“…[16][17][18] Currently, modern synthetic methods and surface science modeling tools make it possible to design and construct nanostructures with the desired features. A variety of nanomaterials such as nanoparticles, 19,20 nanowires, 21 nanorods, 22 carbon nanotubes, 23,24 and graphenes 25 provide favorable microenvironments for stabilizing the bioactivity of biomolecules, large surface areas for improving the contact of biomolecules with the substrate in a small total volume, and excellent electrical conductivity for enhancing the electron transfer and improving the detection sensitivity. In particular, nanoporous Au (NPA) is an excellent candidate for electrochemical sensor prototypes due to its unique physicochemical properties, bicontinuous porous structure, high surface-to-volume ratios, excellent inplane conductivity and biocompatibility.…”