Enhanced antimicrobial activities of 1-alkyl-3-methyl imidazolium ionic liquids based on silver or copper containing anions

Gilmore, Brendan; Andrews, Gavin; Borberly, Gabor; Earle, Martyn J.; Gîlea, Manuela A.; Gorman, Seán; Lowry, Andrew; McLaughlin, Martin; Seddon, Kenneth R.

doi:10.1039/c3nj40759d

Cited by 46 publications

(39 citation statements)

References 33 publications

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“…Ionic liquids could have superior penetration abilities and could aid in a prolonged retention into wood, increasing its service life. Anions containing transitional metals (such as tetrachlorocuprate or tetrachloroferrate) are already available in conjunction with alkylpyridinium or alkylimidazolium cations [ 125 ]. Ionic liquids could also serve as a good synthesis and dispersion medium for nanoparticles and could be used as carrier for the impregnation of wood, potentiating the antifungal effect of the metal nanoparticles [ 126 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Ionic Liquids as Antifungal Agents for Wood Preservation

Croitoru

Roată

2020

Molecules

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Ionic liquids represent a class of highly versatile organic compounds used extensively in the last decade for lignocellulose biomass fractionation and dissolution, as well as property modifiers for wood materials. This review is dedicated to the use of ionic liquids as antifungal agents for wood preservation. Wood preservation against fungal attack represents a relatively new domain of application for ionic liquids, emerging in the late 1990s. Comparing to other application domains of ionic liquids, this particular one has been relatively little researched. Ionic liquids may be promising as wood preservatives due to their ability to swell wood, which translates into better penetration ability and fixation into the bulk of the wood material than other conventional antifungal agents, avoiding leaching over time. The antifungal character of ionic liquids depends on the nature of their alkyl-substituted cation, on the size and position of their substituents, and of their anion. It pertains to a large variety of wood-colonizing fungi, both Basidiomycetes and Fungiimperfecti.

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Section: Future Perspectivesmentioning

confidence: 99%

Ionic Liquids as Antifungal Agents for Wood Preservation

Croitoru

Roată

2020

Molecules

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“…This indicates that the electrospinning from dry acetone also removes most of the remaining water from the samples. As stated in the introduction, copper-containing ILs have antimicrobial potential [34], and nickel-based electrospun ionogels have been successfully used in hydrogen production from NaBH 4 solution [60,61]. Ionogel fiber mats such as those presented here could therefore also be interesting for NaBH 4 decomposition or sterile filtration.…”

Section: Mixtures Of Pmma and [Bmim] 2 [Cuclmentioning

confidence: 99%

“…This is consistent with previous work [69,70] and indicates that the IL also influences the spinning process as such. The results thus show that it is possible to fabricate ionogel fiber mats that could be attractive for, for example, sterile filtration by virtue of their high porosity and -at least by IL standards -relatively cheap antibacterial IL [34] contained within the fibers. 4 ] in dry acetone are only homogeneous (one phase) up to a total content of PMMA and IL combined of 70 g L −1 .…”

Section: Introductionmentioning

confidence: 97%

“…In one example of bringing metal-based ILs into the realm of applications, Gilmore et al have shown that both the structure of the cation and the chemistry of the metal ion (silver vs. copper) affect the overall toxicity and antibacterial activity of Cu-and Ag-based imidazolium ILs [34]. As a tuneable toxicity in principle enables a tuneable antibiotic activity, this report sug-gests that metal-containing ILs could be attractive for the fabrication of sterile or antiseptic materials.…”

Section: Introductionmentioning

confidence: 99%

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Ionogel Fiber Mats: Functional Materials via Electrospinning of PMMA and the Ionic Liquid Bis(1-butyl-3-methyl-imidazolium) Tetrachloridocuprate(II), [Bmim]₂[CuCl₄]

