Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials

Su, Yingchao; Wang, Kai; Gao, Julia; Yang, Yong; Qin, Yi‐Xian; Zheng, Yufeng; Zhu, Donghui

doi:10.1016/j.actbio.2019.03.055

Cited by 180 publications

(135 citation statements)

References 79 publications

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“…To achieve the biocompatibility and biofunctions on the implant materials, surface biofunctionalization is one of the easiest ways to change the surface properties which can improve the surface bioactivity, eliminate or control the degradation rate, and prevent implant-related infections, etc. [ [16] , [17] , [18] , [19] ]. For example, surface modification with appropriate coatings can create a favorable surface morphology for the adsorption of proteins in the interactions with biological fluids, and thus promote the cell–extracellular matrix (ECM) interactions and the production of growth factors [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Compared to other treatment technologies, surface modifications and functionalizations provide a possibility to modify the surface properties of biomaterials to be suitable for specific biomedical applications [ 19 , 20 , 22 ]. As the main inorganic component in bone tissue [ 23 ], calcium phosphate (CaP) possesses inherent biocompatibility when applied as biomaterials in human body [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Biofunctionalization of metallic implants by calcium phosphate coatings

Cockerill

Zheng

et al. 2019

Bioactive Materials

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184

105

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Metallic materials have been extensively applied in clinical practice due to their unique mechanical properties and durability. Recent years have witnessed broad interests and advances on surface functionalization of metallic implants for high-performance biofunctions. Calcium phosphates (CaPs) are the major inorganic component of bone tissues, and thus owning inherent biocompatibility and osseointegration properties. As such, they have been widely used in clinical orthopedics and dentistry. The new emergence of surface functionalization on metallic implants with CaP coatings shows promise for a combination of mechanical properties from metals and various biofunctions from CaPs. This review provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings. We first glance over different types of CaPs with their coating methods and in vitro and in vivo performances, and then give insight into the representative biofunctions, i.e. osteointegration, corrosion resistance and biodegradation control, and antibacterial property, provided by CaP coatings for metallic implant materials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biofunctionalization of metallic implants by calcium phosphate coatings

Cockerill

Zheng

et al. 2019

Bioactive Materials

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184

105

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“…However, the peripheral bone immune microenvironment interference with the surface properties of Ti implant is considered an important factor affecting implantation success rates. Due to their specific biological effects, metal ions phosphates have received widespread attention in the field of surface modification of metallic medical materials [ 10 , [31] , [32] , [33] ]. For example, Sr can improve early bone formation of the phosphate coating on the Ti implant surface, while its specific role and mechanism in osteoimmunomodulation requires further research.…”

Section: Discussionmentioning

confidence: 99%

“…The phosphate chemical conversion (PCC) technique is a chemical and electrochemical process of forming PCC coatings and firmly binds to the substrate. The PCC coating synthesized directly on the Ti implant surface can not only regulate wear- and corrosion-resistance, adhesion, roughness, and hydrophilicity, but also couples elements such as calcium (Ca), zinc (Zn), stronium (Sr) into the coating [ [9] , [10] , [11] , [12] ]. As the main component of human bone, Ca is used in synthesis and application of various biomaterials [ 8 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Zhao

Zuo

Wang

et al. 2021

Materials Science and Engineering: C

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Titanium (Ti) and its alloys are believed to be promising scaffold materials for dental and orthopedic implantation due to their ideal mechanical properties and biocompatibility. However, the host immune response always causes implant failures in the clinic. Surface modification of the Ti scaffold is an important factor in this process and has been widely studied to regulate the host immune response and to further promote bone regeneration. In this study, a calcium-strontium-zinc-phosphate (CSZP) coating was fabricated on a Ti implant surface by phosphate chemical conversion (PCC) technique, which modified the surface topography and element constituents. Here, we envisioned an accurate immunomodulation strategy via delivery of interleukin (IL)-4 to promote CSZP-mediated bone regeneration. IL-4 (0 and 40 ng/mL) was used to regulate immune response of macrophages. The mechanical properties, biocompatibility, osteogenesis, and anti-inflammatory properties were evaluated. The results showed that the CSZP coating exhibited a significant enhancement in surface roughness and hydrophilicity, but no obvious changes in proliferation or apoptosis of bone marrow mesenchymal stem cells (BMMSCs) and macrophages. In vitro, the mRNA and protein expression of osteogenic related factors in BMMSCs cultured on a CSZP coating, such as ALP and OCN, were significantly higher than those on bare Ti. In vivo, there was no enhanced bone formation but increased macrophage type 1 (M1) polarization on the CSZP coating. IL-4 could induce M2 polarization and promote osteogenesis of BMMSCs on CSZP in vivo and in vitro. In conclusion, the CSZP coating is an effective scaffold for BMMSCs osteogenesis, and IL-4 presents the additional advantage of modulating the immune response for bone regeneration on the CSZP coating in vivo.

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“…However, it is found that Zn clusters were studied recently, where the reports show stable Zn clusters having different stacking arrangement of the atoms as well as interesting electronic properties [25][26][27][28][29][30]. On the other hand, there is an increasing interest in different Znbased nanoparticles, the same for biomaterials, as well as in solid state physics, and other technological applications [31][32][33][34][35][36]. Therein, it has been showed that by using controlled conditions several Zn-based nanocrystals, passivated or dopped, can be grown in the symmetric zinc-blende phase [37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Total energy calculation for the metallic hcp phase of Zn in the bulk, layered, and quantum dot limits

Olguı́n¹

2020

Condens. Matter Phys.

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The structural and electronic properties of the metallic hcp phase of Zn in the bulk, monolayer, bilayer, and quantum dot limits have been studied by using total energy calculations. From our calculated density of states and electronic band structure, in agreement with previous work, bulk hybridization of the Zn-4s, 3p, and 3d orbitals is obtained. Furthermore, we found that this orbital hybridization is also obtained for the monolayer, bilayer, and quantum dot systems. At the same time, we found that the Zn monolayer and bilayer systems show electronic properties characteristic of lamellar systems, while the quantum dot system shows the behavior predicted for a 0D system.

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Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials

Cited by 180 publications

References 79 publications

Biofunctionalization of metallic implants by calcium phosphate coatings

Biofunctionalization of metallic implants by calcium phosphate coatings

Interleukin-4 assisted calcium-strontium-zinc-phosphate coating induces controllable macrophage polarization and promotes osseointegration on titanium implant

Total energy calculation for the metallic hcp phase of Zn in the bulk, layered, and quantum dot limits

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