2022
DOI: 10.1101/2022.10.03.22280675
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Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing

Abstract: Genomic profiling of hematologic malignancies has augmented our understanding of variants that contribute to disease pathogenesis and supported development of prognostic models that inform disease management in the clinic. Tumor only sequencing assays are limited in their ability to identify definitive somatic variants, which can lead to ambiguity in clinical reporting and patient management. Here, we describe the MSK-IMPACT Heme cohort, a comprehensive data set of somatic alterations from paired tumor and no… Show more

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