2022
DOI: 10.1016/j.xcrm.2022.100764
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Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection

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Cited by 23 publications
(28 citation statements)
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“…In line with previous studies, the third vaccination, as well as Omicron breakthrough infection, boosted the SARS-CoV-2 antibody response, resulting in higher IgG titers and SARS-CoV-2–neutralizing activity ( 7 10 , 18 , 30 ). The SARS-CoV-2–reactive B cell response was highly polyclonal at all investigated time points, but in contrast to previous reports ( 31 , 32 ), we detected only limited maturation of memory B cells and no significant increase in breadth of newly detected clones after the third vaccination.…”
Section: Discussionsupporting
confidence: 88%
“…In line with previous studies, the third vaccination, as well as Omicron breakthrough infection, boosted the SARS-CoV-2 antibody response, resulting in higher IgG titers and SARS-CoV-2–neutralizing activity ( 7 10 , 18 , 30 ). The SARS-CoV-2–reactive B cell response was highly polyclonal at all investigated time points, but in contrast to previous reports ( 31 , 32 ), we detected only limited maturation of memory B cells and no significant increase in breadth of newly detected clones after the third vaccination.…”
Section: Discussionsupporting
confidence: 88%
“…Several studies have reported the effects of different number of vaccinations on neutralization in BA.1 and BA.2 breakthrough infection. 16 , 18 , 19 , 30 To investigate whether the number of vaccinations impacts the neutralizing potency after BA.5 infection, we compared the levels of binding and neutralizing antibodies in serum samples from infected adult individuals who have received two (2 doses of IV, n = 25) or three (3 doses of IV, n = 39) doses of inactivated virus vaccines (Fig. 3a–c ).…”
Section: Resultsmentioning
confidence: 99%
“…This observation is particularly striking considering all human patients had previously received up to date COVID-19 vaccines, including an original prime and boost regimen plus an additional booster of either Moderna or Pfizer COVID-19 mRNA vaccines prior contracting COVID-19 only 8-12 weeks before sample collection. Previous reports have demonstrated that patients with such hybrid immunity have superior neutralizing antibodies than patients who had been infected but not previously vaccinated [48][49][50][51][52] . These data show great promise for further investigation of the TLRa-SNPs adjuvant technology in larger animal models.…”
Section: Discussionmentioning
confidence: 99%