Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

Lim, Ho-Kyung; Kwon, Ik Jae; On, Sung-Woon; Hong, Seong Ahn; Yang, Byoung-Eun; Kim, Soung Min; Lee, Jong Ho; Byun, Soo-Hwan

doi:10.3390/ijms222111485

Cited by 4 publications

(2 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histomorphometry analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in both cases. 259 The Mg-substituted biphasic calcium phosphate (BCMP) scaffold fabricated by robocasting is made calcium deficient by subjecting it to hydrolysis. The calcium nodule formation and ALP activity induce osteoinduction and osteoconduction, making BCMP scaffolds ideal for bone regeneration.…”

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 99%

See 1 more Smart Citation

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

show abstract

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 99%

“…In a similar study, the osteogenic capability of pure BCP and collagen-added BCP scaffolds were tested with different concentrations of rhBMP-2. Histomorphometry analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in both cases …”

Section: Biocompatibility and Bioresorbability Studies On Additive Ma...mentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

Local drug delivery challenges and innovations in spinal neurosurgery

Karavasili,

Young,

Francis

et al. 2024

Journal of Controlled Release

View full text Add to dashboard Cite

Research progress of gene therapy combined with tissue engineering to promote bone regeneration

Chu,

Xiong,

et al. 2024

APL Bioengineering

View full text Add to dashboard Cite

Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is a common clinical need. Meanwhile, many preclinical data have demonstrated that gene and cell therapies combined with optimal scaffold biomaterials could be used to solve these tough issues. Bone tissue engineering, an interdisciplinary field combining cells, biomaterials, and molecules with stimulatory capability, provides promising alternatives to enhance bone regeneration. To deliver and localize growth factors and associated intracellular signaling components into the defect site, gene therapy strategies combined with bioengineering could achieve a uniform distribution and sustained release to ensure mesenchymal stem cell osteogenesis. In this review, we will describe the process and cell molecular changes during normal fracture healing, followed by the advantages and disadvantages of various gene therapy vectors combined with bone tissue engineering. The growth factors and other bioactive peptides in bone regeneration will be particularly discussed. Finally, gene-activated biomaterials for bone regeneration will be illustrated through a description of characteristics and synthetic methods.

show abstract

Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

Cited by 4 publications

References 53 publications

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Local drug delivery challenges and innovations in spinal neurosurgery

Research progress of gene therapy combined with tissue engineering to promote bone regeneration

Contact Info

Product

Resources

About