Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release

Tuna, Bilge Güvenç; Atalay, Pinar Buket; Kuku, Gamze; Acar, Elif Esma; Kara, Hanife; Yilmaz, M. Deniz; Özalp, Veli Cengiz

doi:10.1039/c9ra07974b

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…Fe 3 O 4 @SiO 2 particles were functionalized with epoxy groups via silanization reactions by (3-glycidyloxypropyl)triethoxysilane as described previously. 16 The 5′-amine-labelled I27 aptamer sequences were conjugated to the surface of Fe 3 O 4 @SiO 2 particles by incubating in carbonate–bicarbonate buffer.…”

Section: Methodsmentioning

confidence: 99%

Surface plasmon resonance aptasensor for soluble ICAM-1 protein in blood samples

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Doğan

Kavruk

et al. 2022

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Section: Methodsmentioning

confidence: 99%

Surface plasmon resonance aptasensor for soluble ICAM-1 protein in blood samples

Dursun

Doğan

Kavruk

et al. 2022

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“…The synthesized benzimidazole hybrids (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) that displayed root mean square deviation (RMSD) less than 2 Å and lowest ΔE was selected to evaluate the binding affinity of the tested compounds (Table 2). The BE (À 8.03 to À 8.66 Kcal/mol) for compounds 8-16 is higher than Erlotinib, which exhibited BE more than compounds 7 and 17 (À 7.60 and À 7.65 Kcal/ mol), respectively.…”

Section: Molecular Dockingmentioning

confidence: 99%

“…For example, albendazole, veliparib, bendamustine, nezartinib and benomyle contains benzimidazole pharmacophore that acts through various mechanisms. [16][17][18][19][20][21][22] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…However, in case of compound 16 and 17, additional aliphatic methylene protons resonated in the range 1.86-3.68 ppm. The structure of all the final compounds (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) was also supported by 13 CNMR spectrum which showed appearance of two signals in the aliphatic region at δ 45.35-47.46 ppm (À NÀ CH2À ), and 33.77-36.57 ppm (SÀ CH 2 À ) and downfield signal at δ 169.39-171.77 ppm (C=O) confirmed the presence of the carbonyl group in the structure. The structure formation was also supported by mass spectrometry which displayed desired ion peak for the molecules.…”

Section: Introductionmentioning

confidence: 99%

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Benzimidazole‐1,3,4‐Oxadiazole Hybrids: Synthesis, Anticancer Evaluation, Docking and DFT Studies

et al. 2022

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In the present work, new benzimidazole based 1,3,4-oxadiazole linked thioacetamide conjugates have been synthesized and evaluated for antiproliferative activity. Formation of all the target molecules were elucidated by NMR ( 1 H & 13 C), FTIR, mass spectrometry and other techniques. The compounds displayed significant to moderate cytotoxicity towards MCF-7, HepG2 and HCT-116 cancerous cell lines. Among all the compounds, compound 11, 12 and 13 showed promising cytotoxicity with IC 50 2.39-10.98 μM, 4.57-16.35 μM and 3.10-15.58 μM towards MCF-7, HepG2 and HCT-116, respectively. Also, compound 11, 12 and 13 inhibited EGFR with IC 50 0.91-2.1 μM and exhibited high binding energy of À 8.34, À 8.06 & À 8.08 Kcal/mol, respectively against EGFR protein in docking study. The DFT study was also found to be consistent with the anticancer results of these newly synthesized compounds. It can be concluded that these 1,3,4-oxadiazole based benzimidazole derivatives possess promising anticancer properties and could be used as anticancer leads. Results and DiscussionChemistry ortho-Phenylenediamine 1 was the main raw material for the preparation of all the final compound 7-17. All the intermedi-[a] S.

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“…This carrier was tested against human cervical adenocarcinoma cells. The results showed that MSNs with aptamer gate exhibited a 3.3-fold increase of toxicity to the target cells compare to pure carbendazim [ 148 ].…”

Section: Msns As Smart Drug Delivery Agentmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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Enhanced antitumor activity of carbendazim on HeLa cervical cancer cells by aptamer mediated controlled release

Abstract: Carbendazim doped and aptamer-gate functionalized mesoporous silica nanoparticles targeted nucleolin on HeLa cell surface for specific delivery. This delivery system improved antitumor activity of carbendazim by about 3 folds increase of EC50 values.

Cited by 10 publications

References 29 publications

Surface plasmon resonance aptasensor for soluble ICAM-1 protein in blood samples

Surface plasmon resonance aptasensor for soluble ICAM-1 protein in blood samples

Benzimidazole‐1,3,4‐Oxadiazole Hybrids: Synthesis, Anticancer Evaluation, Docking and DFT Studies

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

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