Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells

Detoxification of Aflatoxin B1 by Phytochemicals in Agriculture and Food Science

“…31,33 AFB 1 has toxic effects on the germ cells and accessory cells of livestock such as bovines, sheep, and goats, thus seriously endangering the development of gametes and fertilized eggs and causing great economic losses. 30,32,34,35 Furthermore, previous study reported the presence of AFB 1 in fetal cord blood following maternal exposure to AFB 1 , which might significantly affect fetal development. 36 Due to the vigorous metabolic activity of the liver, most of AFB 1 is oxidized to AFBO in the liver and then covalently binds to the seventh nitrogen atom of DNA guanine to form AFB 1 −N 7 -guanine (AFB 1 −N 7 -Gua) adduct, which leads to the blockage of DNA replication, and causes a variety of gene mutations and exerts genotoxicity.…”

“…Moreover, AFB 1 inhibits antioxidant protein expression, induces cell cycle arrest and DNA damage, leading to the mitochondria-dependent apoptosis of various nerve cells . The reproductive toxic effects of AFB 1 were observed in different animal studies through in vitro maturation (IVM), in vitro fertilization (IVF), measurement of physiological indicators including ROS and GSH, detection of DNA damage markers, and multiple omics analyses. − In addition to inducing increased oxidative stress and DNA damage, AFB 1 reduces the expression of cell cycle-related genes in porcine and mouse oocytes, resulting in cell cycle abnormalities. , AFB 1 has toxic effects on the germ cells and accessory cells of livestock such as bovines, sheep, and goats, thus seriously endangering the development of gametes and fertilized eggs and causing great economic losses. ,,, Furthermore, previous study reported the presence of AFB 1 in fetal cord blood following maternal exposure to AFB 1 , which might significantly affect fetal development …”