2024
DOI: 10.3389/fbioe.2024.1364975
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Enhanced cisplatin chemotherapy sensitivity by self-assembled nanoparticles with Olaparib

Tao Zhang,
Xiao Li,
Liang Wu
et al.

Abstract: Cisplatin (CDDP) is widely used as one kind of chemotherapy drugs in cancer treatment. It functions by interacting with DNA, leading to the DNA damage and subsequent cellular apoptosis. However, the presence of intracellular PARP1 diminishes the anticancer efficacy of CDDP by repairing DNA strands. Olaparib (OLA), a PARP inhibitor, enhances the accumulation of DNA damage by inhibiting its repair. Therefore, the combination of these two drugs enhances the sensitivity of CDDP chemotherapy, leading to improved th… Show more

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