Enhanced corrosion resistance and reduced cytotoxicity of the <scp>AZ91</scp> Mg alloy by plasma nitriding and a hierarchical structure composed of ciprofloxacin‐loaded polymeric multilayers and calcium phosphate coating

Shanaghi, Ali; Mehrjou, Babak; Chu, Paul K.

doi:10.1002/jbm.a.37258

Cited by 6 publications

(6 citation statements)

References 43 publications

(214 reference statements)

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“…Ma et al and Shanaghi et al suggest that nitridation of coatings on Mg and Al alloys has a positive influence on their corrosion resistance. 33,36 Thus, we attribute the slightly reduced corrosion resistance of Mg-B and Al-B alloys to their physical characteristics.…”

Section: ■ Results and Discussionmentioning

confidence: 93%

“…These results suggest that the addition of nitrogen-containing compounds to the bath chemistry improved the degree of crystallinity of magnesium oxide in the coating. We hypothesize that the arc energies generated during aminophenol-enhanced PEO treatment of AZ80 alloys are sufficiently high for the formation of Mg 3 N 2 in the coating chemistry . The appearance of magnesium oxynitride in the coating chemistry could suggest that the localized arc energies are capable of nitriding MgO.…”

Section: Resultsmentioning

confidence: 99%

“…We hypothesize that the arc energies generated during aminophenol-enhanced PEO treatment of AZ80 alloys are sufficiently high for the formation of Mg 3 N 2 in the coating chemistry. 33 The appearance of magnesium oxynitride in the coating chemistry could suggest that the localized arc energies are capable of nitriding MgO.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Protecting Light Metal Alloys Using a Sustainable Plasma Electrolytic Oxidation Process

Hou¹,

Gorthy²,

Mardon³

et al. 2022

ACS Omega

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Low-density metals such as Mg and Al (and their alloys) are of high interest for lightweight engineering applications in various industries. Moisture sensitivity, poor tribology, and corrosion susceptibility limit the direct application of these light metals. Plasma electrolytic oxidation (PEO) is extensively used to passivate light metals against corrosion and enhance their mechanical properties. PEO processes in current use are often energy-intensive and use toxic electrolytes. Incorporating composite characteristics to PEO-treated surfaces typically requires modification of electrolytes with nanoparticle addition. Some applications also need post-treatment of oxidized coatings to ensure functionality. We report a versatile, environmentally friendly PEO process that uses organo-silicate electrolytes enriched with nitrogen-containing solutions. The single-step process produces ∼6 μm thick, uniform, adherent, and porous oxide coatings on AZ80 and Al6061 surfaces in 15 min. We evaluated the influence and effectiveness of in situ nitridation by comparing the coating properties with those on alloys treated in PEO electrolytes without nitrogen-containing chemicals. The two sets of coatings were porous with multilayered basalt-like topographies and were composed of metal oxides and metal silicates. Alloys treated in nitrogen-containing electrolytes exhibited the presence of oxynitrides. The use of nitrogencontaining PEO electrolytes resulted in coatings with enhanced mechanical behavior. We found that the corrosion resistance of coatings prepared using low voltages in this study was comparable to the traditional PEO-treated coatings reported in the literature. Nitridation of the coatings, however, appears to have a slightly negative influence on the coatings' corrosion resistance. Our future work will focus on improving the corrosion resistance of the mechanically resilient, nitride-containing PEO-treated coatings.

