Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

Tian, Xin; Lin, Xiaoning; Feng, Wei; Huang, Zhichun; Wang, Peng; Ren, Lei; Diao, Yong

doi:10.2147/ijn.s16570

Cited by 71 publications

(29 citation statements)

References 36 publications

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“…First, by exploiting the preferential absorption of ApoE on some types of NPs when in serum. This feature has been described for PBCA NPs coated with polysorbate 80, indeed displaying the ability to cross the BBB in vivo in animal models [ 83 – 85 ] and for PEGylated PHDCA NPs, able to penetrate into brain endothelial cells in vitro [ 86 ].…”

Section: How Nps Can Cross the Bbbmentioning

confidence: 79%

Nanoparticles for Brain Drug Delivery

2013

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The central nervous system, one of the most delicate microenvironments of the body, is protected by the blood-brain barrier (BBB) regulating its homeostasis. BBB is a highly complex structure that tightly regulates the movement of ions of a limited number of small molecules and of an even more restricted number of macromolecules from the blood to the brain, protecting it from injuries and diseases. However, the BBB also significantly precludes the delivery of drugs to the brain, thus, preventing the therapy of a number of neurological disorders. As a consequence, several strategies are currently being sought after to enhance the delivery of drugs across the BBB. Within this review, the recently born strategy of brain drug delivery based on the use of nanoparticles, multifunctional drug delivery systems with size in the order of one-billionth of meters, is described. The review also includes a brief description of the structural and physiological features of the barrier and of the most utilized nanoparticles for medical use. Finally, the potential neurotoxicity of nanoparticles is discussed, and future technological approaches are described. The strong efforts to allow the translation from preclinical to concrete clinical applications are worth the economic investments.

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Section: How Nps Can Cross the Bbbmentioning

confidence: 79%

Nanoparticles for Brain Drug Delivery

2013

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“…Interestingly, non-ionic surfactants could promote the adsorption of ApoE onto the surface of NPs 66 . For example, polysorbate 80, an FDA-approved injectable surfactant, could adsorb ApoE in serum when it was conjugated onto NPs, and polysorbate 80-coated NPs have been evaluated as a brain targeting delivery system by many groups 67 , 68 , 69 , 70 . Martins et al 69 evaluated the brain targeting efficiency of polysorbates 60 and 80 for enhancing brain targeting of NPs.…”

Section: Strategies To Overcome the Bbbmentioning

confidence: 99%

Progress and perspectives on targeting nanoparticles for brain drug delivery

Gao

2016

Acta Pharmaceutica Sinica B

427

233

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Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier (BBTB), and nose-to-brain barrier. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed.

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“…Polysorbate 80 (PS 80), an excipient and surfactant, has widely been used in the clinic to stabilize aqueous formulations of medications for parenteral administration 21 or used as an emulsifier in manufacturing 22 due to its amphiphilicity and low toxicity. More interestingly, PS 80 was explored to modify the surface of nanocarriers for the delivery of a number of CNS drugs into the brain of animals with varying success 23 - 25 . These strategies involve serum ApoE adsorption onto the particles, thus causing interacttions with low-density lipoprotein receptor-related protein 1 (LRP1) followed by transcytosis across the BBB through vascular endothelial cells 25 .…”

Section: Introductionmentioning

confidence: 99%

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

et al. 2018

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Rationale: Treatment for Parkinson's disease (PD) is challenged by the presence of the blood-brain barrier (BBB) that significantly limits the effective drug concentration in a patient's brain for therapeutic response throughout various stages of PD. Curcumin holds the potential for α-synuclein clearance to treat PD; however, its applications are still limited due to its low bioavailability and poor permeability through the BBB in a free form.Methods: Herein, this paper fabricated curcumin-loaded polysorbate 80-modified cerasome (CPC) nanoparticles (NPs) with a mean diameter of ~110 nm for enhancing the localized curcumin delivery into the targeted brain nuclei via effective BBB opening in combination with ultrasound-targeted microbubble destruction (UTMD).Results: The liposomal nanohybrid cerasome exhibited superior stability towards PS 80 surfactant solubilization and longer circulation lifetime (t1/2 = 6.22 h), much longer than free curcumin (t1/2 = 0.76 h). The permeation was found to be 1.7-fold higher than that of CPC treatment only at 6 h after the systemic administration of CPC NPs. Notably, motor behaviors, dopamine (DA) level and tyrosine hydroxylase (TH) expression all returned to normal, thanks to α-synuclein (AS) removal mediated by efficient curcumin delivery to the striatum. Most importantly, the animal experiment demonstrated that the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice had notably improved behavior disorder and dopamine depletion during two-week post-observation after treatment with CPC NPs (15 mg curcumin/kg) coupled with UTMD.Conclusion: This novel CPC-UTMD formulation approach could be an effective, safe and amenable choice with higher therapeutic relevance and fewer unwanted complications than conventional chemotherapeutics delivery systems for PD treatment in the near future.

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Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles

Cited by 71 publications

References 36 publications

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery

Progress and perspectives on targeting nanoparticles for brain drug delivery

Localized delivery of curcumin into brain with polysorbate 80-modified cerasomes by ultrasound-targeted microbubble destruction for improved Parkinson's disease therapy

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