Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

Ma, Ping’an; Xiao, Haihua; Chang, Yu; Liu, Jianhua; Cheng, Ziyong; Song, Hang; Zhang, Xinyang; Li, Chunxia; Wang, Jinqiang; Gu, Zhen; Lin, Jun

doi:10.1021/acs.nanolett.6b04269

Cited by 587 publications

(361 citation statements)

References 58 publications

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“…A more direct method is to develop iron‐containing nanoparticles that can deliver and release iron into cancer cell. Most previous studies used solid iron‐based nanocrystals, such as iron oxide nanoparticles and FePt nanoparticles as the iron source to trigger Fenton chemistry in tumor . The amount of Fe 2+ /Fe 3+ ions released from these nanoparticles is influenced by pH value and reductive environment .…”

Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

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Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.

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Section: Ferroptosis Inducers For Cancer Therapymentioning

confidence: 99%

Recent Progress in Ferroptosis Inducers for Cancer Therapy

et al. 2019

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“…In addition, unlike cisplatin, the nanoparticles are internalized into cells via endocytosis, which contributes to the reversal of the cell’s resistance to cisplatin. [47] …”

Section: Nanomaterials For Ferroptosis-based Cancer Therapymentioning

confidence: 99%

Emerging Strategies of Cancer Therapy Based on Ferroptosis

et al. 2018

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Ferroptosis, a new form of regulated cell death that is iron- and reactive oxygen species dependent, has attracted much attention in the research communities of biochemistry, oncology, and especially material sciences. Since the first demonstration in 2012, a series of strategies have been developed to induce ferroptosis of cancer cells, including the use of nanomaterials, clinical drugs, experimental compounds, and genes. A plethora of research work has outlined the blueprint of ferroptosis as a new option for cancer therapy. However, the published ferroptosis-related reviews have mainly focused on the mechanisms and pathways of ferroptosis, which motivated this contribution to bridge the gap between biological significance and material design. Therefore, it is timely to summarize the previous efforts on the emerging strategies for inducing ferroptosis and shed light on future directions for using such a tool to fight against cancer. Here, the current strategies of cancer therapy based on ferroptosis will be elaborated, the design considerations and the advantages and limitations are highlighted, and finally a future perspective on this emerging field is given.

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“…Ma et al first used cisplatin to activate NOX for catalyzing dissolved O 2 into O 2 •− , which can be further converted into H 2 O 2 by cellular SOD (Equation ), finally favoring IONP‐triggered Fenton reaction . Based on the intrinsic catalytic chemistry of glucose oxidase (GOx), which can catalyze the production of H 2 O 2 from intratumoral glucose (Equation ), we recently constructed GOx and Fe 3 O 4 nanoparticles coloaded dendritic MSNs (DMSNs) for improved CDT efficacy ( Figure ) .…”

Section: Nanocatalytic Medicine For Cancer Therapiesmentioning

confidence: 99%

Nanocatalytic Medicine

2019

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Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such as nanozymes, photocatalysts, and electrocatalysts, have been applied in vivo to initiate catalytic reactions and modulate biological microenvironments for generating therapeutic effects. The rapid growth of research in biomedical applications of nanocatalysts has led to the concept of “nanocatalytic medicine,” which is expected to promote the further advance of such a subdiscipline in nanomedicine. The high efficiency and selectivity of catalysis that chemists strived to achieve in the past century can be ingeniously translated into high efficacy and mitigated side effects in theranostics by using “nanocatalytic medicine” to steer catalytic reactions for optimized therapeutic outcomes. Here, the rationale behind the construction of nanocatalytic medicine is eludicated based on the essential reaction factors of catalytic reactions (catalysts, energy input, and reactant). Recent advances in this burgeoning field are then comprehensively presented and the mechanisms by which catalytic nanosystems are conferred with theranostic functions are discussed in detail. It is believed that such an emerging catalytic therapeutic modality will play a more important role in the field of nanomedicine.

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Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

Cited by 587 publications

References 58 publications

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Emerging Strategies of Cancer Therapy Based on Ferroptosis

Nanocatalytic Medicine

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