Enhanced Cellular Internalization: A Bactericidal Mechanism More Relative to Biogenic Nanoparticles than Chemical Counterparts

Kumari, Madhuree; Shukla, Saumya; Pandey, Shipra; Giri, Ved Prakash; Bhatia, Ashok Kumar; Tripathi, Tusha; Kakkar, Poonam; Nautiyal, Chandra Shekhar; Mishra, Aradhana

doi:10.1021/acsami.6b15473

Cited by 67 publications

(61 citation statements)

References 59 publications

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“…Based on the results obtained, BSNP was able to penetrate bacterial membrane more easily than CSNP, which demonstrates the enhancement of antimicrobial efficiency of silver nanoparticles by reducing and modifying their surface with antimicrobial metabolites of cell free filtrate of Trichoderma viride (MTCC 5661) in comparison to citrate stabilized silver nanoparticles. So, this study affirms that biologically synthesized silver nanoparticles coated with antimicrobial metabolites of T. viride were more effective than their chemical counterpart in killing of pathogenic bacteria [131].…”

Section: Toxicity and Challengessupporting

confidence: 70%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Ficai³

et al. 2020

Preprint

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This paper aims to review the challenges, toxicity, and routes of synthesis and usage of silver nanoparticles in different applications but also highlighting their sustainability from both medical and environmental issues. Regarding their toxicity, it is known that silver nanoparticles can destroy over 650 microorganisms comparing with antibiotics. Supplementary, will be presented in a comparative manner some conventional synthesis routes (physical and chemical methods) and green synthesis routes using plant extracts. The approach using plant extracts have various advantages comparing with physical, chemical and microbial synthesis methods because there is no need to use chemicals, wasteful purifications and high energy requirements. The paper presents an overview on “green nanotechnology” focused on using either biological micro-organisms or plant extracts as an alternative to the classical chemical and physical methods. An important issue discussed in the paper is an overview of the synthesis routes of silver nanoparticles, some expected applications of silver based active agents and their toxicity and challenges that must be overcome. Also, it needs to focus our attention on the dismissal of silver nanoparticles into the environment and especially in water systems, fact which suggests that this issue must be fully understood and applied the law.

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Section: Toxicity and Challengessupporting

confidence: 70%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Ficai³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Toxicity and Challengessupporting

confidence: 70%

Toward Synthesis-derived Applications of Silver Nanoparticles

Spoială¹,

Ficai²,

Craciun³

et al. 2020

Preprint

View full text Add to dashboard Cite

This paper aims to review the challenges, toxicity, and routes of synthesis and usage of silver nanoparticles in different medical applications but also highlighting their sustainability from both medical and environmental issues. Regarding their toxicity, it is known that silver nanoparticles can destroy over 650 microorganisms comparing with antibiotics. Supplementary, will be presented in a comparative manner some conventional synthesis routes (physical and chemical methods) and green synthesis routes using plant extracts. The approach using plant extracts have various advantages comparing with physical, chemical and microbial synthesis methods because there is no need to use chemicals, wasteful purifications and high energy requirements. The main focus in “green nanotechnology” was to use either biological micro-organisms or plant extracts which are an alternative to the classical chemical and physical methods. An important issue that is discussed in the paper is the potential toxicity of silver nanoparticles that may have on human health or on the environment, which powerfully indicates that, the usage and removal of silver nanoparticles must be carefully examined. Also, it needs to focus our attention on the dismissal of silver nanoparticles into the environment and especially in water systems, fact which suggests that this issue must be fully understood and apply accordingly the law.

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“…Earlier, Noolvi et al (2014) reported cytotoxic and antimicrobial activity of novel azetidine-2-one. Decane, dodecene, undecene, octane, and cetene obtained in the extract form a major part of essential oils, known to show antimicrobial and antioxidative properties (Chouhan et al, 2017;Kumari et al, 2017). Dedecane skeleton containing compounds isolated from marine isolate Penicillium bilaiae MA-267 have shown antifungal properties against plant pathogens (Meng et al, 2014).…”

Section: Analysis Of Bioactive Compounds In Aspergillus Unguis (Ag12mentioning

confidence: 99%

Endophytic Fungi of Marine Alga From Konkan Coast, India—A Rich Source of Bioactive Material

et al. 2020

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Endophytes are an unexploited source of pharmacologically relevant compounds owing to their species richness and diversity. In this study, a total of 26 endophytic fungi were isolated and identified from 10 marine algal samples collected from the Konkan coast, Goa, India. Eighteen of the fungal isolates belonged to phylum Ascomycota while one belonged to phylum Basidiomycota based on ITS sequencing. Further, the genus Aspergillus sp. was the most common and abundant endophyte found in the sampled algal species. A significant antibacterial activity against five pathogenic bacteria was exhibited by the extracts of fungal isolates AG1.1, AG1.1 (G) and VG2.6 (agar diffusion assay). The extracts of fungal endophytes VB1.1, PG1.2 and VG2.6 demonstrated good antioxidant activity (DPPH scavenging assay). Further, cytotoxicity of all the endophytic extracts on human cancer cell lines was determined by MTT and resazurin assay. The crude extract of Aspergillus unguis (AG 1.2) showed the highest cytotoxic potential on cervical cancer (HeLa), breast cancer (MCF-7), lung cancer (A549), and skin cancer (A431) cell lines in a concentration dependent manner. Moreover, Gas Chromatography-Mass Spectroscopy analysis of the extract of A. unguis (AG 1.2) confirmed the presence of several bioactive metabolites including azelaic acid, azetidine, and furopyrans. The extract of A. unguis (AG 1.2) demonstrated G1 phase cell cycle arrest, reactive oxygen species (ROS)-dependent MMP loss and apoptosis-dependent cell death in A431 cells. The algae-derived fungal endophytes of Konkan coast are a rich source of novel pharmaceutically active compounds as indicated by this work.

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Enhanced Cellular Internalization: A Bactericidal Mechanism More Relative to Biogenic Nanoparticles than Chemical Counterparts

Cited by 67 publications

References 59 publications

Toward Synthesis-derived Applications of Silver Nanoparticles

Toward Synthesis-derived Applications of Silver Nanoparticles

Toward Synthesis-derived Applications of Silver Nanoparticles

Endophytic Fungi of Marine Alga From Konkan Coast, India—A Rich Source of Bioactive Material

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