Enhanced digestive enzyme activity and anti-adipogenic of fermented soy-powder milk with probiotic Lactobacillus plantarum P1201 through an increase in conjugated linoleic acid and isoflavone aglycone content

Hwang, Chung Eun; Lee, Dong Hoon; Kim, Baolo; Joo, Ok Soo; Kim, Su Cheol; Lee, Jin Hwan; Hong, Su Young; Choi, Ae‐Jin; Cho, Kye Man

doi:10.11002/kjfp.2018.25.4.461

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…The anti-obesity effect of FSPM can be attributed to conjugated linoleic acid (CLA) and isoflavone aglycones, which downregulated lipoprotein lipase (LPL), adiponectin, adipocyte fatty acid-binding protein (aP2), fatty acid synthase (FAS), and acetyl CoA carboxylase (ACC) mRNA. Additionally, FSPM increased the anti-obesity activity and pancreatic enzymes' inhibitory function [168]. These findings suggest that the fermented hydrolysate milks may have helped to increase the value of the soybean [168].…”

Section: Small Molecule Natural Productsmentioning

confidence: 78%

“…Additionally, FSPM increased the anti-obesity activity and pancreatic enzymes' inhibitory function [168]. These findings suggest that the fermented hydrolysate milks may have helped to increase the value of the soybean [168]. Hwang et al [169] also revealed that in soy-powder yogurts (SPYs) made using Lactobacillus brevis and L. plantarum, the total average isoflavones decreased while there was an increase in aglycones.…”

Section: Small Molecule Natural Productsmentioning

confidence: 93%

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Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review

Babajide Rowaiye,

Emenyonu,

Nwonu

et al. 2024

Academia Biology

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The hallmarks of type 2 diabetes (T2D) include peripheral insulin resistance and insulin insufficiency. Given the significance of T2D as a major public health concern, the goal of this review article is to highlight the role of bioactive properties of soybeans in the prevention, control, and management of the disease. This study examined how bioactive molecules from soybeans modulate key enzymes that affect T2D. A systematic search of electronic databases such as PubMed and Google Scholar was conducted to find relevant original studies or non-original peer-reviewed papers published on the subject. Keyword combinations such as "Soy OR soybeans", "Soybeans AND anti-inflammatory", "Soybeans AND anti-oxidative", and "Soybeans AND antidiabetic" were used in the search. A search was also conducted on all the key enzymes and bioactive molecules mentioned in the review. A total of 194 articles published in English were selected. Both in vivo and in vitro experiments, and human clinical trials have proven a marked efficacy of these bioactive molecules in suppressing the key enzyme biomarkers that modulate T2D pathogenesis. Based on empirical research, the consumption of soybean products and ingredients is associated with a lower incidence of T2D. These findings will contribute to the present understanding of the therapeutic potential of soy-derived compounds. However, this study does not capture the individual variances to these biomolecules; hence, there is the need for more future pharmacokinetic studies to better understand potential interactions, safety, and more efficacy concerns.

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Section: Small Molecule Natural Productsmentioning

confidence: 78%

Section: Small Molecule Natural Productsmentioning

confidence: 93%

Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review

Babajide Rowaiye,

Emenyonu,

Nwonu

et al. 2024

Academia Biology

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“…Soymilk with 2% sucrose was hydrolyzed with 10 U of cellulase, protease, and esterase at 37 °C for 24 h, and finally 1.0% safflower oil and the starter (2.0×10 7 CFU/mL) were added. Fermentation was carried out at 35 °C for 48 h. L. plantarum P1201 increased the content of isoflavones in the aglycone form (daidzein, glycitein and genistein) and produced CLA in fermented soymilk by improving some functional properties that positively influenced adipogenesis and lipid metabolism [118].…”

Section: Cla-producing L Plantarum Strains In Fermented Foodmentioning

confidence: 99%

Production of Conjugated Linoleic Acid (CLA) by <em>Lactiplantibacillus plantarum</em>: A Review With Emphasis on Fermented Foods

