Enhanced depth imaging optical coherence tomography of the choroid in migraine patients: implications for the association of migraine and glaucoma

Dadacı, Zeynep; Doganay, Fatma; Acır, Nurşen Öncel; Aydin, Hacer Doganay; Borazan, Mehmet

doi:10.1136/bjophthalmol-2013-304711

Cited by 29 publications

(25 citation statements)

References 25 publications

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“…23 In contrast, a different study, similar to our results, reported a decrease in the choroidal thickness in migraine patients, especially five of the patients during attack, according to the control group, which supports our suggestion of decreased blood flow according to the vasogenic theory of migraine. 18 It is also reported that the patients with migraine often suffer from vascular dysregulation involving the choroid 24 and this may be in relation with the choroidal thickness changes in migraine patients.…”

Section: Discussionsupporting

confidence: 91%

Choroid thickness and ocular pulse amplitude in migraine during attack

Dervişoğulları

Totan

Gençler

2014

Eye

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Aim To compare the choroidal thickness and ocular pulse amplitude (OPA) measurements obtained during the attack period in migraine patients and age and gender matched control group participants using high definition optical coherence tomography (OCT). Methods Thirty eyes at the side of the headache of 30 subjects with a diagnosis of migraine with or without aura and unilateral migraine and 29 age and gender matched healthy participants were enrolled in this observational, cross-sectional study. OCT scans were performed to all participants. Choroidal thicknesses were measured at the fovea, 1500 mm nasal and 1500 mm temporal to the fovea. Intraocular pressure (IOP) and OPA were also measured. Results The choroidal thickness measurements obtained during the attack period in migraine patients were (mean ± SD) 279.82 ± 35.87, 250.05 ± 29.49, and 239.58 ± 27.92 and in control group were 308.20 ± 44.97, 276.95±41.39, and 281.60±41.38 at foveal, nasal, and temporal measurement points, respectively. Choroidal thickness significantly decreased according to the control group (Po0.05) at all measured points in migraine patients during attack. IOP (mean ± SD) values were 16.71 ± 3.26 and17.40 ± 3.19 and OPA (mean ± SD) values were 2.26 ± 0.81 and 2.64 ± 1.03 in migraine and control groups, respectively, and did not seem to be changed (P40.05). Conclusions Choroidal thickness was found to be significantly decreased in unilateral migraine patients during the attack period when compared with the control group, whereas OPA did not change. The possible implications of these findings on the association between migraine and glaucoma are discussed.

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Section: Discussionsupporting

confidence: 91%

Choroid thickness and ocular pulse amplitude in migraine during attack

Dervişoğulları

Totan

Gençler

2014

Eye

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“…They conclude that the increased choroidal thickness of the migraine patients might be due to rebound vasodilatation in the acute attack period. In parallel with these results, Dadaci et al [2] reported choroidal thickening during the attack period in the eyes on the headache side of patients with bilateral or unilateral migraine compared to basal levels. They discussed that presumed neurogenic inflammation can occur in choroid and may result in increased choroidal thickness during a headache attack.…”

Section: Discussionmentioning

confidence: 54%

“…Migraine patients usually have concomitant periorbital pain, photophobia or other visual symptoms [2]. Because ophthalmologists frequently encounter these patients, a detailed ophthalmological examination could provide valuable information about pathogenesis of migraine.…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickness measurements in migraine patients during attack-free period

et al. 2015

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To identify any structural differences in macular choroidal thickness in migraine patients and compare them with that of control subjects by using spectral domain optic coherence tomography (SD-OCT). In this prospective study, choroidal thicknesses of 32 migraine patients during migraine attack-free period and 32 age- and sex-matched healthy subjects were measured using SD-OCT. All patients underwent a complete ophthalmic examination before the measurements. The migraine patients were classified into the migraine with aura group or the migraine without aura group. Migraine severity was assessed by visual analog scale (VAS), migraine disability questionnaire (Migraine Disability Assessment Score (MIDAS), and Wong-Baker faces pain rating scale. Thirty eyes of 32 subjects (31 female and 1 male) in the migraine group and 32 eyes of 32 subjects (31 female and 1 male) in control group were evaluated. In the study group, 16 patients suffered migraine without aura (MWA) and 16 patients were diagnosed as migraine with aura (MA). The mean subfoveal choroidal thickness (SFCT) was 353.3 ± 66.5 μm in the control group versus 304.3 ± 72.9 μm and 276.1 ± 61.4 μm in MWA and MA groups, respectively. The difference in SFCT between the migraine patients and the controls was significant (p < 0.001). Additionally, a moderate correlation was found between SFCT and the VAS score and W baker score (r = 0.48, p = 0.008 and r = 0.43, p = 0.02, respectively). The choroidal thickness was found to decrease significantly not only in migraine patients with aura but also in those without aura during the attack-free period.

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“…A cross-sectional study imaged migraine participants during a migraine attack and reported an increase in choroidal thickness relative to a group of non-headache controls (Karalezli et al, 2014). Dadaci et al (2014) shed further light on this result, by comparing choroidal thickness across two test visits in the same migraine observers (one at baseline, the other during an attack). Choroidal thickness was increased during a migraine attack compared to the baseline interictal visit (Dadaci et al, 2014).…”

Section: Choroidal Imaging In People With Migrainementioning

confidence: 94%

Clinical impact of migraine for the management of glaucoma patients

Nguyen

Lek

Vingrys

et al. 2016

Progress in Retinal and Eye Research

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Migraine is a common and debilitating primary headache disorder that affects 10-15% of the general population, particularly people of working age. Migraine is relevant to providers of clinical eye-care because migraine attacks are associated with a range of visual sensory symptoms, and because of growing evidence that the results of standard tests of visual function necessary for the diagnosis and monitoring of glaucoma (visual fields, electrophysiology, ocular imaging) can be abnormal due to migraine. These abnormalities are measureable in-between migraine events (the interictal period), despite patients being asymptomatic and otherwise healthy. This picture is further complicated by epidemiological data that suggests an increased prevalence of migraine in patients with glaucoma, particularly in patients with normal tension glaucoma. We discuss how migraine, as a co-morbidity, can confound the results and interpretation of clinical tests that form part of contemporary glaucoma evaluation, and provide practical evidence-based recommendations for the clinical testing and management of patients with migraine who attend eye-care settings.

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Enhanced depth imaging optical coherence tomography of the choroid in migraine patients: implications for the association of migraine and glaucoma

Abstract: Choroidal thickness was found to be significantly increased in migraine patients during the attack period when compared to basal levels. The possible implications of this finding on the association between migraine and glaucoma are discussed.

Cited by 29 publications

References 25 publications

Choroid thickness and ocular pulse amplitude in migraine during attack

Choroid thickness and ocular pulse amplitude in migraine during attack

Choroidal thickness measurements in migraine patients during attack-free period

Clinical impact of migraine for the management of glaucoma patients

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