rodríguez-Tobías²,

Abraham

et al. 2019

J of Applied Polymer Sci

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This investigation addresses the design of a series of poly(acrylonitrile-butadiene-styrene)/polyacrylonitrile-zinc oxide(ABS/PAN-ZnO) membranes by coaxial electrospinning. In the first instance, an optimization of ABS and PAN electrospinning was performed, thus establishing suitable compositional and processing parameters for obtaining homogenous fibers. Then, coaxial electrospinning of ABS and PAN solutions containing different amount of ZnO nanoparticles was carried out. The coaxial morphology of the nanofibers and ZnO distribution/dispersion were studied by the combination of several techniques such as scanning electron microscopy, X-ray energy dispersive analysis, contact angle, and thermogravimetric analysis. The performance of the obtained membranes for chromium (VI) ions removal from aqueous solutions was assessed by photoreduction using ultraviolet-visible spectroscopy. Electrospun mats composed of ABS (core)/PAN (sheath) embedded with 30 wt % of ZnO nanoparticles exhibited the highest chromium photoreduction (about 80%), suggesting the potential use of these membranes as filters for water purification.

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“…Antibacterial tests were carried on against S. aureus and E. coli, observing a major activity against gram-positive (S. aureus) bacteria. The effects of UVA light exposure (prior to bacteria inoculation) on mats were studied too, resulting in an even more effective antibacterial activity [146].…”

Section: Multiaxial Electrospinningmentioning

confidence: 99%

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

2021

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Surgical meshes have been employed in the management of a variety of pathological conditions including hernia, pelvic floor dysfunctions, periodontal guided bone regeneration, wound healing and more recently for breast plastic surgery after mastectomy. These common pathologies affect a wide portion of the worldwide population; therefore, an effective and enhanced treatment is crucial to ameliorate patients’ living conditions both from medical and aesthetic points of view. At present, non-absorbable synthetic polymers are the most widely used class of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor dysfunctions and guided bone regeneration, with polypropylene and poly tetrafluoroethylene being the most common. Biological prostheses, such as surgical grafts, have been employed mainly for breast plastic surgery and wound healing applications. Despite the advantages of mesh implants to the treatment of these conditions, there are still many drawbacks, mainly related to the arising of a huge number of post-operative complications, among which infections are the most common. Developing a mesh that could appropriately integrate with the native tissue, promote its healing and constructive remodelling, is the key aim of ongoing research in the area of surgical mesh implants. To this end, the adoption of new biomaterials including absorbable and natural polymers, the use of drugs and advanced manufacturing technologies, such as 3D printing and electrospinning, are under investigation to address the previously mentioned challenges and improve the outcomes of future clinical practice. The aim of this work is to review the key advantages and disadvantages related to the use of surgical meshes, the main issues characterizing each clinical procedure and the future directions in terms of both novel manufacturing technologies and latest regulatory considerations. Graphic abstract

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Enhanced antibacterial nanocomposite mats by coaxial electrospinning of polycaprolactone fibers loaded with Zn-based nanoparticles

Cited by 36 publications

References 30 publications

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Core–sheath nanofibrous membranes based on poly(acrylonitrile‐butadiene‐styrene), polyacrylonitrile, and zinc oxide nanoparticles for photoreduction of Cr(VI) ions in aqueous solutions

Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design and emerging manufacturing technologies

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