Enhanced efficacy of propranolol therapy for infantile hemangiomas based on a mesoporous silica nanoplatform through mediating autophagy dysfunction

Wu, Haiwei; Wang, Xuan; Liang, Hao; Zheng, Jiawei; Huang, Shengyun; Zhang, Dongsheng

doi:10.1016/j.actbio.2020.02.033

Cited by 17 publications

(10 citation statements)

References 58 publications

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“…Due to the important application of mesoporous materials in drugs and gene carriers, the toxicity of mesoporous materials cannot be ignored. Some studies have found that mesoporous silica shows high cytotoxicity in vivo and in vitro during the study of infantile hemangioma, which can induce the excessive accumulation of autophagosomes by increasing the formation of autophagosomes and inhibiting autophagy degradation 17 . Some studies have also found that in different liver cancer cell lines, nanomaterials have high cytotoxicity, which can increase the amount of soluble FOLR1 secreted by tumor cells 18,19 .…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have found that mesoporous silica shows high cytotoxicity in vivo and in vitro during the study of infantile hemangioma, which can induce the excessive accumulation of autophagosomes by increasing the formation of autophagosomes and inhibiting autophagy degradation. 17 Some studies have also found that in different liver cancer cell lines, nanomaterials have high cytotoxicity, which can increase the amount of soluble FOLR1 secreted by tumor cells. 18,19 The increase of the size or density of hollow mesoporous silica will increase its cytotoxicity, which can cause nuclear fragmentation and irreversible cell damage.…”

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confidence: 99%

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Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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Mesoporous silica is widely used because of its unique and excellent properties, especially it can be used as a drug carrier and gene carrier in the biomedical field. After the mesoporous silica is put into clinical use, it is more likely to be exposed in human body. Therefore, the effect of mesoporous silica on human body cannot be ignored. The injury of vascular endothelial cells is a prerequisite for the occurrence of many cardiovascular diseases. As a drug and gene carrier, mesoporous silica increases its contact with vascular endothelial cells, so its toxic effect on cardiovascular system cannot be ignored. In this study, amino (NH2) and carboxyl (COOH) were modified on mesoporous silica SBA‐15 by post‐grafting. The results showed that it still maintained the one‐dimensional hexagonal mesoporous structure of SBA‐15 and had typical mesoporous structure. Then human umbilical vein endothelial cells (HUVECs) were infected with SBA‐15, NH2‐SBA‐15, and COOH‐SBA‐15. The results showed that the functionalized mesoporous silica SBA‐15 had cytotoxicity to HUVECs and damaged the cell membrane, but compared with the unmodified mesoporous silica SBA‐15 the cytotoxicity of functionalized mesoporous silica SBA‐15 was lower and the toxicity of carboxyl modified group was the lowest. By comparing the cell inhibition rate and the expression level of lactate dehydrogenate and reactive oxygen species induced by the three materials, oxidative damage and cell membrane damage may be two mechanisms of cytotoxicity. Mesoporous silica SBA‐15 has an effect on cardiovascular system by inducing the high expression of nitric oxide, intercellular adhesive molecule‐1 and vascular cell adhesive molecule‐1 in HUVECs. In summary, our results show that mesoporous silica is toxic to vascular endothelial cells.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Zhao

Zhang

et al. 2021

Environmental Toxicology

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“…Nanotechnology applied in the field of drug therapy helped design nanostructures that enhance drug administration efficiency. Mesoporous silica nanoparticles (MSNs) have an important role in cancer therapy and, Propranolol loading into MSNs, seem to have a cumulative effect of apoptosis of hemangioma stem cells and cell proliferation suppression [61]. The mechanism found at the base of this phenomenon is autophagy induced by synchronous release of Propranolol and nanoparticles from the MSNs and autophagosome accumulation caused by autophagy induction combined with autophagy blockade.…”

Section: β-Blocker Therapymentioning

confidence: 99%

“…Another mechanism consists of reactive oxygen species (ROS) generation by the Propranolol-MSNs coupling with subsequent apoptotic effects. What makes MSNs an attractive way for Propranolol delivery is the fact that this technology allows usage of lower β-blocker doses and ensures a targeted drug delivery [61].…”

Section: β-Blocker Therapymentioning

confidence: 99%

Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

Luca¹,

Miron²,

Trandafir³

et al. 2021

Rom J Morphol Embryol

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Infantile hemangiomas (IHs) are the most frequent pediatric benign vascular tumors, with a reported incidence of 5% to 10%. They have self-limiting evolution pattern divided into a growth phase in the first 12 months and a regression one, that may take up to 10 years. Occasionally, hemangiomas might lead to local or systemic complications, depending on their morphological characteristics. The first line of treatment is β-blockers, such as Propranolol, Timolol, Nadolol, administered either locally or systemically. Newer therapeutic strategies involving laser therapy and angiotensin-converting enzyme inhibitors are being studied, while older treatment modalities like corticosteroids, Imiquimod, Vincristine, Bleomycin and Interferon-α have become second line therapy options. Before establishing the appropriate treatment, clinical, histological, and imaging investigations are required.

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“…The size of SiO 2 nanoparticles is generally between 250–400 nm [ 7 ]. It is a very good drug delivery system, especially as a nanocarrier for drugs, gene delivery, and bioimaging and photodynamic therapy [ 8 , 9 , 10 ]. However, SiO 2 nanoparticles still have shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chitosan Derivatives Modified Mesoporous Silica Nanoparticles as Delivery Carrier

Wang

et al. 2021

Molecules

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Chitosan is a non-toxic biological material, but chitosan is insoluble in water, which hinders the development and utilization of chitosan. Chitosan derivatives N-2-Hydroxypropyl trimethyl ammonium chloride (N-2-HACC) and carboxymethyl chitosan (CMCS) with good water solubility were synthesized by our laboratory. In this study, we synthesized mesoporous SiO2 nanoparticles by the emulsion, and then the mesoporous SiO2 nanoparticles were modified with γ-aminopropyltriethoxysilane to synthesize aminated mesoporous SiO2 nanoparticles; CMCS and N-2-HACC was used to cross-link the aminated mesoporous SiO2 nanoparticles to construct SiO2@CMCS-N-2-HACC nanoparticles. Because the aminated mesoporous SiO2 nanoparticles with positively charged can react with the mucous membranes, the virus enters the body mainly through mucous membranes, so Newcastle disease virus (NDV) was selected as the model drug to evaluate the performance of the SiO2@CMCS-N-2-HACC nanoparticles. We prepared the SiO2@CMCS-N-2-HACC nanoparticles loaded with inactivated NDV (NDV/SiO2@CMCS-N-2-HACC). The SiO2@CMCS-N-2-HACC nanoparticles as delivery carrier had high loading capacity, low cytotoxicity, good acid resistance and bile resistance and enteric solubility, and the structure of NDV protein encapsulated in the nano vaccine was not destroyed. In addition, the SiO2@CMCS-N-2-HACC nanoparticles could sustain slowly released NDV. Therefore, the SiO2@CMCS-N-2-HACC nanoparticles have the potential to be served as delivery vehicle for vaccine and/or drug.

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Enhanced efficacy of propranolol therapy for infantile hemangiomas based on a mesoporous silica nanoplatform through mediating autophagy dysfunction

Cited by 17 publications

References 58 publications

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells

Morphological, genetic and clinical correlations in infantile hemangiomas and their mimics

Evaluation of Chitosan Derivatives Modified Mesoporous Silica Nanoparticles as Delivery Carrier

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