Enhanced dissolution characteristics of piroxicam–Soluplus® nanosuspensions

Patnaik, Sandeep; Chunduri, L. A. Avinash; Akilesh, M. Sai; Bhagavatham, Sai Krishna Srimadh; Venkataramaniah, K.

doi:10.1080/17458080.2016.1178402

Cited by 18 publications

(13 citation statements)

References 23 publications

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“…The presence of Soluplus® in a drug containing matrix has been shown to cause the Gibbs free energies of transfer, to become more negative. 67 This correlates with the drug solubilisation to become more spontaneous in the presence of the polymer . This is ascribed to presence of hydroxyl (–OH) on the polymer which confer Soluplus® with surface active properties which promote drug dissolution via micellar solubilisation.…”

Section: Resultsmentioning

confidence: 95%

“…The fast dissolution profile exhibited by all four CLC-loaded MAP formulations may be attributed to the hydrophilic nature of the needles, given the high aqueous solubility of CLC (45 mg mL −1 ) 66 as well as the presence of Soluplus® along the needle length and its solubilising effect when exposed to dermal interstitial fluid. 67…”

Section: Resultsmentioning

confidence: 99%

“…This is ascribed to presence of hydroxyl (-OH) on the polymer which confer Soluplus® with surface active properties which promote drug dissolution via micellar solubilisation. 67 Regarding drug delivery systems for gout, several researchers have explored the utility of the transdermal route for the administration of anti-inflammatory agents. For instance, Zhang et al 75 developed ethosomes, which are lipid nanocarriers composed of a relatively high concentration of ethanol, for delivering CLC transdermally across the skin.…”

Section: Biomaterials Science Papermentioning

confidence: 99%

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Soluplus®-based dissolving microarray patches loaded with colchicine: towards a minimally invasive treatment and management of gout

et al. 2022

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Biomaterials Science Papermentioning

confidence: 99%

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Soluplus®-based dissolving microarray patches loaded with colchicine: towards a minimally invasive treatment and management of gout

et al. 2022

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“…10 mM solution of piroxicam in DMSO was prepared and then diluted with MEM to obtain the appropriate concentration. MTT assay was used to evaluate the cytotoxicity of piroxicam and polysaccharide derivatives in the NIH3T3 line [ 47 , 48 ]. 8 × 10 4 fibroblasts were seeded in each well of the 96-well plate and 100 µL of MEM containing the polymer was added.…”

Section: Methodsmentioning

confidence: 99%

Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam

Lachowicz

Kaczyńska

Bodzoń‐Kułakowska

et al. 2020

IJMS

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Low water solubility frequently compromises the therapeutic efficacy of drugs and other biologically active molecules. Here, we report on coacervate polysaccharide nanoparticles (CPNs) that can transport and release a model hydrophobic drug, piroxicam, to the cells in response to changes in temperature. The proposed, temperature-responsive drug delivery system is based on ionic derivatives of natural polysaccharides—curdlan and hydroxypropyl cellulose. Curdlan was modified with trimethylammonium groups, while the anionic derivative of hydroxypropyl cellulose was obtained by the introduction of styrenesulfonate groups. Thermally responsive nanoparticles of spherical shape and average hydrodynamic diameter in the range of 250–300 nm were spontaneously formed in water from the obtained ionic polysaccharides as a result of the coacervation process. Their morphology was visualized using SEM and AFM. The size and the surface charge of the obtained objects could be tailored by adjusting the polycation/polyanion ratio. Piroxicam (PIX) was effectively entrapped inside the nanoparticles. The release profile of the drug from the CPNs-PIX was found to be temperature-dependent in the range relevant for biomedical applications.

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“…The cytotoxic activity of piroxicam in NIH3T3 line was estimated by the MTT assay [42,43]. 7 × 10 4 fibroblasts were cultured in 100 µL volume of DMEM medium in 96-well plates in the presence of various concentrations of polymers (C-PUL, PUL, DEX, DEX-A), as well as in the presence of piroxicam dissolved in DMSO.…”

Section: Biological Studiesmentioning

confidence: 99%

Nanohydrogels Based on Self-Assembly of Cationic Pullulan and Anionic Dextran Derivatives for Efficient Delivery of Piroxicam

et al. 2019

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A cationic derivative of pullulan was obtained by grafting reaction and used together with dextran sulfate to form polysaccharide-based nanohydrogel cross-linked via electrostatic interactions between polyions. Due to the polycation-polyanion interactions nanohydrogel particles were formed instantly and spontaneously in water. The nanoparticles were colloidally stable and their size and surface charge could be controlled by the polycation/polyanion ratio. The morphology of the obtained particles was visualized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The resulting structures were spherical, with hydrodynamic diameters in the range of 100-150 nm. The binding constant (K a ) of a model drug, piroxicam, to the cationic pullulan (C-PUL) was determined by spectrophotometric measurements. The value of K a was calculated according to the Benesi-Hildebrand equation to be (3.6 ± 0.2) × 10 3 M −1 . After binding to cationic pullulan, piroxicam was effectively entrapped inside the nanohydrogel particles and released in a controlled way. The obtained system was efficiently taken up by cells and was shown to be biocompatible.Pharmaceutics 2019, 11, 622 2 of 16 bioactive compound (e.g., low molecular weight drugs, proteins, DNA or RNA) and release it in a controlled way [5][6][7][8]. In order to adjust the release profile of a bioactive substance to the needs of the therapy the ability of nanogels to respond to the microenvironmental stimuli such as light, magnetic field, changes in ionic strength, pH, temperature, or redox potential, are often exploited [9][10][11][12][13]. For example, sodium alginate was combined with N-isopropylacrylamide to obtain a dual-responsive system for oxytetracycline delivery, where the drug release could be effectively controlled by both pH and temperature [14]. Chitosan based nanogel which showed pH-dependent drug release which mimicked the skin cancer micro-environment was very recently proposed by Sahu et al. [15].It is, however, worth noticing, that many of the studied nanogel systems are based on the combination of polysaccharide and synthetic polymer, which often makes them less biocompatible. Other large group of nanogels is made by the hydrophobic modifications of polysaccharides. For these polymers the formation of the stable nanogel usually requires additional steps (solvent removal, heating, ionotrpic gelation, cross-linking).Pullulan is a natural polysaccharide produced from starch by the fungus Aureobasidium pullulans. This water-soluble polymer has a linear structure consisting of repeating maltotriose units [16]. Due to its ordered structure pullulan has film-forming ability, considerable mechanical strengths and adhesiveness, thus it is widely used as a component of composite polymer materials, in the construction of electrospun fibres and gels [16][17][18]. The latter are usually obtained by chemical cross-linking [19], a highly universal method which allows to obtain hydrogels and nanohydrogels with high mec...

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Enhanced dissolution characteristics of piroxicam–Soluplus® nanosuspensions

Cited by 18 publications

References 23 publications

Soluplus®-based dissolving microarray patches loaded with colchicine: towards a minimally invasive treatment and management of gout

Soluplus®-based dissolving microarray patches loaded with colchicine: towards a minimally invasive treatment and management of gout

Coacervate Thermoresponsive Polysaccharide Nanoparticles as Delivery System for Piroxicam

Nanohydrogels Based on Self-Assembly of Cationic Pullulan and Anionic Dextran Derivatives for Efficient Delivery of Piroxicam

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