Enhanced corrosion resistance and bonding strength of Mg substituted β-tricalcium phosphate/Mg(OH)2 composite coating on magnesium alloys via one-step hydrothermal method

Lin, Yishu; Cai, Shu; Song, Jian; Xie, Dongli; Ling, Rui; Sun, Jia; Wei, Jieling; Shen, Kaier; Xu, Guohua

doi:10.1016/j.jmbbm.2018.11.007

Cited by 30 publications

(15 citation statements)

References 45 publications

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“…Lower porosity and better continuity of the films improved the corrosion resistance of the films. Alkaline pretreatment of Mg alloy substrates has also shown to enhance corrosion resistance and bonding strength of the deposited bioapatite [96]. The parameters of this technique can be easily manipulated in order to finely tune the oxide layer.…”

Section: Discussionmentioning

confidence: 99%

Surface Activation and Pretreatments for Biocompatible Metals and Alloys Used in Biomedical Applications

Huynh

Ngo

Golden

2019

International Journal of Biomaterials

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To improve the biocompatibility of medical implants, a chemical composition of bone-like material (e.g., hydroxyapatite) can be deposited on the surface of various substrates. When hydroxyapatite is deposited on surfaces of orthopedic implants, several parameters must be addressed including the need of rapid bone ingrowth, high mechanical stability, corrosion resistance, biocompatibility, and osseointegration induction. However, the deposition process can fail due to poor adhesion of the hydroxyapatite coating to the metallic substrate. Increasing adhesion by enhancing chemical bonding and minimizing biocoating degradation can be achieved through surface activation and pretreatment techniques. Surface activation can increase the adhesion of the biocoating to implants, providing protection in the biological environment and restricting the leaching of metal ions in vivo. This review covers the main surface activation and pretreatment techniques for substrates such as titanium and its alloys, stainless steel, magnesium alloys, and CoCrMo alloys. Alkaline, acidic, and anodizing techniques and their effects on bioapatite deposition are discussed for each of the substrates. Other chemical treatment and combination techniques are covered when used for certain materials. For titanium, the surface pretreatments improve the thickness of the TiO2 passive layer, improving adhesion and bonding of the hydroxyapatite coating. To reduce corrosion and wear rates on the surface of stainless steel, different surface modifications enhance the bonding between the bioapatite coatings and the substrate. The use of surface modifications also improves the morphology of hydroxyapatite coatings on magnesium surfaces and limits the concentration of magnesium ions released into the body. Surface treatment of CoCrMo alloys also decreased the concentration of harmful ions released in vivo. The literature covered in this review is for pretreated surfaces which then undergo deposition of hydroxyapatite using electrodeposition or other wet deposition techniques and mainly limited to the years 2000-2019.

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Section: Discussionmentioning

confidence: 99%

Surface Activation and Pretreatments for Biocompatible Metals and Alloys Used in Biomedical Applications

Huynh

Ngo

Golden

2019

International Journal of Biomaterials

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“…In order to slow down the corrosion rate of magnesium alloy (Mg20Zn), Ca-P coating was deposited from the solution containing Ca(NO 3 ) 2 and NaH 2 PO 4 . The PO 4 3− ions present in the solution react with calcium ions according to Reaction (7).…”

Section: Discussionmentioning

confidence: 99%

“…Different types of protective coatings were deposited on magnesium substrates. The most popular coatings are hydroxides-based coatings [ 6 , 7 ], metal oxide based coatings [ 8 , 9 ], silane sol-gel coatings [ 10 , 11 , 12 ], Ca-P coatings [ 13 , 14 , 15 ] and polymer coatings [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Corrosion Resistance of MgZn Alloy Covered by Chitosan-Based Coatings

