“…Among alcoholics, one small post-mortem study reported that higher impulsivity was associated with increased 5HT2A receptor binding (Thompson et al, 2012). In animal models, alcohol exposure has been associated with region-specific increases (Akash et al, 2008) and decreases (George et al, 2010) in 5HT2A receptors binding. Studies indicate that increased activity in 5HT2A-mediated pathways relative to 5HT2C activity increases cue response and impulsivity in rat models of cocaine addiction (Cunningham and Anastasio, 2014).…”