Iorizzo,

Di Martino,

Letizia

et al. 2024

Preprint

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The term Conjugated Linoleic Acid (CLA) refers generically to a class of positional and geometric conjugated dienoic isomers of linoleic acid. Among the isomers of linoleic acid cis9, trans11-CLA (c9, t11-CLA) and trans10, cis12-CLA (t10, c12-CLA) are found to be bio-logically active isomers, and they occur naturally in milk, dairy products and meat from ruminants. In addition, some vegetables and some sea-foods have also been reported to contain CLA. Although the CLA levels in these natural sources are insufficient to confer the essential health benefits, anti-carcinogenic or anti-cancer effects are of current interest. In the rumen, CLA is an intermediate of isomerization and the biohydrogenation process of linoleic acid to stearic acid conducted by ruminal microorganisms. In addition to rumen bacteria, some other bacteria, such as Propionibacterium, Bifidobacterium and some lactic acid bacteria (LAB) are also capable of producing CLA. In this regard, Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) has demon-strated the ability to produce CLA isomers from linoleic acid by multiple enzymatic activi-ties, including hydration, dehydration, and isomerization. L. plantarum is one of the most versatile species of LAB and the bacterium is widely used in the food industry as a micro-bial food culture. The studies reviewed in this article reveal how, in the production of some fermented foods, the use of appropriate strains of L. plantarum, as a starter or additional culture, can be considered a critical factor in the design of new CLA-enriched functional foods.

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LC‐MS/MS and GC‐MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus Hausskn. & Velen. extracts

Fayez,

Fahmy,

Zengin

et al. 2023

Archiv der Pharmazie

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The chemical composition as well as antioxidant, antiproliferative, and enzyme inhibition activities of extracts from aerial parts of Thymus leucostomus H ausskn. & V elen. obtained with hexane, methanol, and water were evaluated. Results showed that the methanol extract had significantly (p < 0.05) the highest total phenolic content (TPC; 107.80 mg GAE/g) and total flavonoids content (TFC; 25.21 mg RE/g) followed by the aqueous extract (102.72 mg GAE/g and 20.88 mg RE/g, respectively). LC‐MS/MS‐guided profiling of the three extracts revealed that rosmarinic acid (34.8%), hesperetin (42.9%), and linoleic acid (18%) were the dominant compounds in the methanol, aqueous and hexane extracts, respectively. GC‐MS analysis of the hexane extract showed that ɣ‐sitosterol (29.9%) was the major constituent. The methanol extract displayed significantly (p < 0.05) the highest Cu++, Fe+++, and Mo(VI) ions scavenging and reducing properties while the aqueous extract exerted significantly (p < 0.05) the highest metal chelating power (42.51 mg EDTAE/g). Both the hexane and methanol extracts effectively inhibited the acetylcholinesterase enzyme (2.63 and 2.65 mg GALAE/g, respectively) while the former extract exerted significantly (p < 0.05) the highest butyrylcholinesterase (2.32 mg GALAE/g), tyrosinase (19.73 mg KAE/g), and amylase (1.16 mmol ACAE/g) inhibition capacity. The aqueous extract exhibited the best glucosidase inhibition property (0.49 mmol ACAE/g). The methanol and hexane extracts exerted a higher cytotoxic effect on HT‐29 (IC50: 8.12 µg/mL) and HeLa (IC50 = 8.08 µg/mL) cells, respectively. In conclusion, these results provide valuable insight into the potential use of T. leucostomus bioactive extracts in different pharmaceutical applications.

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Enhanced digestive enzyme activity and anti-adipogenic of fermented soy-powder milk with probiotic Lactobacillus plantarum P1201 through an increase in conjugated linoleic acid and isoflavone aglycone content

Cited by 9 publications

References 37 publications

Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review

Bioactive molecules from soybeans (Glycine max) with anti-type 2 diabetes activity: a systematic review

Production of Conjugated Linoleic Acid (CLA) by <em>Lactiplantibacillus plantarum</em>: A Review With Emphasis on Fermented Foods

LC‐MS/MS and GC‐MS profiling, antioxidant, enzyme inhibition, and antiproliferative activities of Thymus leucostomus Hausskn. & Velen. extracts

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