Kozina

Krawiec

Starowicz

et al. 2021

IJMS

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Chitosan coatings are deposited on the surface of Mg20Zn magnesium alloy by means of the spin coating technique. Their structure was investigated using Fourier Transform Infrared Spectroscopy (FTIR) an X-ray photoelectron spectroscopy (XPS). The surface morphology of the magnesium alloy substrate and chitosan coatings was determined using Scanning Electron Microscope (FE-SEM) analysis. Corrosion tests (linear sweep voltamperometry and chronoamperometry) were performed on uncoated and coated magnesium alloy in the Hank’s solution. In both cases, the hydrogen evolution method was used to calculate the corrosion rate after 7-days immersion in the Hank’s solution at 37 °C. It was found that the corrosion rate is 3.2 mm/year and 1.2 mm/year for uncoated and coated substrates, respectively. High corrosion resistance of Mg20Zn alloy covered by multilayer coating (CaP coating + chitosan water glass) is caused by formation of CaSiO3 and Ca3(PO4)2 compounds on its surface.

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“…The combination of SA and Gel improves the performance and quality of scaffolds, merging the advantages of the two natural polymers for tissue engineering applications. 14,15 To effectively promote bone healing, inorganic materials, such as nano-hydroxyapatite (nHA) 16 or tricalcium phosphate, 17 are often added to biological scaffolds. Hydroxyapatite (HA) is the major inorganic component in human bones and teeth and has good bone conduction and induction characteristics, 18 which is conducive to the final direct combination with bones.…”

Section: Introductionmentioning

confidence: 99%

Study on 3D-Printed Emodin/Nano-Hydroxyapatite Scaffolds Promoting Bone Regeneration by Supporting Osteoblast Proliferation and Macrophage M2 Polarization

Pan

Chen

Meng

et al. 2023

ACS Appl. Polym. Mater.

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The treatment of bone defects caused by diseases, trauma, or tumor has always been a great clinical challenge. Implantation of bone biomaterials into bone defect areas is an effective method for bone injury repair. In this study, we used three-dimensional (3D) printing technology to prepare nano-hydroxyapatite (nHA)/sodium alginate (SA)/gelatin (Gel) hydrogel scaffolds loaded with different ratios (0, 0.13, 0.26, 0.39, 0.53, and 0.79‰) of emodin (EM) (EM/nHA/SA/Gel). Scanning electron microscopy showed that the scaffolds had a smooth surface without fracture and nHA was evenly distributed on the surface. The cell proliferation and migration results showed that the 0.39‰ EM group, in particular, could significantly promote the proliferation and migration of mouse embryonic osteoblast precursor (MC3T3-E1) cells and significantly increase the mRNA expression of osteogenic differentiation-related genes (bone morphogenetic protein/BMP-2, BMP-9, osteocalcin). In addition, the 0.39‰ EM group exhibited the best effect on osteogenic differentiation-related proteins (alkaline phosphatase, Runx 2, OSX). The expression of M2 polarization-related genes (arginase-1, CD206) also significantly increased after the treatment with the 0.39‰ EM group. Micro-CT showed that in the rat skull defect model, the EM/nHA/SA/Gel scaffold group significantly promoted bone regeneration after being implanted into the skull for 30 days. Our results indicate that the EM/nHA/SA/Gel hydrogel scaffolds can not only directly promote the proliferation and differentiation of osteoblasts but also indirectly promote osteogenic differentiation by supporting M2 polarization of macrophages. EM/nHA/SA/Gel hydrogel scaffolds are potential bone tissue engineering materials for bone regeneration.

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Enhanced corrosion resistance and bonding strength of Mg substituted β-tricalcium phosphate/Mg(OH)2 composite coating on magnesium alloys via one-step hydrothermal method

Cited by 30 publications

References 45 publications

Surface Activation and Pretreatments for Biocompatible Metals and Alloys Used in Biomedical Applications

Surface Activation and Pretreatments for Biocompatible Metals and Alloys Used in Biomedical Applications

Corrosion Resistance of MgZn Alloy Covered by Chitosan-Based Coatings

Study on 3D-Printed Emodin/Nano-Hydroxyapatite Scaffolds Promoting Bone Regeneration by Supporting Osteoblast Proliferation and Macrophage M2 Polarization

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