Enhanced Clinical Utility of ??-CDT in a General Population

Sillanaukee, Pekka; Massot, Nuria; Jousilahti, Pekka; Vartiainen, Erkki; Poikolainen, Kari; Olsson, Ulf; Alho, Hannu

doi:10.1097/00000374-200008000-00010

Cited by 6 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A significant association with age, body mass index, and smoking was observed for the three markers. The results presented here for γ-CDT, together with its values of sensitivity and specificity among the general population (23), suggest the usefulness of this new combined marker in clinical practice.…”

Section: Discussionsupporting

confidence: 51%

Dose Response of Laboratory Markers to Alcohol Consumption in a General Population

Sillanaukee¹,

Massot²,

Jousilahti³

et al. 2000

American Journal of Epidemiology

View full text Add to dashboard Cite

The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), γ-glutamyltransferase (GGT), and their combination (γ-CDT) was studied in an age-and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT. Age was positively associated with GGT and γ-CDT. In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, γ-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately. Am J Epidemiol 2000;152:747-51.

show abstract

Section: Discussionsupporting

confidence: 51%

Dose Response of Laboratory Markers to Alcohol Consumption in a General Population

Sillanaukee¹,

Massot²,

Jousilahti³

et al. 2000

American Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…(3) As usual, in general practice, our sample consisted of a high percentage of women (56.0%). This is higher than in most other studies, e.g., Chen et al (2003) 33.2%, Hermansson et al (2000) 37.0%, and Sillanaukee et al (2000b) 42.9%. Some studies excluded women altogether (Meerkerk et al, 1999;Mikkelsen et al, 1998;Mundle et al, 1999b).…”

Section: Discussioncontrasting

confidence: 65%

“…(2) In most previous studies, there are exclusions of patients with liver disease (Anton et al, 2002;Chen et al, 2003;Harasymiw et al, 2004;Mundle et al, 2000;Reynaud et al, 2000), patients on medications that affect the hepatic system (Mundle et al, 1999b(Mundle et al, , 2000Myrick et al, 2001;Sillanaukee et al, 2000aSillanaukee et al, , 2000b, or patients who are pregnant (Anton et al, 2002;Reynaud et al, 2000;Sillanaukee et al, 2000aSillanaukee et al, , 2000b. Although the potential impairment of the enzyme system is a logical reason for exclusion, those studies with exclusions cannot claim either a representative sample or a more realistic estimation of the practical use of the markers.…”

Section: Discussionmentioning

confidence: 99%

DOVER and QUVER—New Marker Combinations to Detect and Monitor At‐risk Drinking

Berner

Bentele

Kriston

et al. 2006

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Our study is to date the largest practice-based trial that examines the value of the markers CDT and gamma-GT and their combinations for the screening of at-risk drinking in general practice under routine conditions. Our ROC analysis clearly demonstrated that the combination of the markers gamma-GT and %CDT under routine conditions with a behaviorally oriented reference standard leads to an improvement of diagnostic performance, more so than the use of single markers.

show abstract

“…The average amount of pure alcohol (g/day) was calculated as follows: pure alcohol (g) at any one time x frequency of alcohol use (1/day). Alcohol consumption was categorized as abstainers/light drinkers (< 15 g of pure alcohol/day), moderate drinkers (15–40 g/day), and heavy drinkers (> 40 g/day) [26]. …”

Section: Methodsmentioning

confidence: 99%

The association between physical fitness and depressive symptoms among young adults: results of the Northern Finland 1966 birth cohort study

et al. 2013

View full text Add to dashboard Cite

BackgroundThe effect of physical activity on mental health has been the subject of research for several decades. However, there is a lack of studies investigating the association between physical fitness, including both cardiorespiratory and muscular fitness and depressive symptoms among general population. The aim of this study was to determine the association between physical fitness and depressive symptoms among young adults.MethodsThe study population consists of 5497 males and females, members of the Northern Finland birth cohort of 1966, who at age 31 completed fitness tests and filled in a questionnaire including questions about depressive symptoms (Hopkins’ Symptom Checklist-25) and physical activity. Cardiorespiratory fitness was measured by a 4-min step test and muscular fitness by tests of maximal isometric handgrip and isometric trunk extension. The odds ratios (OR) with 95% confidence intervals (95% CI) for having depressive symptoms were calculated for quintiles groups of physical fitness using the third, median quintile as reference group, and the results were adjusted for potential confounding variables.ResultsDepressive symptoms were most common among males and females in the lowest quintile group of trunk extension test (OR 1.58 and 95% CI 1.07-2.32 in males and OR 1.43 and 95% CI 1.03-2.0 in females) and among males in the lowest quintile group of handgrip strength (OR 1.64 95% CI 1.11-2.42) compared to the reference group. Level of self-reported physical activity was inversely associated with depressive symptoms both in males (OR 1.74 95% CI 1.25-2.36) and females (OR 1.36 95% CI 1.05-1.75). The cardiorespiratory fitness was not associated with depressive symptoms (OR 1.01 95% CI 0.68-1.49 in males and 0.82 95% CI 0.57-1.16 in females).ConclusionsThe results indicate that low level of isometric endurance capacity of trunk extensor muscles is associated with high level of depressive symptoms in both sexes. In males, also poor handgrip strength is associated with increased levels of depressive symptoms. The physical activity level is inversely associated with the prevalence of depressive symptoms among young adults.

show abstract

Enhanced Clinical Utility of ??-CDT in a General Population

Abstract: Compared with single markers, a significant improvement of sensitivity was obtained when the combination of both markers was used, especially in females.

Cited by 6 publications

References 25 publications

Dose Response of Laboratory Markers to Alcohol Consumption in a General Population

Dose Response of Laboratory Markers to Alcohol Consumption in a General Population

DOVER and QUVER—New Marker Combinations to Detect and Monitor At‐risk Drinking

The association between physical fitness and depressive symptoms among young adults: results of the Northern Finland 1966 birth cohort study

Contact Info

Product

Resources

About