Enhanced Bone Defect Repair by Polymeric Substitute Fillers of MultiArm Polyethylene Glycol‐Crosslinked Hyaluronic Acid Hydrogels

Yuan, Jishan; Maturavongsadit, Panita; Metavarayuth, Kamolrat; Luckanagul, Jittima Amie; Wang, Qian

doi:10.1002/mabi.201900021

Cited by 12 publications

(14 citation statements)

References 39 publications

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“…Although many studies have shown that HA holds great potential for promoting osteogenesis in vitro ( Koca et al, 2019 ; Yuan et al, 2019 ; Jang et al, 2020 ), recent findings have demonstrated that HA serves more as an osteoinductive scaffold since application of HA alone failed to induce sufficient bone regeneration as compared to treatments involving graft materials ( Sindel et al, 2017 ; Diker et al, 2018 ). Similarly, the presence of HA alone in the implant osteotomy also failed to yield improved osseointegration ( Yazan et al, 2019 ).…”

Section: Proteoglycans Modulate the Chondrogenic Differentiation Of Mesenchymal Stem Cellsmentioning

confidence: 99%

“…This suggested that HA alone was insufficient for bone regeneration, therefore the combination of HA and other material such as collagen and hydroxyapatite may be essential for improving bone regeneration in vivo . Yuan et al (2019) developed a bio-degradable bone graft material consisting of multiarm polyethylene glycol crosslinked with HA hydrogels, which brought a significant improvement to ALP activity and calcium mineralization in vitro . The multiarm PEG-HA hydrogels also facilitated healing of the cranial bone defects of rats.…”

Section: Proteoglycans Modulate the Chondrogenic Differentiation Of Mesenchymal Stem Cellsmentioning

confidence: 99%

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Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Chen

Sun

You

et al. 2021

Front. Cell Dev. Biol.

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Stem cells maintain a subtle balance between self-renewal and differentiation under the regulatory network supported by both intracellular and extracellular components. Proteoglycans are large glycoproteins present abundantly on the cell surface and in the extracellular matrix where they play pivotal roles in facilitating signaling transduction and maintaining stem cell homeostasis. In this review, we outline distinct proteoglycans profiles and their functions in the regulation of stem cell homeostasis, as well as recent progress and prospects of utilizing proteoglycans/glycosaminoglycans as a novel glycomics carrier or bio-active molecules in bone regeneration.

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Section: Proteoglycans Modulate the Chondrogenic Differentiation Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Section: Proteoglycans Modulate the Chondrogenic Differentiation Of Mesenchymal Stem Cellsmentioning

confidence: 99%

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Chen

Sun

You

et al. 2021

Front. Cell Dev. Biol.

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“…Because the cells are not able to adhere directly to it, recent studies have used combinations of natural compounds such as hyaluronic acid (HA) or gelatin, thus optimizing their characteristics (Sharma et al, 2015;D'souza and Shegokar, 2016). However, synthetic biomaterials have a limited capacity to induce endogenous repair responses, so their majority use has been for prostheses and implants (Koupaei et al, 2015;Yuan et al, 2019).…”

Section: Composition Syntheticmentioning

confidence: 99%

Neurorestoration Approach by Biomaterials in Ischemic Stroke

et al. 2020

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BACKGROUND Stroke is one of the most important health problems worldwide. Ischemic stroke (IS) constitutes 85-90% of the casuistry among the types of stroke and is the leading cause of disability in people over 65 years of age worldwide (Ghuman and Modo, 2016). Due to the epidemiological importance and the big socioeconomic expenditure involved, it is priority advance in its prevention, control, and treatment (Kalaria et al., 2016; Benjamin et al., 2017). The ischemic injury is caused by an interruption of blood supply in one or more cerebral blood vessels triggering a set of dynamic processes that affect all brain cells and extracellular matrix (ECM) deteriorating the "glioneurovascular niche" (Boisserand et al., 2016). The pathophysiology of IS lies in the restriction or reduction of the supply of oxygen, glucose, and nutrients in the affected brain area. The ischemic cascade begins while there is arterial obstruction causing accidental cell death of core cells damaging tissue irreversibly. This process is accompanied by events of glutamate excitotoxicity, oxidative stress, and neuroinflammation, which affect the homeostatic functioning of the neurons in the affected tissue. The combination of all of them induces permanent brain lesions (Taylor et al., 2008; Thundyil and Lim, 2015; Thornton et al., 2017). However, there are regions near the nucleus or ischemic penumbra (IP) that have had access to a collateral blood circulation, being able to partially counteract the energy deficit (Fisher and Albers, 2013; Gavaret et al., 2019).

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“…Finally, the results showed that the HA-TA-PL hydrogel induced the formation and deposition of cartilage-like extracellular matrix. Also, to enhance the osteogenesis of MSCs, Jishan Yuan et al used hydrogels based on the multiarm polyethylene glycol (PEG) cross-linked with hyaluronic acid (HA) (PEG-HA hydrogels) [98]. Synthesis of three types of the HA-based hydrogels through Michael addition reaction between a thiol group of crosslinkers and methacrylate groups on HA is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

“…Republished with permission of ref. [98], Yuan J, Maturavongsadit P, Metavarayuth K, Luckanagul JA, Wang Q. Enhanced Bone Defect Repair by Polymeric Substitute Fillers of MultiArm Polyethylene Glycol-Crosslinked Hyaluronic Acid Hydrogels.…”

Section: Introductionmentioning

confidence: 99%

An overview of advanced biocompatible and biomimetic materials for creation of replacement structures in the musculoskeletal systems: focusing on cartilage tissue engineering

et al. 2019

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Tissue engineering, as an interdisciplinary approach, is seeking to create tissues with optimal performance for clinical applications. Various factors, including cells, biomaterials, cell or tissue culture conditions and signaling molecules such as growth factors, play a vital role in the engineering of tissues. In vivo microenvironment of cells imposes complex and specific stimuli on the cells, and has a direct effect on cellular behavior, including proliferation, differentiation and extracellular matrix (ECM) assembly. Therefore, to create appropriate tissues, the conditions of the natural environment around the cells should be well imitated. Therefore, researchers are trying to develop biomimetic scaffolds that can produce appropriate cellular responses. To achieve this, we need to know enough about biomimetic materials. Scaffolds made of biomaterials in musculoskeletal tissue engineering should also be multifunctional in order to be able to function better in mechanical properties, cell signaling and cell adhesion. Multiple combinations of different biomaterials are used to improve above-mentioned properties of various biomaterials and to better imitate the natural features of musculoskeletal tissue in the culture medium. These improvements ultimately lead to the creation of replacement structures in the musculoskeletal system, which are closer to natural tissues in terms of appearance and function. The present review article is focused on biocompatible and biomimetic materials, which are used in musculoskeletal tissue engineering, in particular, cartilage tissue engineering.

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Enhanced Bone Defect Repair by Polymeric Substitute Fillers of MultiArm Polyethylene Glycol‐Crosslinked Hyaluronic Acid Hydrogels

Cited by 12 publications

References 39 publications

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Proteoglycans and Glycosaminoglycans in Stem Cell Homeostasis and Bone Tissue Regeneration

Neurorestoration Approach by Biomaterials in Ischemic Stroke

An overview of advanced biocompatible and biomimetic materials for creation of replacement structures in the musculoskeletal systems: focusing on cartilage tissue engineering

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