Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

Lu, Kun Ying; Jheng, Pei Ru; Long, Lu; Rethi, Lekshmi; Mi, Fwu Long; Chuang, Er Yuan

doi:10.1016/j.ijbiomac.2020.10.091

Cited by 50 publications

(22 citation statements)

References 70 publications

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“…Among multiple methods developed as an alternative way to fight bacterial infections in response to antibiotic resistance, PTT occupies a prominent place. [191][192][193] When photo-responsive agents are activated with a convenient NIR laser, the surface plasmon band leads to the conversion of electromagnetic radiation to heat. The resulting heat can reach temperatures able to destroy bacterial cells.…”

Section: Photothermal Therapy Overview Of Photothermal Therapymentioning

confidence: 99%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

128

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Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, the metal ion release and photodynamic and photothermal effects of nanomaterials were demonstrated to have substantial efficiency in eliminating resistance and surges of bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, and optical features have been utilized to control metal ion release, generate reactive oxygen species, and produce heat for antibacterial applications. The superior characteristics of nanomaterials present an opportunity to explore and enhance their antibacterial activities leading to clinical applications. In this review, we comprehensively list three different antibacterial mechanisms of metal ion release, photodynamic therapy, and photothermal therapy based on nanomaterials. These three different antibacterial mechanisms are divided into their respective subgroups in accordance with recent achievements, showcasing prospective challenges and opportunities in clinical, environmental, and related fields.

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Section: Photothermal Therapy Overview Of Photothermal Therapymentioning

confidence: 99%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

128

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“…Photothermal therapy is a treatment that utilizes photothermal agents activated by light irradiation. The absorbed light energy is transformed into heat by photothermal agents for therapeutic purposes [23][24][25]. Photothermal therapy was reported to induce no bacterial resistance, and therefore, it is effective Nanomaterials 2021, 11, 3064 2 of 12 against superbugs [26].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

et al. 2021

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Light-responsive nanocomposites have become increasingly attractive in the biomedical field for antibacterial applications. Visible-light-activated metallic molybdenum disulfide nanosheets (1T-MoS2 NSs) and plasmonic gold nanorods (AuNRs) with absorption at a wavelength of 808 nm were synthesized. AuNR nanocomposites decorated onto 1T-MoS2 NSs (MoS2@AuNRs) were successfully prepared by electrostatic adsorption for phototherapy applications. Based on the photothermal effect, the solution temperature of the MoS2@AuNR nanocomposites increased from 25 to 66.7 °C after 808 nm near-infrared (NIR) laser irradiation for 10 min. For the photodynamic effect, the MoS2@AuNR nanocomposites generated reactive oxygen species (ROS) under visible light irradiation. Photothermal therapy and photodynamic therapy of MoS2@AuNRs were confirmed against E. coli by agar plate counts. Most importantly, the combination of photothermal therapy and photodynamic therapy from the MoS2@AuNR nanocomposites revealed higher antibacterial activity than photothermal or photodynamic therapy alone. The light-activated MoS2@AuNR nanocomposites exhibited a remarkable synergistic effect of photothermal therapy and photodynamic therapy, which provides an alternative approach to fight bacterial infections.

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“…Furthermore, photodynamic and photothermal therapy based on nanoparticles have been suggested as novel anti-cancer treatments [119,120]. Moreover, the anti-cancer effects and molecular mechanisms of photothermal therapy using photosensitive polypyrrole nanoparticles and fucoidan have been reported in 2020 [121]. Thus, the development of new treatment strategies using fucoidan-based anti-cancer agents is expected in the near future.…”

Section: Future Directionsmentioning

confidence: 99%

“…Thus, the development of new treatment strategies using fucoidan-based anti-cancer agents is expected in the near future. On the other hand, regulation of ROS and VEGF are associated with the pharmacological activity of photothermal therapy using photosensitive polypyrrole nanoparticles and fucoidan [121]. It is well known that both ROS and VEGF play crucial roles in tumor growth, progression, and survival in cancer patients [52,[122][123][124].…”

Section: Future Directionsmentioning

confidence: 99%

Present Status, Limitations and Future Directions of Treatment Strategies Using Fucoidan-Based Therapies in Bladder Cancer

Miyata

Matsuo

Ohba

et al. 2020

Cancers

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Bladder cancer (BC) is a common urological cancer, with poor prognosis for advanced/metastatic stages. Various intensive treatments, including radical cystectomy, chemotherapy, immune therapy, and radiotherapy are commonly used for these patients. However, these treatments often cause complications and adverse events. Therefore, researchers are exploring the efficacy of natural product-based treatment strategies in BC patients. Fucoidan, derived from marine brown algae, is recognized as a multi-functional and safe substrate, and has been reported to have anti-cancer effects in various types of malignancies. Additionally, in vivo and in vitro studies have reported the protective effects of fucoidan against cancer-related cachexia and chemotherapeutic agent-induced adverse events. In this review, we have introduced the anti-cancer effects of fucoidan extracts in BC and highlighted its molecular mechanisms. We have also shown the anti-cancer effects of fucoidan therapy with conventional chemotherapeutic agents and new treatment strategies using fucoidan-based nanoparticles in various malignancies. Moreover, apart from the improvement of anti-cancer effects by fucoidan, its protective effects against cancer-related disorders and cisplatin-induced toxicities have been introduced. However, the available information is insufficient to conclude the clinical usefulness of fucoidan-based treatments in BC patients. Therefore, we have indicated the aspects that need to be considered regarding fucoidan-based treatments and future directions for the treatment of BC.

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Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles

Cited by 50 publications

References 70 publications

Emerging Trends in Nanomaterials for Antibacterial Applications

Emerging Trends in Nanomaterials for Antibacterial Applications

Gold Nanorod-Decorated Metallic MoS2 Nanosheets for Synergistic Photothermal and Photodynamic Antibacterial Therapy

Present Status, Limitations and Future Directions of Treatment Strategies Using Fucoidan-Based Therapies in Bladder Cancer

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