Bagdahn

Taubert

2013

Zeitschrift Für Naturforschung B

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Ionogel fiber mats were made by electrospinning poly(methylmethacrylate) (PMMA) and the ionic liquid (IL) bis(1-butyl-3-methyl-imidazolium) tetrachloridocuprate(II), [Bmim] 2 [CuCl 4 ], from acetone. The morphology of the electrospun ionogels strongly depends on the spinning parameters. Dense and uniform fiber mats were only obtained at concentrations of 60 to 70 g L −1 of polymer and IL mass combined. Lower concentrations led to a low number of poorly defined fibers. High voltages of 20 to 25 kV led to well-defined and uniform fibers; voltages between 15 and 20 kV again led to less uniform and less dense fibers. At 10 kV and lower, no spinning could be induced. Finally, PMMA fibers electrospun without IL show a less well-defined morphology combining fibers and oblong droplets indicating that the IL has a beneficial effect on the electrospinning process. The resulting materials are prototypes for new functional materials, for example in sterile filtration.

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“…However, the introduction of hydroxyethyl groups in the IL side chain causes a reduction of the antimicrobial activity [30,31]. Although the anion effect has been generally less studied in comparison to the cation core [24], the selection of metal-based anions has been proved to significantly impact the microbial viabilities, which can be linked to the capacity of these compounds to produce reactive oxygen species and protein denaturation, which can destabilize several cellular pathways [32]. ILs have demonstrated their clinical value as antimicrobial agents through the ability to form antibacterial films towards a broad range of pathogens, to enhance the antibacterial activity of several antibiotics when synthesized in an IL-based platform, such as an ampicillin-based IL, and to avoid the development of biofilms of multidrug-resistant species [33,34].…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

Vieira¹,

Oliveira²,

Araújo³

et al. 2021

Sustainable Chemistry

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The task-specific design of ionic liquids (ILs) has emerged in several industrial and pharmaceutical applications. The family of ILs with fluorine tags equal to or longer than four carbon atoms, the fluorinated ionic liquids (FILs), combine the best properties of ILs with the ones of perfluorinated compounds, and are being designed for several specific purposes. In the pharmaceutical field, there is an urgency to search for novel antibacterial agents to overcome problems associated to antimicrobial resistances. Then, the main purpose of this work is to evaluate the environmental impact and the ability of FILs to be used as antibacterial agents against Pseudomonas stutzeri bacteria. Beyond its rare pathogenicity, these bacteria are also used as a bioremediation agent to treat several contamination sites. Then, it is important to determine which FILs have antibacterial properties, and which do not impact the bacterial growth. The biocompatibility of FILs was also evaluated through their hemolytic activity and represent a step forward the application of FILs in pharmaceutical applications. The results proved that high concentrations of FILs can have a reduced ecotoxicity and a high biocompatibility. [C8C1Im][CF3SO3] was identified as the most promising compound to be used as an antibacterial agent since it prevents the growth of bacteria at concentrations compatible with the red blood cells’ viability.

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Enhanced antimicrobial activities of 1-alkyl-3-methyl imidazolium ionic liquids based on silver or copper containing anions

Cited by 46 publications

References 33 publications

Ionic Liquids as Antifungal Agents for Wood Preservation

Ionic Liquids as Antifungal Agents for Wood Preservation

Ionogel Fiber Mats: Functional Materials via Electrospinning of PMMA and the Ionic Liquid Bis(1-butyl-3-methyl-imidazolium) Tetrachloridocuprate(II), [Bmim]₂[CuCl₄]

Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

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Enhanced antimicrobial activities of 1-alkyl-3-methyl imidazolium ionic liquids based on silver or copper containing anions

Cited by 46 publications

References 33 publications

Ionic Liquids as Antifungal Agents for Wood Preservation

Ionic Liquids as Antifungal Agents for Wood Preservation

Ionogel Fiber Mats: Functional Materials via Electrospinning of PMMA and the Ionic Liquid Bis(1-butyl-3-methyl-imidazolium) Tetrachloridocuprate(II), [Bmim]2[CuCl4]

Ecotoxicity and Hemolytic Activity of Fluorinated Ionic Liquids

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Resources

About

Ionogel Fiber Mats: Functional Materials via Electrospinning of PMMA and the Ionic Liquid Bis(1-butyl-3-methyl-imidazolium) Tetrachloridocuprate(II), [Bmim]₂[CuCl₄]