Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material

Wan, Li; Zhang, Tianpeng; Ye, Yanghuan; Zhang, Qizhou; Wu, Baojian

doi:10.1016/j.ijpharm.2015.10.011

Cited by 35 publications

(31 citation statements)

References 38 publications

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“…For instance, tripterine was encapsulated in lipid derived from an edible plant, in other words, broccoli by solvent diffusion method and enhanced oral bioavailability was achieved in comparison to Precirol ATO 5-based lipid nanoparticles and drug suspension suggesting the applicability of plant-based lipids [58]. Also, siberian pine seed oil and fish oil have been employed as liquid oils in formulating stable NLCs [59,60].…”

Section: Fabrication Of Nlcsmentioning

confidence: 99%

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Poonia¹,

Kharb

Lather³

et al. 2016

Future Sci. OA

151

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Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therapeutic functionality and prolonged release from these carrier systems thus providing improved pharmacokinetic parameters. The present review provides an overview of noteworthy studies reporting impending benefits of NLCs in oral delivery and highlights recent advancements for developing engineered NLCs either by conjugating polymers over their surface or modifying their charge to overcome the mucosal barrier of GI tract for active transport across intestinal membrane.

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Section: Fabrication Of Nlcsmentioning

confidence: 99%

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Poonia¹,

Kharb

Lather³

et al. 2016

Future Sci. OA

151

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“…28 Meanwhile, lipolysis of lipid nanoparticles and reconstruction into smaller mixed micelles can also facilitate the payload transport across the intestinal epithelia, thus increasing the oral absorption. 22,29 These advantages render NLCs rather suitable for oral drug delivery. Our engineered SeNLCs were developed from NLCs that possess better physiological stability and sustained drug release capacity.…”

mentioning

confidence: 99%

Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

Yin¹,

Hou²,

Yin³

et al. 2017

IJN

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Diabetes mellitus is an incurable metabolic disorder that seriously threatens human health. At present, there is no effective medication available to defeat it. This work intended to develop selenium-coated nanostructured lipid carriers (SeNLCs) for enhancing the oral bioavailability and the curative effect of berberine, an antidiabetic phytomedicine. Berberine-loaded SeNLCs (BB-SeNLCs) were prepared by hot-melt dispersion/homogenization procedure followed by in situ reduction. BB-SeNLCs were characterized by particle size, morphology, entrapment efficiency (EE) and in vitro release. Pharmacokinetics of berberine solution, berberine-loaded NLCs (BB-NLCs) and BB-SeNLCs were studied in Sprague Dawley rats administered by oral gavage. The prepared BB-SeNLCs were around 160 nm in particle size with an EE of 90%. In addition, BB-SeNLCs exhibited a better sustained release of berberine compared to the plain NLCs. After oral administration, BB-SeNLCs greatly enhanced the oral bioavailability of berberine, which was approximately 6.63 times as much as that of berberine solution. The hypoglycemic effect of BB-SeNLCs was also significantly superior to that of BB-NLCs and berberine solution. It turned out that sustained drug release and good intestinal absorption, plus the synergy of selenium, were basically responsible for enhanced oral bioavailability and hypoglycemic effect. Our findings show that SeNLCs are promising nanocarriers for oral delivery of berberine to strengthen the antidiabetic action.

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“…The EE of RES-GNPs was determined by the centrifugal ultrafiltration technique with a minor modification. 23 The unentrapped RES was first removed by centrifugation at 15,000 rpm for 5 min. Then, the upper layer of RES-GNPs was pipetted and placed in a centrifugal filter device (Amicon ® Ultra-0.5, MWCO 5,000; Merck Millipore).…”

Section: Characterization Of Res-gnpsmentioning

confidence: 99%

Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity

Siu

Lin

et al. 2018

IJN

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BackgroundResveratrol (RES) is a natural anti-inflammatory and antioxidant compound with poor water solubility and oral bioavailability. The present study takes the advantages of nanocarriers combined with a ligand (galactose) anchoring to orally deliver RES in an attempt to improve its bioavailability and pharmacological activity.MethodsRES-loaded galactosylated nanoparticles (RES-GNPs) were prepared by solvent diffusion technique using poly(lactic-co-glycolic acid), synthesized N-oleoyl-d-galactosamine and Tween 80. RES-GNPs were characterized by particle size, morphology, entrapment efficiency (EE) and in vitro release. Oral bioavailability and in vitro anti-inflammatory activity were investigated in rats and lipopolysaccharides-induced RAW 264.7 cells, respectively.ResultsThe resulting RES-GNPs were 108.4 nm around in particle size with a polydispersity index of 0.217. Furthermore, RES-GNPs possessed a high EE and a slow drug release in water. After oral administration, RES-GNPs significantly enhanced the oral bioavailability of RES, up to 335.7% relative to RES suspensions. In situ single-pass intestinal perfusion and cellular uptake experiments showed that GNPs could improve the intestinal permeability and transcellular transport of RES. Moreover, the anti-inflammatory efficacy of RES-GNPs in RAW 264.7 cells model was superior to free RES and RES-GNPs.ConclusionThe results indicate that RES-GNPs can effectively promote the intestinal absorption of RES and strengthen its bioactivity, which may be a promising system for the treatment of inflammatory diseases.

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Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material

Cited by 35 publications

References 38 publications

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Nanostructured Lipid Carriers: Versatile Oral Delivery Vehicle

Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect

Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity

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