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Section: ■ Results and Discussionmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

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Protecting Light Metal Alloys Using a Sustainable Plasma Electrolytic Oxidation Process

Hou¹,

Gorthy²,

Mardon³

et al. 2022

ACS Omega

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“…Polyelectrolytes have recently attracted attention by inciting Ca–P conversion coatings on Mg alloys as they facilitate heterogeneous nucleation of Ca–P precipitates with uniform coating deposition. Shanaghi et al [ 134 ] reported that the Ca–P layer deposited on PAA-coated AZ91 Mg alloy significantly improves the osseointegration response. Using a special heat treatment, yang et al [ 135 ] developed a defect-free SiO 2 /PAA coating that acts as a template for mineralizing Ca–P layers on AZ31 Mg alloy.…”

Section: Coatings and Their Current Statusmentioning

confidence: 99%

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Singh

Batra

Kumar

et al. 2023

Bioactive Materials

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“…28,29 Many studies have been focused on the layer-by-layer deposition of AZ91 Mg alloy with polymer coating for orthopedic applications. [30][31][32][33][34] However, only a few studies have been focused on the layer-by-layer technique deposition on AZ91 Mg alloy and its systematic physicochemical and biological characterization for cardiovascular stent applications.…”

mentioning

confidence: 99%

Biodegradable AZ91 magnesium alloy/sirolimus/poly D, L‐lactic‐co‐glycolic acid‐based substrate for cardiovascular device application

Mohanta,

Ramdhun,

Thirugnanam

et al. 2023

J Biomed Mater Res

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Biodegradable drug‐eluting stents (DESs) are gaining importance owing to their attractive features, such as complete drug release to the target site. Magnesium (Mg) alloys are promising materials for future biodegradable DESs. However, there are few explorations using biodegradable Mg for cardiovascular stent application. In this present study, sirolimus‐loaded poly D, L‐lactic‐co‐glycolic acid (PLGA)‐coated/ sirolimus‐fixed/AZ91 Mg alloy‐based substrate was developed via a layer‐by‐layer approach for cardiovascular stent application. The AZ91 Mg alloy was prepared through the squeeze casting technique. The casted AZ91 Mg alloy (Mg) was alkali‐treated to provide macroporous networks to hold the sirolimus and PLGA layers. The systematic characterization was investigated via electrochemical, optical, physicochemical, and in‐vitro biological characteristics. The presence of the Mg17Al12 phase in the Mg sample was found in the x‐ray diffraction system (XRD) spectrum which influences the corrosion behavior of the developed substrate. The alkali treatment increases the substrate's hydrophilicity which was confirmed through static contact angle measurement. The anti‐corrosion characteristic of casted‐AZ91 Mg alloy (Mg) was slightly less than the sirolimus‐loaded PLGA‐coated alkali‐treated AZ91 Mg alloy (Mg/Na/S/P) substrate. However, dissolution rates for both substrates were found to be controlled at cell culture conditions. Radiographic densities of AZ91 Mg alloy substrates (Mg, Mg/Na, and Mg/Na/S/P) were measured to be 0.795 ± 0.015, 0.742 ± 0.01, and 0.712 ± 0.017, respectively. The star‐shaped structure of 12% sirolimus/PLGA ensures the bioavailability of the drugs. Sirolimus release kinetic was fitted up to 80% with the “Higuchi model” for Mg samples, whereas Mg/Na/S/P showed 45% fitting with a zero‐order mechanism. The Mg/Na/S/P substrate showed a 70% antithrombotic effect compared to control. Further, alkali treatment enhances the antibacterial characteristic of AZ91 Mg alloy. Also, the alkali‐treated sirolimus‐loaded substrates (Mg/Na/S and Mg/Na/S/P) inhibit the valvular interstitial cell's growth significantly in in‐vitro. Hence, the results imply that sirolimus‐loaded PLGA‐coated AZ91 Mg alloy‐based substrate can be a potential candidate for cardiovascular stent application.

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Enhanced corrosion resistance and reduced cytotoxicity of the AZ91 Mg alloy by plasma nitriding and a hierarchical structure composed of ciprofloxacin‐loaded polymeric multilayers and calcium phosphate coating

Cited by 6 publications

References 43 publications

Protecting Light Metal Alloys Using a Sustainable Plasma Electrolytic Oxidation Process

Protecting Light Metal Alloys Using a Sustainable Plasma Electrolytic Oxidation Process

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Biodegradable AZ91 magnesium alloy/sirolimus/poly D, L‐lactic‐co‐glycolic acid‐based substrate for cardiovascular device application

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