Enhanced drug metabolism and renal dysfunction.

Németh, Ilona; T, Szeleczki

doi:10.1111/j.1365-2125.1981.tb01109.x

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…The latter results in an increased volume of distribution, and an increased plasma elimination half-life (Bennet et al 1977;Dettli 1976;Gibson 1980;Keller et al 1984;Neureth & Szelezhi 1981;Reidenberg 1977). Depending on the elimination characteristics of the substance, decreased plasma protein binding may result in increased free plasma concentrations and, therefore, possibly in enhanced pharmacological effects (Gibson 1980).…”

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confidence: 97%

Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing

Harten¹,

Burggraaf²,

Brummelen³

et al. 1989

Clinical Pharmacokinetics

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The pharmacokinetics and cardiovascular effects of the calcium entry blocker nisoldipine (10 mg twice daily) were studied in 6 patients with renal failure (creatinine clearance 23 +/- 9 ml/min) and 6 healthy control subjects after a single dose and 1 week of oral administration. No significant differences in elimination half-life, area under the concentration/time curve, peak plasma drug concentration and time to reach that peak were observed between renal patients and control subjects, and between single-dose and short term administration. The decrease in systolic blood pressure and increase in heart rate were similar in both groups, but the decrease in diastolic blood pressure was more pronounced in the patients. This can be explained by increased haemodynamic sensitivity for nisoldipine. Adverse effects were mainly restricted to the first day of administration.

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