Enhanced Efficacy of Nilvadipine in Hypertensives Whose Raised Ambulatory Blood Pressure Is Sustained During Sleep

Yoshikawa, Hiroyuki; Ohta, Akihiro; Kasamatsu, Ken; Ueno, Chieko; Funai, Hisako; Kuse, Seiji; Satani, Osamu; Nakamura, Nobuo; Fukuda, Kazuya; Hano, Takuzo; Ueno, Yoshio; Nishio, Ichiro; Iseki, Yoshio

doi:10.1016/s0895-7061(97)00406-8

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…There are many studies about the nocturnal dipping effects of antihypertensives such as amlodipine, verapamil, doxazocin, nilvadipine, and barnidipine. [7][8][9][10][11][12][13][14] In those studies, the effects of antihypertensives on nocturnal dipping ranged from 0.7 mm Hg to 12 mm Hg. In the present study, nocturnal dipping increased by 4.98 -7.34 mm Hg (5.21 -10.19 mm Hg to 10.20 -7.56 mm Hg, pretreatment to post-treatment) after acupuncture treatment, indicating its potential to improve the circadian rhythm of BP in patients with hypertension.…”

Section: Discussionmentioning

confidence: 98%

“…4 Thus, the antihypertensive agents that have been shown to affect nocturnal BP dipping have recently started to be emphasized. [7][8][9][10][11][12][13][14] Acupuncture, which has been used for centuries and is thought to be potentially helpful for lowering BP, has been explored both in Western and Eastern literature. [15][16][17] Recently, several randomized controlled trials have been conducted on the effects of acupuncture on hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Can Acupuncture Affect the Circadian Rhythm of Blood Pressure? A Randomized, Double-Blind, Controlled Trial

Kim

Cho²,

Park³

et al. 2012

The Journal of Alternative and Complementary Medicine

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Objectives: The objective of the study was to investigate the effect of acupuncture on the circadian rhythm of blood pressure (BP) in patients with hypertension. Design: The study was designed as a randomized, double-blind, controlled trial. Subjects were randomly divided into an active acupuncture group and a sham acupuncture group. Each patient received real or sham acupuncture treatment twice a week for 8 weeks. Acupuncture needles were inserted at bilateral ST 36 plus PC 6; placebo points. Subjects: Thirty-three (33) patients with essential hypertension were the subjects. Outcome measures: Twenty-four (24)-hour ambulatory BP was assessed before and after treatment. Results: After the treatment period, there was a significant increase in nocturnal diastolic BP dipping compared to that at baseline (10.20 -7.56 mm Hg versus 5.21 -10.19 mm Hg, p = 0.038) in the active acupuncture group but not in the sham acupuncture group. The nocturnal diastolic BP dipping response to active acupuncture treatment was significantly different from the response seen with the sham acupuncture treatment ( p = 0.041). The number of dippers also increased from 4 to 8 in the active acupuncture group. Average systolic and diastolic BP was not changed significantly except for nighttime diastolic BP (90.32 -11.47 mm Hg to 87.83 -9.16 mm Hg, p = 0.041). Conclusions: It is suggested that acupuncture treatment could be useful for improving the circadian rhythm of BP in patients with hypertension.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Can Acupuncture Affect the Circadian Rhythm of Blood Pressure? A Randomized, Double-Blind, Controlled Trial

Kim

Cho²,

Park³

et al. 2012

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

show abstract

Changes of Nocturnal Blood Pressure Dipping Status in Hypertensives by Nighttime Dosing of α-Adrenergic Blocker, Doxazosin

2000

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Abstract-Abnormal nocturnal blood pressure (BP) dipping status may be partly determined by nocturnal sympathetic activity. We studied the effect of nighttime dosing of an ␣ 1 -adrenergic blocker, doxazosin, on the BP dipping status of 118 hypertensives, all of whom underwent 24-hour ambulatory BP monitoring before and after treatment. The mean nighttime/daytime ratio of systolic BP was increased (0.91 after therapy versus 0.89 at baseline, PϽ0.05). The patients were initially divided into 4 groups on the basis of their dipping status at the baseline assessment: 18 (15%) were extreme dippers, with a nighttime systolic BP fall of at least 20% of daytime BP; 46 (39%) were dippers (fall between 10% and 20%); 48 (41%) were nondippers (fall between 0% and 10%); and 6 (5%) were risers (nocturnal increase of systolic BP). A shift in dipping status toward less nocturnal BP dipping was observed after doxazosin therapy (PϽ0.05). Dipping status was determined by nighttime more than by daytime BP, and this was not explained by differences in the number of daytime and nighttime readings. The effects of doxazosin on the mean nocturnal systolic BP changes were an increase of 4.3 mm Hg in extreme dippers and decreases of 0.7 mm Hg in dippers, 12 mm Hg in nondippers, and 18 mm Hg in risers; the reduction was only significant in the latter 2 groups (both PϽ0.01). To estimate the effects of regression to the mean on the changes in dipping status, we also defined dipping status with the average of the BPs before and after doxazosin and found no difference in the degree of nighttime BP reduction among each group. The reduction of daytime BP was now significantly greater in the subgroups with less dipping: 6.4 mm Hg for extreme dippers and 16 mm Hg for risers (PϽ0.05). In conclusion, nighttime dosing with doxazosin markedly affects the nocturnal BP dipping status of hypertensives, but the apparently greater reduction in nighttime pressure in nondippers and risers may be, at least partly, due to the effect of regression to the mean. The most important determinants of the effect of doxazosin were the absolute BP levels, both day and night, rather than dipping status per se. (Hypertension. 2000;35:787-794.) Key word: blood pressure monitoring Ⅲ adrenergic receptor blocking Ⅲ circadian rhythm Ⅲ prospective studies

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Enhanced Efficacy of Nilvadipine in Hypertensives Whose Raised Ambulatory Blood Pressure Is Sustained During Sleep

Cited by 2 publications

References 7 publications

Can Acupuncture Affect the Circadian Rhythm of Blood Pressure? A Randomized, Double-Blind, Controlled Trial

Can Acupuncture Affect the Circadian Rhythm of Blood Pressure? A Randomized, Double-Blind, Controlled Trial

Changes of Nocturnal Blood Pressure Dipping Status in Hypertensives by Nighttime Dosing of α-Adrenergic Blocker, Doxazosin

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