Enhanced Bio-Adhesion and Sustained Delivery of Clotrimazole Encapsulated Solid Lipid Nanoparticles Loaded in Hyaluronic Acid Gel as Anti- Fungal Therapy

Senthil, V.; Harsha, Merikanapalli V.; Moteriya, Pooja; Paranjothy, Murali; Kumar, Rohitesh

doi:10.9734/bjpr/2017/34063

Cited by 1 publication

(1 citation statement)

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“…DSC was employed to study the material purity, thermal properties (heat changesmelting and recrystallization), and compatibility attributes of the drug and granules. The slight variation between this DSC scan and other reports on CLOT 6,54,55 could be due to differences in instrument scan rate settings or the actual state of CLOT used in these studies. Nonetheless, an endothermic melting peak for CLOT was designated.…”

Section: Discussionmentioning

confidence: 78%

Lipid Nanoemulsion-Based Liquisolid Compact Tablets for Oral Delivery of Clotrimazole: Fabrication Strategies, Characterizations, Antimycotic and Toxicological Evaluations

Umeyor

Ezechukwu²,

Okafor³

et al. 2022

Bulletin of Pharmaceutical Sciences. Assiut

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This work aims to fabricate liquisolid compact tablets incorporating clotrimazole (CLOT)loaded lipid nanoemulsions (LNE) for oral treatment of systemic fungal infections.Nanoemulsion was characterized for droplet size, rendered into free-flowing granules and compressed into liquisolid compact tablets, and evaluated using pharmacopoeial and nonpharmacopoeial methods. In-vitro and in vivo antifungal, stability and toxicological tests of the tablets were evaluated. . Liquisolid tablets were stable, non-toxic, had uniform weight (341.4 ± 1.2 -346.7 ± 0.8 mg), drug content uniformity (85.2 ± 0.1 -99.8 ± 0.2 %), and had excellent disintegration (2.96 ± 0.8 -5.88 ± 1.3 min), and controlled release property. In-vitro and in vivo antifungal evaluations revealed improved antimycotic activity of CLOT. The results highlight that CLOT-LNE liquisolid compact tablets is a promising carrier system with improved oral utility for the treatment of systemic fungal infections.

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Section: Discussionmentioning

confidence: 78%