Enhanced Drug Delivery of Antibiotic-Loaded Acrylic Bone Cements Using Calcium Phosphate Spheres

Qin, Tao; López, Alejandro; Öhman, Caroline; Engqvist, Håkan; Persson, Cecilia; Xia, Wei

doi:10.5301/jabfm.5000222

Cited by 10 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to optimaize the release rate of antibiotic, incorporate strontium doped calcium phosphate spheres (SCPS) was incorporated into PMMA cement. Incorporating SCPS into PMMA was found to enhance the antibiotic release and deliver strontium ions to the surrounding which can improve bone regeneration (25).…”

Section: Modification Of Bone Cementmentioning

confidence: 99%

“…As natural bone material, calcium phosphate particles are regarded very promising in many biomedical fields (10,(21)(22)(23)(24). Calcium phosphate micro spheres have been successfully applied as delivery carrier bone cement (25) and as tooth remineralization agent in toothpast and bleaching paste (26). Moreover, advanced applications to protect vaccine could be a new hot topic.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The concentration of calcium phosphate spheres on micro hardness of dentin

2018

Adv.App.Mater.

View full text Add to dashboard Cite

show abstract

Section: Modification Of Bone Cementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The concentration of calcium phosphate spheres on micro hardness of dentin

2018

Adv.App.Mater.

View full text Add to dashboard Cite

show abstract

“…To strengthen its interaction with the matrix, studies are devoted to the modification of HA surface. Modification is mainly carried out by the following three types: coupling agent, esterification reaction, and grafting modification of polymer . In our earlier study, Minyu Rao et al .…”

Section: Introductionmentioning

confidence: 99%

Biological activity of hydroxyapatite/poly(methylmethacrylate) bone cement with different surface morphologies and modifications for induced osteogenesis

Che

Min

Rao

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

Although having advantages such as good mechanical property and rapid curing, the poor absorption and biological activity of hydroxyapatite (HA)/poly(methylmethacrylate) (PMMA) bone cement limits its clinical application. Therefore, it is of vital importance to improve the integration and the biological activity of HA/PMMA bone cement. In this study, spherical and rod-like HA/PMMA bone cement with different content of P(MMA-co-MPS) were chosen to enhance its interface bioactivity. The content of P(MMA-co-MPS) on the surface of HA was 12, 30, 15, and 28%, respectively, corresponding to 0.3 r-HA, 1.5 r-HA, 0.3 s-HA, and 1.5 s-HA, whose calcium-to-phosphorus (Ca/P) ratios were 1.62, 1.5, 1.65, and 1.53, respectively, and were confirmed by energy dispersive spectroscopy. From scanning electron microscope, we found that the spherical HA (s-HA) promotes the biomineralization on the surface of PMMA than rod-like HA (r-HA). In addition, cell experiments in vitro showed that s-HA/PMMA with lower modification degree (0.3) of P(MMA-co-MPS) results in more cell adhesion and more evenly distributed on surface spreading while observed under laser confocal microscope. Meanwhile, in vitro, cell proliferation and alkaline phosphatase activity indicated that s-HA/PMMA bone cement promotes early osteogenic differentiation of rBMSCs in a deeper extent than r-HA/PMMA, demonstrating that 0.3 s-HA/PMMA provides a favorable theoretical basis for the further clinical application of HA/PMMA bone cement as an optimized bone repair material.

show abstract

“…Thus, calcium phosphate cement (CPC), which has been proved to be a biodegradable antibiotic carrier, has been widely used as filling material in bone defects in osteomyelitis [ 3 – 5 ]. It fills the space left by debridement, releases their loaded antibiotics during degradation, and leaves no medium and substratum for bacterial colonization [ 6 , 7 ]. However, it was reported that the duration of antibiotics release of CPC was less than 1 month in vitro [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Low-Frequency Pulsed Ultrasound on Drug Delivery, Antibacterial Efficacy, and Bone Cement Degradation in Vancomycin-Loaded Calcium Phosphate Cement

et al. 2018

View full text Add to dashboard Cite

BackgroundCalcium phosphate cement (CPC) has been applied as a biodegradable antibiotic carrier in osteomyelitis. However, the drug delivery, antibacterial efficacy, and degradation rate of CPC are insufficient and require further improvement in clinical application.Material/MethodsVancomycin-loaded CPC columns were prepared, and eluted in simulated body fluid. The drug delivery was assessed in the ultrasound group and control group by fluorescence polarization immunoassay. The antibacterial efficacy of vancomycin in the ultrasound group and control groups was investigated by standard plate count method. Low-frequency pulsed ultrasound (46.5 kHz, 900 mW/cm2) was used to produce a sinusoidal wave in the ultrasound groups. The percentage of residual weight was evaluated to assess the degradation of CPC.ResultsThe concentration and cumulatively released percentage of vancomycin in the ultrasound group were higher than that in the control group at each time point (p<0.05). The duration of vancomycin concentration over the level of minimum inhibitory concentration was significantly prolonged in the ultrasound group (p<0.05). Antibacterial efficacy of vancomycin in the ultrasound group was significantly greater than that in the control group with same concentration of vancomycin (p<0.05). The percentage of residual weight in the ultrasound group was significantly less than that in the control group (p<0.05).ConclusionsLow-frequency pulsed ultrasound can enhance vancomycin release, prolong the duration of vancomycin concentration at high levels, and accelerate the degradation rate of vancomycin-loaded CPC.

show abstract

Enhanced Drug Delivery of Antibiotic-Loaded Acrylic Bone Cements Using Calcium Phosphate Spheres

Abstract: Our results showed that SCPS/PMMA antibiotic-loaded cement had enhanced antibiotic release, delivered strontium ions and maintained mechanical properties, indicating that the SCPS additive could be a good alternative for controlling the drug-delivery properties of PMMA cement.

Cited by 10 publications

References 25 publications

The concentration of calcium phosphate spheres on micro hardness of dentin

The concentration of calcium phosphate spheres on micro hardness of dentin

Biological activity of hydroxyapatite/poly(methylmethacrylate) bone cement with different surface morphologies and modifications for induced osteogenesis

Effect of Low-Frequency Pulsed Ultrasound on Drug Delivery, Antibacterial Efficacy, and Bone Cement Degradation in Vancomycin-Loaded Calcium Phosphate Cement

Contact Info

Product

Resources

About