2021
DOI: 10.3390/pr9050730
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Enhanced Biomechanical Properties of Polyvinyl Alcohol-Based Hybrid Scaffolds for Cartilage Tissue Engineering

Abstract: Articular cartilage damage is a primary feature of osteoarthritis and other inflammatory joint diseases (i.e., rheumatoid arthritis). Repairing articular cartilage is highly challenging due to its avascular/aneural nature and low cellularity. To induce functional neocartilage formation, the tissue substitute must have mechanical properties which can adapt well to the loading conditions of the joint. Among the various biomaterials which may function as cartilage replacements, polyvinyl alcohol (PVA) hydrogels s… Show more

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Cited by 34 publications
(20 citation statements)
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References 90 publications
(333 reference statements)
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“…However, slow biodegradation and poor cell adhesion properties have limited the use of PVA hydrogels for clinical cartilage tissue regeneration applications. Therefore, to enhance the bio-applicability of PVA hydrogels, hybrid PVA-based hydrogel composites combining PVA with PEG, PCL, poly(lactic-co-glycolic acid) (PLGA), alginate, chitosan, and bioglass have been extensively investigated [ 104 ]. In a similar context, Meng et al fabricated a bioinspired PVA/graphene oxide-hydroxyapatite (GO-HA)nanocomposite hydrogel by an extrusion 3D printing method.…”
Section: Hydrogel Composition: Materials Used To Prepare Hydrogelsmentioning
confidence: 99%
“…However, slow biodegradation and poor cell adhesion properties have limited the use of PVA hydrogels for clinical cartilage tissue regeneration applications. Therefore, to enhance the bio-applicability of PVA hydrogels, hybrid PVA-based hydrogel composites combining PVA with PEG, PCL, poly(lactic-co-glycolic acid) (PLGA), alginate, chitosan, and bioglass have been extensively investigated [ 104 ]. In a similar context, Meng et al fabricated a bioinspired PVA/graphene oxide-hydroxyapatite (GO-HA)nanocomposite hydrogel by an extrusion 3D printing method.…”
Section: Hydrogel Composition: Materials Used To Prepare Hydrogelsmentioning
confidence: 99%
“…Thus, the main focus and key to the future of cartilage regeneration deals with the mechanical properties of the materials; a high resistance will promote mechanical stability of a joint, and high-water content will maintain a lubricious surface. In addition, bioactivity is also required to sustain cell proliferation and migration; the materials that make up the scaffold should retain a capacity for biodegradation and a possibility to remodel as new cartilage, considering that for cartilage to totally regenerate, it will require a longer time period, unlike other tissues [ 67 ].…”
Section: Applications Of Scaffolds That Deliver Oxygen For Cartilage ...mentioning
confidence: 99%
“…Both synthetic and natural polymers are frequently used to develop hydrogels for tissue engineering [55][56][57][58][59]. Hydrogels are composed of hydrophilic polymeric chains crosslinked through either covalent or non-covalent bonds.…”
Section: Biomaterials For Tissue Engineeringmentioning
confidence: 99%