Enhanced Antitumor Efficacy with Combined Administration of Astragalus and Pterostilbene for Melanoma

Huang, Xinyan; Zhang, Songzhao; Wang, Wenxi

doi:10.7314/apjcp.2014.15.3.1163

Cited by 7 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…136 The combination of pterostilbene and astragalus enhances apoptosis and inhibits the cell growth of melanoma in SK-MEL-2 cells and in SK-MEL-2 bearing mice. 137 Pterostilbene combined with curcumin demonstrated significant potency to decrease LOX-mediated activity, thus suppressing HCC cell metastasis induced by long-term ethanol exposure. 138 Taken together, these findings suggest that pterostilbene cotreatment with other phytochemicals brings synergy benefits or targets multiple molecular mechanisms to boost the efficacy of anticancer treatments.…”

Section: T H Imentioning

confidence: 95%

“…Singh et al showed that a combination of pterostilbene and lupeol was more effective in reducing tumorigenesis and ROS generation in B[a]P-induced mouse skin carcinogenesis . The combination of pterostilbene and astragalus enhances apoptosis and inhibits the cell growth of melanoma in SK-MEL-2 cells and in SK-MEL-2 bearing mice . Pterostilbene combined with curcumin demonstrated significant potency to decrease LOX-mediated activity, thus suppressing HCC cell metastasis induced by long-term ethanol exposure .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene

Lin

Leland²,

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

Supplementation with natural compounds found in fruits and vegetables has long been associated with a reduced risk of several types of cancer. Pterostilbene is a natural stilbenoid and a dimethylated analogue of resveratrol which is found primarily in blueberries. Pterostilbene exhibits a range of pharmacological properties, particularly anti-inflammatory and anticancer effects. Due to two methoxy groups in its skeleton, pterostilbene is more lipophilic than resveratrol and thus possesses higher intestinal permeability and cellular uptake and enhanced stability. Moreover, pterostilbene exhibits less toxicity and fewer adverse effects, providing it with superior potential in cancer chemoprevention and chemotherapy applications. Numerous research studies have demonstrated that pterostilbene possesses detoxification activities, mediating the anti-inflammation response, regulating the cell cycle, augmenting apoptosis, enhancing autophagy, and inhibiting tumor angiogenesis, invasion, and metastasis by modulating signal transduction pathways which block multiple stages of carcinogenesis. In this review, we illustrate that pterostilbene is a natural compound having bioavailability. The extensive metabolism of pterostilbene will be discussed. We also summarize recent research on pterostilbene’s anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management.

show abstract

Section: T H Imentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene

Lin

Leland²,

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…In April 2012, the patient consulted a naturopathic doctor (Shainhouse) and began therapy with the following oral natural anti-cancer agents: Active hexose correlated compound or AHCC (mushroom extract)[ 29 ], dandelion root[ 30 ], curcumin[ 31 ], and astragalus root[ 32 ]. Parenteral therapy was also started, which consisted of intravenous vitamin C twice weekly[ 33 ] and subcutaneous European mistletoe extract[ 34 ].…”

Section: Case Reportmentioning

confidence: 99%

Long-term stabilization of metastatic melanoma with sodium dichloroacetate

Khan¹,

Andrews²,

Shainhouse³

et al. 2017

WJCO

View full text Add to dashboard Cite

Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007, based on a publication from Bonnet et al demonstrating that DCA can induce apoptosis (programmed cell death) in human breast, lung and brain cancer cells. Classically, the response of cancer to a medical therapy in human research is measured by Response Evaluation Criterial for Solid Tumours definitions, which define “response” by the degree of tumour reduction, or tumour disappearance on imaging, however disease stabilization is also a beneficial clinical outcome. It has been shown that DCA can function as a cytostatic agent in vitro and in vivo, without causing apoptosis. A case of a 32-year-old male is presented in which DCA therapy, with no concurrent conventional therapy, resulted in regression and stabilization of recurrent metastatic melanoma for over 4 years’ duration, with trivial side effects. This case demonstrates that DCA can be used to reduce disease volume and maintain long-term stability in patients with advanced melanoma.

show abstract

“…These effects arise by binding of a protein called Bax to Bcl-2 (Haldar et al, 1998). Bcl-2 and Bax are two important proteins and play role in mitochondrial-mediated pathway (Huang et al, 2014). The ratio between Bcl-2 and Bax expression level determines whether cells respond to an apoptotic signal (Liu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Effects of Hypobaric Conditions on Apoptosis Signalling Pathways in HeLa Cells

Arıcan

Khalilia²,

Serbes³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Nowadays increasing effectiveness in cancer therapy and investigation of formation of new strategies that enhance antiproliferative activity against target organs has become a subject of interest. Although the molecular mechanisms of apoptosis can not be fully explained, it is known that cell suicide program existing in their memory genetically is activated by pathophysiological conditions and events such as oxidative stress. Low pressure (hypobaric) conditions that create hypoxia promote apoptosis by inhibiting cell cycling. In this study, determination of the effects of fractional hypobaric applications at different times on HeLa cells at cellular and molecular levels were targeted. Experiments were carried out under hypobaric conditions (35.2 kPa) in a specially designed hypobaric cabin including 2% O 2 and 98% N. Application of fractional hypobaric conditions was repeated two times for 3 hours with an interval of 24 hours. At the end of the implementation period cells were allowed to incubate for 24 hours for activation of repair mechanisms. Cell kinetic parameters such as growth rate (MTT) and apoptotic index were used in determination of the effect of hypobaric conditions on HeLa cells. Also in our study expression levels of the Bcl-2 gene family that have regulatory roles in apoptosis were determined by the RT-PCR technique to evaluate molecular mechanisms. The results showed that antiproliferative effect of hypobaric conditions on HeLa cells started three hours from the time of application and increased depending on the period of exposure. While there was a significant decrease in growth rate values, there was a significant increase in apoptotic index values (p<0.01). Also molecular studies showed that hypobaric conditions caused a significant increase in expression level of proapoptotic gene Bax and significant decrease in antiapoptotic Bfl-1. Consequently fractional application of hypobaric conditions on HeLa cell cultures increased both antiproliferative and apoptotic effects and these effects were triggered by the Bax gene.

show abstract

Enhanced Antitumor Efficacy with Combined Administration of Astragalus and Pterostilbene for Melanoma

Cited by 7 publications

References 34 publications

Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene

Occurrence, Bioavailability, Anti-inflammatory, and Anticancer Effects of Pterostilbene

Long-term stabilization of metastatic melanoma with sodium dichloroacetate

Effects of Hypobaric Conditions on Apoptosis Signalling Pathways in HeLa Cells

Contact Info

Product

Resources

About