Enhanced antimicrobial properties of bioactive glass using strontium and silver oxide nanocomposites

Abstract

Bioactive glass has a wide range of biomedical applications. It has attracted immense interest due to its unique ability to bond with a bone through ion exchange in simulated body fluid (SBF) when implanted inside the body. This study concerns sol-gel synthesis of a new bioactive glass composition: 55SiO 2 -40CaO-(5-x) SrO-xAg 2 O doped with different mol% of silver as an antibacterial agent, i.e. 0%, 2% and 4% AgSr(0), AgSr(2) & AgSr(3), respectively. This method is a widely used in the preparation of glass ceramics because of its lowtemperature. The effect of introducing strontium in addition to silver as an antimicrobial agent into the bioglass matrix was studied. Structural studies were conducted using various techniques including Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Field emission scanning electron microscope (FE-SEM) and High-resolution transmission electron microscopy (HR-TEM). Bioactivity was investigated by in-vitro synthesis involving immersion of the samples in SBF for different time intervals. The XRD, FTIR and FE-SEM results confirmed the formation of a hydroxylapatite layer on the surface of the finally prepared bioglass materials. An antimicrobial study revealed that the prepared bioactive glass showed a significant effect on two bacteria E. coli and S. aureus. ARTICLE HISTORY

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

“…Previously, antibacterial test results have shown that the strontium substituted 58S BG could exhibit the antibacterial effect against methicillin-resistant staphylococcus aureus (MRSA) bacteria which are resistant to methicillin and other associated antibiotics of the penicillin class. Bacterial activities ,including growth and reproduction, cell wall synthesis, cell metabolism as well as chromosomal replication can be inhibited by the release of Sr 2+ ions, as well [42,[44][45][46].…”

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

“…Previously, antibacterial test results have shown that the strontium substituted 58S BG could exhibit the antibacterial effect against methicillin-resistant staphylococcus aureus (MRSA) bacteria which are resistant to methicillin and other associated antibiotics of the penicillin class. Bacterial activities ,including growth and reproduction, cell wall synthesis, cell metabolism as well as chromosomal replication can be inhibited by the release of Sr 2+ ions, as well [52,[54][55][56].…”

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

“…The release of ionic compounds in the medium can enhance the pH level of the medium and environment osmotic pressure. These factors are effective in the antibacterial activity of BGs . The chemical composition of BGs and the dissolution condition of their environments effect the antibacterial influence of them …”

“…Compounds containing Cu, such as CuSO 4 and Cu(OH) 2 , are known as inorganic materials . Normally, the electrical charge of bacterial cell wall is negative which is because of the presence of carboxylic groups in the lipoproteins at the bacterial surface . Because of the opposite charge between bacteria and released Cu ions from the BGs, bioactivity and adhesion occurred between them, and by demolishing the cell wall of bacteria, bacterial death takes place…”

“…The incorporation of elemental additives such as alkali, alkaline earth, transition and posttransition metals enhances BGs performance and introduces osteoconductivity, angiogenicity and antibacterial properties . Magnesium (Mg) is the fourth most abundant metal cation in the human body and the second most common intracellular cation and approximately 50%–60% of Mg total content is stored in the skeleton .…”